Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	9.0	837.0	91.0	-0.516	0.427	1000.0	-1000.0	-0.11	-1000.0
TCGA08_p53	9.0	69.0	7.0	-0.062	0.031	1000.0	-1000.0	-0.015	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	402.0	44.0	-0.097	0.032	1000.0	-1000.0	-0.033	-1000.0
Ephrin B reverse signaling	7.0	352.0	48.0	-0.126	0.049	1000.0	-1000.0	-0.029	-1000.0
IL23-mediated signaling events	7.0	440.0	60.0	-0.353	0.036	1000.0	-1000.0	-0.103	-1000.0
Signaling events mediated by the Hedgehog family	6.0	312.0	52.0	-0.075	0.045	1000.0	-1000.0	-0.04	-1000.0
Endothelins	6.0	579.0	96.0	-0.094	0.038	1000.0	-1000.0	-0.052	-1000.0
IL12-mediated signaling events	5.0	450.0	87.0	-0.209	0.043	1000.0	-1000.0	-0.068	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	555.0	97.0	-0.174	0.064	1000.0	-1000.0	-0.054	-1000.0
TCR signaling in naïve CD8+ T cells	5.0	493.0	93.0	-0.075	0.047	1000.0	-1000.0	-0.042	-1000.0
Osteopontin-mediated events	4.0	163.0	38.0	-0.077	0.05	1000.0	-1000.0	-0.045	-1000.0
Thromboxane A2 receptor signaling	4.0	466.0	105.0	-0.076	0.032	1000.0	-1000.0	-0.038	-1000.0
HIF-1-alpha transcription factor network	4.0	326.0	76.0	-0.116	0.037	1000.0	-1000.0	-0.09	-1000.0
FOXA2 and FOXA3 transcription factor networks	4.0	220.0	46.0	-0.21	0.035	1000.0	-1000.0	-0.091	-1000.0
Glypican 1 network	4.0	208.0	48.0	-0.06	0.055	1000.0	-1000.0	-0.033	-1000.0
Reelin signaling pathway	4.0	266.0	56.0	-0.058	0.077	1000.0	-1000.0	-0.035	-1000.0
IL1-mediated signaling events	4.0	307.0	62.0	-0.044	0.117	1000.0	-1000.0	-0.066	-1000.0
LPA receptor mediated events	4.0	430.0	102.0	-0.116	0.04	1000.0	-1000.0	-0.059	-1000.0
BCR signaling pathway	4.0	485.0	99.0	-0.122	0.039	1000.0	-1000.0	-0.05	-1000.0
EGFR-dependent Endothelin signaling events	4.0	89.0	21.0	-0.047	0.045	1000.0	-1000.0	-0.043	-1000.0
Plasma membrane estrogen receptor signaling	4.0	417.0	86.0	-0.066	0.071	1000.0	-1000.0	-0.04	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	399.0	88.0	-0.061	0.046	1000.0	-1000.0	-0.051	-1000.0
PDGFR-beta signaling pathway	4.0	439.0	97.0	-0.095	0.073	1000.0	-1000.0	-0.055	-1000.0
Ephrin A  reverse signaling	3.0	24.0	7.0	-0.039	0.032	1000.0	-1000.0	-0.02	-1000.0
Noncanonical Wnt signaling pathway	3.0	93.0	26.0	-0.043	0.033	1000.0	-1000.0	-0.039	-1000.0
p75(NTR)-mediated signaling	3.0	376.0	125.0	-0.08	0.079	1000.0	-1000.0	-0.068	-1000.0
BMP receptor signaling	3.0	299.0	81.0	-0.064	0.052	1000.0	-1000.0	-0.033	-1000.0
amb2 Integrin signaling	3.0	268.0	82.0	-0.061	0.056	1000.0	-1000.0	-0.039	-1000.0
Glucocorticoid receptor regulatory network	3.0	445.0	114.0	-0.215	0.152	1000.0	-1000.0	-0.054	-1000.0
FAS signaling pathway (CD95)	3.0	156.0	47.0	-0.088	0.05	1000.0	-1000.0	-0.034	-1000.0
Retinoic acid receptors-mediated signaling	3.0	200.0	58.0	-0.088	0.044	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	3.0	298.0	85.0	-0.056	0.108	1000.0	-1000.0	-0.061	-1000.0
Effects of Botulinum toxin	3.0	81.0	26.0	-0.063	0.055	1000.0	-1000.0	-0.015	-1000.0
Nongenotropic Androgen signaling	3.0	157.0	52.0	-0.039	0.065	1000.0	-1000.0	-0.03	-1000.0
Wnt signaling	3.0	26.0	7.0	-0.043	0.029	1000.0	-1000.0	-0.018	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	212.0	68.0	-0.1	0.038	1000.0	-1000.0	-0.077	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	3.0	102.0	27.0	-0.058	0.031	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events	3.0	275.0	73.0	-0.054	0.032	1000.0	-1000.0	-0.033	-1000.0
Syndecan-4-mediated signaling events	3.0	266.0	67.0	-0.047	0.046	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	3.0	180.0	56.0	-0.01	0.093	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	283.0	78.0	-0.201	0.034	1000.0	-1000.0	-0.049	-1000.0
ErbB2/ErbB3 signaling events	2.0	158.0	65.0	-0.037	0.045	1000.0	-1000.0	-0.052	-1000.0
