Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	7.0	362.0	46.0	-0.468	0.043	1000.0	-1000.0	-0.119	-1000.0
Ephrin A  reverse signaling	5.0	36.0	7.0	-0.059	0.0	1000.0	-1000.0	-0.02	-1000.0
IL23-mediated signaling events	5.0	347.0	60.0	-0.401	0.04	1000.0	-1000.0	-0.112	-1000.0
Signaling events mediated by the Hedgehog family	4.0	223.0	52.0	-0.074	0.047	1000.0	-1000.0	-0.036	-1000.0
IL4-mediated signaling events	4.0	375.0	91.0	-0.487	0.342	1000.0	-1000.0	-0.134	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	333.0	82.0	-0.05	0.039	1000.0	-1000.0	-0.044	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	3.0	109.0	34.0	-0.031	0.057	1000.0	-1000.0	-0.037	-1000.0
TCGA08_p53	3.0	25.0	7.0	-0.049	0.034	1000.0	-1000.0	-0.013	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	132.0	44.0	-0.044	0.037	1000.0	-1000.0	-0.021	-1000.0
TCR signaling in naïve CD8+ T cells	3.0	313.0	93.0	-0.097	0.051	1000.0	-1000.0	-0.052	-1000.0
Visual signal transduction: Rods	3.0	166.0	52.0	-0.094	0.057	1000.0	-1000.0	-0.031	-1000.0
ErbB2/ErbB3 signaling events	2.0	158.0	65.0	-0.047	0.051	1000.0	-1000.0	-0.084	-1000.0
Visual signal transduction: Cones	2.0	99.0	38.0	-0.044	0.057	1000.0	-1000.0	-0.024	-1000.0
Noncanonical Wnt signaling pathway	2.0	54.0	26.0	-0.038	0.037	1000.0	-1000.0	-0.041	-1000.0
p75(NTR)-mediated signaling	2.0	374.0	125.0	-0.074	0.09	1000.0	-1000.0	-0.065	-1000.0
BMP receptor signaling	2.0	228.0	81.0	-0.085	0.068	1000.0	-1000.0	-0.037	-1000.0
Glypican 1 network	2.0	141.0	48.0	-0.073	0.063	1000.0	-1000.0	-0.03	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	290.0	97.0	-0.106	0.059	1000.0	-1000.0	-0.07	-1000.0
Glucocorticoid receptor regulatory network	2.0	340.0	114.0	-0.376	0.173	1000.0	-1000.0	-0.055	-1000.0
IL1-mediated signaling events	2.0	140.0	62.0	-0.077	0.088	1000.0	-1000.0	-0.032	-1000.0
FAS signaling pathway (CD95)	2.0	105.0	47.0	-0.16	0.068	1000.0	-1000.0	-0.053	-1000.0
EPHB forward signaling	2.0	196.0	85.0	-0.051	0.083	1000.0	-1000.0	-0.062	-1000.0
Effects of Botulinum toxin	2.0	53.0	26.0	-0.029	0.035	1000.0	-1000.0	-0.015	-1000.0
BCR signaling pathway	2.0	245.0	99.0	-0.101	0.044	1000.0	-1000.0	-0.073	-1000.0
Syndecan-4-mediated signaling events	2.0	153.0	67.0	-0.045	0.05	1000.0	-1000.0	-0.043	-1000.0
LPA4-mediated signaling events	1.0	13.0	12.0	-0.043	0.011	1000.0	-1000.0	-0.022	-1000.0
Caspase cascade in apoptosis	1.0	144.0	74.0	-0.146	0.08	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	1.0	94.0	76.0	-0.097	0.067	1000.0	-1000.0	-0.022	-1000.0
IL12-mediated signaling events	1.0	134.0	87.0	-0.126	0.067	1000.0	-1000.0	-0.089	-1000.0
ErbB4 signaling events	1.0	81.0	69.0	-0.053	0.051	1000.0	-1000.0	-0.038	-1000.0
Syndecan-1-mediated signaling events	1.0	51.0	34.0	-0.023	0.051	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	18.0	17.0	-0.029	0.087	1000.0	-1000.0	-0.043	-1000.0
Thromboxane A2 receptor signaling	1.0	130.0	105.0	-0.037	0.049	1000.0	-1000.0	-0.046	-1000.0
HIF-1-alpha transcription factor network	1.0	126.0	76.0	-0.102	0.046	1000.0	-1000.0	-0.082	-1000.0
Syndecan-2-mediated signaling events	1.0	85.0	69.0	-0.029	0.082	1000.0	-1000.0	-0.04	-1000.0
Cellular roles of Anthrax toxin	1.0	41.0	39.0	-0.039	0.039	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by PTP1B	1.0	87.0	76.0	-0.076	0.057	1000.0	-1000.0	-0.033	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	75.0	61.0	-0.091	0.09	1000.0	-1000.0	-0.052	-1000.0
EPO signaling pathway	1.0	55.0	55.0	0.007	0.071	1000.0	-1000.0	-0.03	-1000.0
PLK1 signaling events	1.0	110.0	85.0	-0.02	0.061	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	1.0	106.0	68.0	-0.096	0.052	1000.0	-1000.0	-0.054	-1000.0
amb2 Integrin signaling	1.0	142.0	82.0	-0.092	0.061	1000.0	-1000.0	-0.038	-1000.0
