E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.099 0.185 0.229 1.0 -0.365 73.0 74.0 KLHL20 -0.031 0.093 0.18 5.0 -0.211 21.0 26.0 CYFIP2 0.014 0.067 -9999.0 0.0 -0.315 9.0 9.0 Rac1/GDP -0.046 0.117 0.209 3.0 -0.226 53.0 56.0 ENAH -0.095 0.181 0.224 1.0 -0.372 65.0 66.0 AP1M1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.019 0.082 -9999.0 0.0 -0.153 49.0 49.0 ABI1/Sra1/Nap1 -0.041 0.054 -9999.0 0.0 -0.143 27.0 27.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.007 0.115 -9999.0 0.0 -0.174 71.0 71.0 RAPGEF1 -0.081 0.166 0.22 3.0 -0.327 67.0 70.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.095 0.194 -9999.0 0.0 -0.373 75.0 75.0 CRK -0.087 0.175 0.216 1.0 -0.347 68.0 69.0 E-cadherin/gamma catenin/alpha catenin -0.011 0.113 -9999.0 0.0 -0.19 63.0 63.0 alphaE/beta7 Integrin 0.027 0.058 -9999.0 0.0 -0.214 12.0 12.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.029 -9999.0 0.0 -0.155 2.0 2.0 DLG1 -0.098 0.185 -9999.0 0.0 -0.365 74.0 74.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.046 -9999.0 0.0 -0.12 50.0 50.0 MLLT4 0.022 0.033 -9999.0 0.0 -0.315 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.041 0.05 -9999.0 0.0 -0.164 12.0 12.0 PI3K -0.05 0.059 -9999.0 0.0 -0.151 50.0 50.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.029 0.122 -9999.0 0.0 -0.225 63.0 63.0 TIAM1 0.01 0.076 -9999.0 0.0 -0.315 12.0 12.0 E-cadherin(dimer)/Ca2+ 0.003 0.102 -9999.0 0.0 -0.159 63.0 63.0 AKT1 -0.024 0.049 0.119 4.0 -0.124 1.0 5.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 CDH1 -0.061 0.156 0.124 12.0 -0.315 63.0 75.0 RhoA/GDP -0.044 0.127 0.241 5.0 -0.225 58.0 63.0 actin cytoskeleton organization -0.021 0.072 0.155 6.0 -0.154 21.0 27.0 CDC42/GDP -0.045 0.126 0.241 5.0 -0.225 58.0 63.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.037 0.094 -9999.0 0.0 -0.187 63.0 63.0 ITGB7 0.011 0.076 -9999.0 0.0 -0.315 12.0 12.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.004 0.109 -9999.0 0.0 -0.17 63.0 63.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.007 0.092 -9999.0 0.0 -0.155 63.0 63.0 mol:GDP -0.062 0.134 0.244 5.0 -0.254 58.0 63.0 CDC42/GTP/IQGAP1 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.035 -9999.0 0.0 -0.315 2.0 2.0 p120 catenin/RhoA/GDP -0.04 0.13 0.23 4.0 -0.231 56.0 60.0 RAC1/GTP/IQGAP1 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.011 0.056 0.135 8.0 -0.107 21.0 29.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.103 0.186 -9999.0 0.0 -0.367 75.0 75.0 regulation of cell-cell adhesion -0.025 0.065 -9999.0 0.0 -0.137 49.0 49.0 WASF2 -0.014 0.04 0.093 3.0 -0.087 14.0 17.0 Rap1/GTP -0.018 0.094 0.254 3.0 -0.166 50.0 53.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.0 0.118 -9999.0 0.0 -0.171 70.0 70.0 CCND1 -0.013 0.066 0.154 8.0 -0.129 21.0 29.0 VAV2 -0.121 0.247 0.356 1.0 -0.435 75.0 76.0 RAP1/GDP -0.025 0.107 0.264 3.0 -0.182 54.0 57.0 adherens junction assembly -0.099 0.181 -9999.0 0.0 -0.356 75.0 75.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.01 0.109 0.208 3.0 -0.167 70.0 73.0 E-cadherin/beta catenin -0.064 0.128 -9999.0 0.0 -0.275 62.0 62.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.096 0.181 0.224 1.0 -0.354 74.0 75.0 PIK3CA 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 Rac1/GTP -0.076 0.124 -9999.0 0.0 -0.334 24.0 24.0 E-cadherin/beta catenin/alpha catenin -0.01 0.109 -9999.0 0.0 -0.185 63.0 63.0 ITGAE 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.098 0.197 -9999.0 0.0 -0.38 75.0 75.0