Caspase cascade in apoptosis	2.0	188.0	74.0	-0.055	0.046	1000.0	-1000.0	-0.034	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	2.0	69.0	34.0	-0.041	0.087	1000.0	-1000.0	-0.034	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	119.0	54.0	-0.05	0.046	1000.0	-1000.0	-0.048	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	39.0	17.0	-0.024	0.058	1000.0	-1000.0	-0.037	-1000.0
Syndecan-2-mediated signaling events	2.0	174.0	69.0	-0.02	0.057	1000.0	-1000.0	-0.037	-1000.0
Cellular roles of Anthrax toxin	2.0	102.0	39.0	-0.026	0.036	1000.0	-1000.0	-0.02	-1000.0
Arf6 signaling events	2.0	185.0	62.0	-0.058	0.072	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by PTP1B	2.0	225.0	76.0	-0.035	0.052	1000.0	-1000.0	-0.033	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	163.0	61.0	-0.047	0.07	1000.0	-1000.0	-0.035	-1000.0
mTOR signaling pathway	2.0	143.0	53.0	-0.064	0.034	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	158.0	68.0	-0.045	0.049	1000.0	-1000.0	-0.027	-1000.0
Ceramide signaling pathway	2.0	221.0	76.0	-0.045	0.074	1000.0	-1000.0	-0.032	-1000.0
S1P1 pathway	2.0	77.0	36.0	-0.03	0.054	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	2.0	94.0	35.0	-0.02	0.07	1000.0	-1000.0	-0.025	-1000.0
Canonical Wnt signaling pathway	2.0	136.0	51.0	-0.054	0.097	1000.0	-1000.0	-0.041	-1000.0
Regulation of p38-alpha and p38-beta	2.0	145.0	54.0	-0.069	0.056	1000.0	-1000.0	-0.042	-1000.0
IL27-mediated signaling events	2.0	120.0	51.0	-0.167	0.065	1000.0	-1000.0	-0.062	-1000.0
TCGA08_retinoblastoma	2.0	17.0	8.0	-0.002	0.034	1000.0	-1000.0	-0.005	-1000.0
S1P3 pathway	2.0	96.0	42.0	-0.023	0.049	1000.0	-1000.0	-0.028	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	346.0	120.0	-0.072	0.086	1000.0	-1000.0	-0.043	-1000.0
FOXM1 transcription factor network	2.0	123.0	51.0	-0.151	0.039	1000.0	-1000.0	-0.123	-1000.0
S1P4 pathway	2.0	59.0	25.0	-0.012	0.053	1000.0	-1000.0	-0.023	-1000.0
Regulation of Androgen receptor activity	2.0	157.0	70.0	-0.164	0.062	1000.0	-1000.0	-0.06	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	41.0	17.0	-0.016	0.031	1000.0	-1000.0	-0.025	-1000.0
Aurora B signaling	2.0	158.0	67.0	-0.181	0.06	1000.0	-1000.0	-0.036	-1000.0
LPA4-mediated signaling events	1.0	22.0	12.0	-0.03	0.006	1000.0	-1000.0	-0.023	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	167.0	136.0	-0.094	0.053	1000.0	-1000.0	-0.031	-1000.0
Coregulation of Androgen receptor activity	1.0	135.0	76.0	-0.078	0.059	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	1.0	107.0	75.0	-0.048	0.084	1000.0	-1000.0	-0.031	-1000.0
BARD1 signaling events	1.0	64.0	57.0	-0.035	0.07	1000.0	-1000.0	-0.04	-1000.0
Syndecan-1-mediated signaling events	1.0	64.0	34.0	-0.021	0.045	1000.0	-1000.0	-0.035	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	30.0	28.0	-0.025	0.052	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Cones	1.0	44.0	38.0	-0.018	0.052	1000.0	-1000.0	-0.025	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	6.0	5.0	0.016	0.046	1000.0	-1000.0	0.022	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	129.0	85.0	-0.037	0.077	1000.0	-1000.0	-0.039	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	112.0	65.0	-0.05	0.045	1000.0	-1000.0	-0.051	-1000.0
Arf6 downstream pathway	1.0	73.0	43.0	-0.033	0.039	1000.0	-1000.0	-0.025	-1000.0
EPO signaling pathway	1.0	96.0	55.0	-0.023	0.075	1000.0	-1000.0	-0.035	-1000.0
PLK1 signaling events	1.0	168.0	85.0	-0.018	0.062	1000.0	-1000.0	-0.027	-1000.0
Insulin-mediated glucose transport	1.0	50.0	32.0	-0.151	0.042	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	1.0	63.0	44.0	-0.016	0.072	1000.0	-1000.0	-0.034	-1000.0
IFN-gamma pathway	1.0	107.0	68.0	-0.054	0.065	1000.0	-1000.0	-0.057	-1000.0
Nectin adhesion pathway	1.0	94.0	63.0	-0.014	0.08	1000.0	-1000.0	-0.039	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	57.0	37.0	-0.016	0.077	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by HDAC Class III	1.0	46.0	40.0	-0.054	0.054	1000.0	-1000.0	-0.041	-1000.0
