Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.007 0.129 -9999.0 0.0 -0.564 4.0 4.0 IHH -0.055 0.196 -9999.0 0.0 -0.561 18.0 18.0 SHH Np/Cholesterol/GAS1 -0.122 0.193 -9999.0 0.0 -0.389 44.0 44.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.121 0.192 0.386 44.0 -9999.0 0.0 44.0 SMO/beta Arrestin2 0.002 0.096 -9999.0 0.0 -0.453 1.0 1.0 SMO -0.004 0.101 -9999.0 0.0 -0.481 1.0 1.0 AKT1 0.016 0.052 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.007 0.052 -9999.0 0.0 -0.61 1.0 1.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.004 0.1 -9999.0 0.0 -0.474 1.0 1.0 STIL -0.102 0.207 -9999.0 0.0 -0.541 15.0 15.0 DHH N/PTCH2 -0.009 0.063 -9999.0 0.0 -0.438 3.0 3.0 DHH N/PTCH1 -0.0 0.105 -9999.0 0.0 -0.392 1.0 1.0 PIK3CA 0.007 0.05 -9999.0 0.0 -0.584 1.0 1.0 DHH -0.002 0.089 -9999.0 0.0 -0.602 3.0 3.0 PTHLH 0.005 0.161 -9999.0 0.0 -0.781 4.0 4.0 determination of left/right symmetry -0.004 0.1 -9999.0 0.0 -0.474 1.0 1.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.005 0.16 -9999.0 0.0 -0.772 4.0 4.0 IHH N/Hhip -0.054 0.175 -9999.0 0.0 -0.41 25.0 25.0 DHH N/Hhip -0.038 0.124 -9999.0 0.0 -0.443 12.0 12.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.1 -9999.0 0.0 -0.474 1.0 1.0 pancreas development -0.028 0.152 -9999.0 0.0 -0.609 9.0 9.0 HHAT -0.006 0.104 -9999.0 0.0 -0.61 4.0 4.0 PI3K -0.003 0.036 -9999.0 0.0 -0.423 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.046 0.18 -9999.0 0.0 -0.61 13.0 13.0 somite specification -0.004 0.1 -9999.0 0.0 -0.474 1.0 1.0 SHH Np/Cholesterol/PTCH1 -0.074 0.178 -9999.0 0.0 -0.528 8.0 8.0 SHH Np/Cholesterol/PTCH2 -0.091 0.16 -9999.0 0.0 -0.353 36.0 36.0 SHH Np/Cholesterol/Megalin -0.141 0.204 -9999.0 0.0 -0.388 51.0 51.0 SHH -0.103 0.214 -9999.0 0.0 -0.459 36.0 36.0 catabolic process 0.001 0.108 -9999.0 0.0 -0.446 1.0 1.0 SMO/Vitamin D3 -0.061 0.174 -9999.0 0.0 -0.577 5.0 5.0 SHH Np/Cholesterol/Hhip -0.112 0.191 -9999.0 0.0 -0.394 40.0 40.0 LRP2 -0.081 0.221 -9999.0 0.0 -0.608 21.0 21.0 receptor-mediated endocytosis -0.126 0.176 -9999.0 0.0 -0.565 11.0 11.0 SHH Np/Cholesterol/BOC -0.093 0.165 -9999.0 0.0 -0.363 36.0 36.0 SHH Np/Cholesterol/CDO -0.1 0.168 -9999.0 0.0 -0.359 39.0 39.0 mesenchymal cell differentiation 0.111 0.19 0.391 40.0 -9999.0 0.0 40.0 mol:Vitamin D3 -0.072 0.179 -9999.0 0.0 -0.527 8.0 8.0 IHH N/PTCH2 -0.023 0.119 -9999.0 0.0 -0.33 18.0 18.0 CDON -0.006 0.1 -9999.0 0.0 -0.591 4.0 4.0 IHH N/PTCH1 0.001 0.109 -9999.0 0.0 -0.451 1.0 1.0 Megalin/LRPAP1 -0.066 0.158 -9999.0 0.0 -0.443 21.0 21.0 PTCH2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.093 0.163 -9999.0 0.0 -0.361 36.0 36.0 PTCH1 0.001 0.108 -9999.0 0.0 -0.447 1.0 1.0 HHIP -0.028 0.153 -9999.0 0.0 -0.61 9.0 9.0