Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.015 0.096 -9999.0 0.0 -0.547 3.0 3.0 IHH 0.004 0.099 -9999.0 0.0 -0.245 16.0 16.0 SHH Np/Cholesterol/GAS1 -0.04 0.112 -9999.0 0.0 -0.262 25.0 25.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.111 0.261 25.0 -9999.0 0.0 25.0 SMO/beta Arrestin2 0.029 0.076 -9999.0 0.0 -0.352 1.0 1.0 SMO 0.008 0.063 -9999.0 0.0 -0.367 1.0 1.0 AKT1 0.014 0.067 -9999.0 0.0 -0.351 1.0 1.0 ARRB2 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.041 -9999.0 0.0 -0.457 1.0 1.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.009 0.063 -9999.0 0.0 -0.362 1.0 1.0 STIL -0.023 0.118 0.259 3.0 -0.35 4.0 7.0 DHH N/PTCH2 0.034 0.047 -9999.0 0.0 -0.272 3.0 3.0 DHH N/PTCH1 0.019 0.07 -9999.0 0.0 -0.267 3.0 3.0 PIK3CA 0.023 0.023 -9999.0 0.0 -0.233 1.0 1.0 DHH 0.019 0.061 -9999.0 0.0 -0.383 3.0 3.0 PTHLH 0.009 0.129 -9999.0 0.0 -0.779 3.0 3.0 determination of left/right symmetry 0.009 0.063 -9999.0 0.0 -0.362 1.0 1.0 PIK3R1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.009 0.128 -9999.0 0.0 -0.77 3.0 3.0 IHH N/Hhip 0.003 0.117 -9999.0 0.0 -0.416 8.0 8.0 DHH N/Hhip 0.012 0.096 -9999.0 0.0 -0.314 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.009 0.063 -9999.0 0.0 -0.362 1.0 1.0 pancreas development -0.0 0.112 -9999.0 0.0 -0.457 8.0 8.0 HHAT 0.02 0.058 -9999.0 0.0 -0.457 2.0 2.0 PI3K 0.032 0.023 -9999.0 0.0 -0.158 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.005 0.119 -9999.0 0.0 -0.457 9.0 9.0 somite specification 0.009 0.063 -9999.0 0.0 -0.362 1.0 1.0 SHH Np/Cholesterol/PTCH1 -0.025 0.096 -9999.0 0.0 -0.333 3.0 3.0 SHH Np/Cholesterol/PTCH2 -0.026 0.097 -9999.0 0.0 -0.256 18.0 18.0 SHH Np/Cholesterol/Megalin -0.061 0.133 -9999.0 0.0 -0.288 31.0 31.0 SHH -0.045 0.121 0.233 1.0 -0.333 18.0 19.0 catabolic process 0.012 0.061 -9999.0 0.0 -0.292 4.0 4.0 SMO/Vitamin D3 -0.012 0.104 0.335 2.0 -0.483 1.0 3.0 SHH Np/Cholesterol/Hhip -0.037 0.117 -9999.0 0.0 -0.287 21.0 21.0 LRP2 -0.04 0.163 -9999.0 0.0 -0.435 20.0 20.0 receptor-mediated endocytosis -0.049 0.125 -9999.0 0.0 -0.447 6.0 6.0 SHH Np/Cholesterol/BOC -0.026 0.098 -9999.0 0.0 -0.261 18.0 18.0 SHH Np/Cholesterol/CDO -0.028 0.097 -9999.0 0.0 -0.255 18.0 18.0 mesenchymal cell differentiation 0.037 0.116 0.286 21.0 -9999.0 0.0 21.0 mol:Vitamin D3 -0.007 0.117 0.325 2.0 -0.368 2.0 4.0 IHH N/PTCH2 0.024 0.063 -9999.0 0.0 -0.26 2.0 2.0 CDON 0.017 0.055 -9999.0 0.0 -0.289 4.0 4.0 IHH N/PTCH1 0.035 0.064 -9999.0 0.0 -0.294 4.0 4.0 Megalin/LRPAP1 -0.012 0.124 -9999.0 0.0 -0.328 18.0 18.0 PTCH2 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.032 0.092 -9999.0 0.0 -0.254 18.0 18.0 PTCH1 0.012 0.061 -9999.0 0.0 -0.293 4.0 4.0 HHIP -0.0 0.113 -9999.0 0.0 -0.457 8.0 8.0