Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.018 0.118 -9999.0 0.0 -0.447 12.0 12.0 IHH 0.033 0.053 0.145 6.0 -0.137 16.0 22.0 SHH Np/Cholesterol/GAS1 0.016 0.028 -9999.0 0.0 -0.168 4.0 4.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.016 0.027 0.167 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 0.013 0.129 -9999.0 0.0 -0.345 13.0 13.0 SMO -0.01 0.118 -9999.0 0.0 -0.363 14.0 14.0 AKT1 0.001 0.102 -9999.0 0.0 -0.365 10.0 10.0 ARRB2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.06 0.124 13.0 -0.315 6.0 19.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.01 0.117 -9999.0 0.0 -0.358 14.0 14.0 STIL 0.023 0.089 0.186 31.0 -0.229 13.0 44.0 DHH N/PTCH2 0.037 0.066 0.181 2.0 -0.219 12.0 14.0 DHH N/PTCH1 0.026 0.108 -9999.0 0.0 -0.292 20.0 20.0 PIK3CA 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 DHH 0.027 0.071 -9999.0 0.0 -0.315 8.0 8.0 PTHLH -0.0 0.175 -9999.0 0.0 -0.621 15.0 15.0 determination of left/right symmetry -0.01 0.117 -9999.0 0.0 -0.358 14.0 14.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 skeletal system development 0.0 0.173 -9999.0 0.0 -0.615 15.0 15.0 IHH N/Hhip 0.045 0.043 0.19 3.0 -9999.0 0.0 3.0 DHH N/Hhip 0.042 0.058 0.181 3.0 -0.219 8.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.01 0.117 -9999.0 0.0 -0.358 14.0 14.0 pancreas development 0.032 0.026 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.019 0.05 -9999.0 0.0 -0.315 5.0 5.0 PI3K 0.036 0.039 -9999.0 0.0 -0.279 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.024 0.033 0.124 1.0 -0.315 2.0 3.0 somite specification -0.01 0.117 -9999.0 0.0 -0.358 14.0 14.0 SHH Np/Cholesterol/PTCH1 0.01 0.069 -9999.0 0.0 -0.224 15.0 15.0 SHH Np/Cholesterol/PTCH2 0.017 0.036 0.159 2.0 -0.169 6.0 8.0 SHH Np/Cholesterol/Megalin 0.003 0.102 0.194 12.0 -0.171 49.0 61.0 SHH -0.013 0.027 -9999.0 0.0 -0.222 3.0 3.0 catabolic process 0.011 0.104 0.178 1.0 -0.355 16.0 17.0 SMO/Vitamin D3 0.01 0.099 0.216 11.0 -0.28 14.0 25.0 SHH Np/Cholesterol/Hhip 0.016 0.039 0.167 5.0 -0.167 3.0 8.0 LRP2 -0.027 0.171 -9999.0 0.0 -0.315 58.0 58.0 receptor-mediated endocytosis -0.025 0.119 0.207 3.0 -0.303 22.0 25.0 SHH Np/Cholesterol/BOC 0.018 0.04 0.202 1.0 -0.169 7.0 8.0 SHH Np/Cholesterol/CDO 0.014 0.035 -9999.0 0.0 -0.197 5.0 5.0 mesenchymal cell differentiation -0.015 0.038 0.166 3.0 -0.165 5.0 8.0 mol:Vitamin D3 0.038 0.099 0.214 32.0 -0.238 13.0 45.0 IHH N/PTCH2 0.039 0.053 0.204 1.0 -0.236 4.0 5.0 CDON 0.021 0.04 -9999.0 0.0 -0.315 3.0 3.0 IHH N/PTCH1 0.023 0.109 0.23 1.0 -0.357 16.0 17.0 Megalin/LRPAP1 -0.003 0.128 -9999.0 0.0 -0.219 58.0 58.0 PTCH2 0.025 0.048 0.124 6.0 -0.315 4.0 10.0 SHH Np/Cholesterol 0.01 0.021 -9999.0 0.0 -0.165 3.0 3.0 PTCH1 0.011 0.104 0.178 1.0 -0.356 16.0 17.0 HHIP 0.032 0.026 -9999.0 0.0 -9999.0 0.0 0.0