TRAIL signaling pathway	1.0	48.0	48.0	-0.025	0.055	1000.0	-1000.0	-0.03	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	136.0	82.0	-0.041	0.063	1000.0	-1000.0	-0.051	-1000.0
S1P5 pathway	1.0	26.0	17.0	-0.009	0.031	1000.0	-1000.0	-0.011	-1000.0
ceramide signaling pathway	1.0	65.0	49.0	-0.009	0.055	1000.0	-1000.0	-0.033	-1000.0
HIF-2-alpha transcription factor network	1.0	44.0	43.0	-0.068	0.069	1000.0	-1000.0	-0.048	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	130.0	83.0	-0.073	0.055	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class I	1.0	142.0	104.0	-0.06	0.069	1000.0	-1000.0	-0.04	-1000.0
FoxO family signaling	1.0	93.0	64.0	-0.043	0.065	1000.0	-1000.0	-0.058	-1000.0
IL2 signaling events mediated by PI3K	1.0	115.0	58.0	-0.037	0.045	1000.0	-1000.0	-0.045	-1000.0
Integrins in angiogenesis	1.0	137.0	84.0	-0.067	0.078	1000.0	-1000.0	-0.038	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	73.0	45.0	-0.034	0.082	1000.0	-1000.0	-0.037	-1000.0
Glypican 2 network	1.0	6.0	4.0	0.018	0.038	1000.0	-1000.0	0.022	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	53.0	31.0	-0.023	0.032	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	152.0	125.0	-0.024	0.095	1000.0	-1000.0	-0.045	-1000.0
TCGA08_rtk_signaling	1.0	37.0	26.0	-0.027	0.066	1000.0	-1000.0	-0.011	-1000.0
IL6-mediated signaling events	1.0	100.0	75.0	-0.01	0.077	1000.0	-1000.0	-0.054	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	82.0	74.0	-0.063	0.072	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	132.0	76.0	-0.026	0.083	1000.0	-1000.0	-0.055	-1000.0
IL2 signaling events mediated by STAT5	1.0	35.0	22.0	-0.034	0.033	1000.0	-1000.0	-0.044	-1000.0
Arf6 trafficking events	1.0	103.0	71.0	-0.054	0.056	1000.0	-1000.0	-0.034	-1000.0
Regulation of Telomerase	1.0	184.0	102.0	-0.093	0.054	1000.0	-1000.0	-0.046	-1000.0
IGF1 pathway	1.0	100.0	57.0	-0.039	0.067	1000.0	-1000.0	-0.05	-1000.0
Insulin Pathway	1.0	98.0	74.0	-0.047	0.09	1000.0	-1000.0	-0.055	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	55.0	33.0	-0.011	0.067	1000.0	-1000.0	-0.041	-1000.0
Visual signal transduction: Rods	1.0	98.0	52.0	-0.052	0.065	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by PRL	1.0	67.0	34.0	-0.025	0.073	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.026	0.026	1000.0	-1000.0	-0.017	-1000.0
Arf1 pathway	1.0	70.0	54.0	-0.007	0.064	1000.0	-1000.0	-0.017	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.002	0.034	1000.0	-1000.0	-0.028	-1000.0
Canonical NF-kappaB pathway	0.0	33.0	39.0	-0.015	0.063	1000.0	-1000.0	-0.031	-1000.0
ErbB4 signaling events	0.0	67.0	69.0	-0.042	0.07	1000.0	-1000.0	-0.051	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.021	-1000.0	1000.0	-1000.0	-0.024	-1000.0
Circadian rhythm pathway	0.0	0.0	22.0	-0.006	0.071	1000.0	-1000.0	-0.024	-1000.0
Aurora A signaling	0.0	27.0	60.0	-0.032	0.084	1000.0	-1000.0	-0.027	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.047	1000.0	-1000.0	-0.016	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	0.0	46.0	52.0	-0.025	0.099	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	14.0	15.0	-0.029	0.031	1000.0	-1000.0	-0.032	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.065	0.067	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	0.0	6.0	31.0	-0.014	0.051	1000.0	-1000.0	-0.027	-1000.0
Rapid glucocorticoid signaling	0.0	4.0	20.0	-0.01	0.038	1000.0	-1000.0	-0.014	-1000.0
E-cadherin signaling in keratinocytes	0.0	17.0	43.0	-0.04	0.091	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.031	0.061	1000.0	-1000.0	0.02	-1000.0
p38 MAPK signaling pathway	0.0	32.0	44.0	-0.024	0.071	1000.0	-1000.0	-0.019	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.086	1000.0	-1000.0	-0.0	-1000.0
Total	274	20249	7203	-7.88894231422	-992.112426387	131000	-131000	-4.98834702395	-131000