Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.056 0.257 -9999.0 0.0 -0.604 11.0 11.0 IHH -0.032 0.154 -9999.0 0.0 -0.572 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.088 0.146 -9999.0 0.0 -0.27 27.0 27.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.088 0.145 0.268 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.051 0.213 -9999.0 0.0 -0.589 7.0 7.0 SMO -0.06 0.226 -9999.0 0.0 -0.628 7.0 7.0 AKT1 -0.012 0.105 -9999.0 0.0 -0.361 2.0 2.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.015 0.108 -9999.0 0.0 -0.461 4.0 4.0 ADRBK1 0.005 0.054 -9999.0 0.0 -0.448 1.0 1.0 heart looping -0.059 0.22 -9999.0 0.0 -0.614 7.0 7.0 STIL -0.031 0.19 -9999.0 0.0 -0.599 5.0 5.0 DHH N/PTCH2 -0.048 0.139 -9999.0 0.0 -0.345 13.0 13.0 DHH N/PTCH1 -0.06 0.189 -9999.0 0.0 -0.541 5.0 5.0 PIK3CA 0.004 0.06 -9999.0 0.0 -0.502 1.0 1.0 DHH -0.052 0.168 -9999.0 0.0 -0.496 9.0 9.0 PTHLH -0.089 0.334 -9999.0 0.0 -0.872 10.0 10.0 determination of left/right symmetry -0.059 0.22 -9999.0 0.0 -0.614 7.0 7.0 PIK3R1 0.005 0.054 -9999.0 0.0 -0.448 1.0 1.0 skeletal system development -0.087 0.328 -9999.0 0.0 -0.859 10.0 10.0 IHH N/Hhip -0.067 0.185 -9999.0 0.0 -0.425 14.0 14.0 DHH N/Hhip -0.081 0.194 -9999.0 0.0 -0.423 16.0 16.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.059 0.22 -9999.0 0.0 -0.614 7.0 7.0 pancreas development -0.066 0.181 -9999.0 0.0 -0.491 11.0 11.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.008 0.058 -9999.0 0.0 -0.333 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.137 0.225 -9999.0 0.0 -0.475 22.0 22.0 somite specification -0.059 0.22 -9999.0 0.0 -0.614 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.038 0.202 -9999.0 0.0 -0.64 5.0 5.0 SHH Np/Cholesterol/PTCH2 -0.021 0.117 -9999.0 0.0 -0.313 9.0 9.0 SHH Np/Cholesterol/Megalin -0.022 0.102 -9999.0 0.0 -0.282 9.0 9.0 SHH -0.017 0.109 -9999.0 0.0 -0.349 7.0 7.0 catabolic process -0.032 0.187 -9999.0 0.0 -0.401 11.0 11.0 SMO/Vitamin D3 -0.055 0.224 -9999.0 0.0 -0.62 7.0 7.0 SHH Np/Cholesterol/Hhip -0.049 0.137 -9999.0 0.0 -0.293 16.0 16.0 LRP2 -0.015 0.09 -9999.0 0.0 -0.448 3.0 3.0 receptor-mediated endocytosis -0.052 0.218 -9999.0 0.0 -0.706 5.0 5.0 SHH Np/Cholesterol/BOC -0.021 0.107 -9999.0 0.0 -0.278 10.0 10.0 SHH Np/Cholesterol/CDO -0.015 0.102 -9999.0 0.0 -0.295 8.0 8.0 mesenchymal cell differentiation 0.049 0.136 0.291 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 -0.036 0.204 -9999.0 0.0 -0.644 5.0 5.0 IHH N/PTCH2 -0.028 0.139 -9999.0 0.0 -0.392 8.0 8.0 CDON -0.003 0.084 -9999.0 0.0 -0.502 2.0 2.0 IHH N/PTCH1 -0.032 0.19 -9999.0 0.0 -0.406 11.0 11.0 Megalin/LRPAP1 -0.002 0.065 -9999.0 0.0 -0.311 3.0 3.0 PTCH2 -0.015 0.112 -9999.0 0.0 -0.475 4.0 4.0 SHH Np/Cholesterol -0.014 0.083 -9999.0 0.0 -0.267 7.0 7.0 PTCH1 -0.032 0.188 -9999.0 0.0 -0.403 11.0 11.0 HHIP -0.066 0.181 -9999.0 0.0 -0.492 11.0 11.0