Reelin signaling pathway	1.0	100.0	56.0	-0.041	0.084	1000.0	-1000.0	-0.034	-1000.0
ceramide signaling pathway	1.0	80.0	49.0	-0.013	0.054	1000.0	-1000.0	-0.03	-1000.0
Ephrin B reverse signaling	1.0	71.0	48.0	-0.042	0.056	1000.0	-1000.0	-0.032	-1000.0
Endothelins	1.0	191.0	96.0	-0.099	0.059	1000.0	-1000.0	-0.052	-1000.0
S1P1 pathway	1.0	37.0	36.0	-0.085	0.037	1000.0	-1000.0	-0.035	-1000.0
Retinoic acid receptors-mediated signaling	1.0	58.0	58.0	-0.038	0.066	1000.0	-1000.0	-0.049	-1000.0
Syndecan-3-mediated signaling events	1.0	44.0	35.0	-0.029	0.09	1000.0	-1000.0	-0.016	-1000.0
IL2 signaling events mediated by PI3K	1.0	77.0	58.0	-0.124	0.055	1000.0	-1000.0	-0.05	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	64.0	45.0	-0.042	0.087	1000.0	-1000.0	-0.043	-1000.0
Canonical Wnt signaling pathway	1.0	81.0	51.0	-0.091	0.198	1000.0	-1000.0	-0.044	-1000.0
Glypican 2 network	1.0	6.0	4.0	0.012	0.031	1000.0	-1000.0	0.024	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	44.0	31.0	-0.054	0.039	1000.0	-1000.0	-0.05	-1000.0
IL27-mediated signaling events	1.0	98.0	51.0	-0.167	0.061	1000.0	-1000.0	-0.051	-1000.0
Wnt signaling	1.0	13.0	7.0	-0.038	0.027	1000.0	-1000.0	-0.024	-1000.0
IL6-mediated signaling events	1.0	89.0	75.0	-0.143	0.055	1000.0	-1000.0	-0.061	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	1.0	78.0	68.0	-0.146	0.039	1000.0	-1000.0	-0.104	-1000.0
TCGA08_retinoblastoma	1.0	14.0	8.0	-0.006	0.035	1000.0	-1000.0	-0.007	-1000.0
Regulation of Telomerase	1.0	123.0	102.0	-0.183	0.078	1000.0	-1000.0	-0.054	-1000.0
EGFR-dependent Endothelin signaling events	1.0	23.0	21.0	-0.03	0.071	1000.0	-1000.0	-0.039	-1000.0
Plasma membrane estrogen receptor signaling	1.0	105.0	86.0	-0.06	0.069	1000.0	-1000.0	-0.052	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	235.0	120.0	-0.072	0.087	1000.0	-1000.0	-0.055	-1000.0
FOXM1 transcription factor network	1.0	51.0	51.0	-0.058	0.068	1000.0	-1000.0	-0.137	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	95.0	78.0	-0.099	0.049	1000.0	-1000.0	-0.06	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	17.0	17.0	-0.023	0.056	1000.0	-1000.0	-0.04	-1000.0
Aurora B signaling	1.0	79.0	67.0	-0.204	0.092	1000.0	-1000.0	-0.037	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	88.0	136.0	-0.148	0.083	1000.0	-1000.0	-0.033	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	3.0	23.0	0.012	0.06	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	0.0	11.0	39.0	-0.016	0.074	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by HDAC Class II	0.0	6.0	75.0	-0.033	0.092	1000.0	-1000.0	-0.026	-1000.0
BARD1 signaling events	0.0	30.0	57.0	-0.054	0.073	1000.0	-1000.0	-0.041	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	11.0	28.0	-0.016	0.066	1000.0	-1000.0	-0.026	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	-0.013	0.035	1000.0	-1000.0	-0.025	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.005	0.072	1000.0	-1000.0	-0.043	-1000.0
Osteopontin-mediated events	0.0	25.0	38.0	-0.037	0.067	1000.0	-1000.0	-0.044	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	52.0	54.0	-0.047	0.051	1000.0	-1000.0	-0.03	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.025	0.043	1000.0	-1000.0	0.027	-1000.0
Arf6 signaling events	0.0	50.0	62.0	-0.047	0.089	1000.0	-1000.0	-0.031	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	71.0	85.0	-0.018	0.078	1000.0	-1000.0	-0.047	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	59.0	65.0	-0.123	0.073	1000.0	-1000.0	-0.049	-1000.0
Aurora A signaling	0.0	40.0	60.0	-0.056	0.068	1000.0	-1000.0	-0.025	-1000.0
Arf6 downstream pathway	0.0	36.0	43.0	-0.059	0.06	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.0	0.048	1000.0	-1000.0	-0.012	-1000.0
Insulin-mediated glucose transport	0.0	13.0	32.0	-0.053	0.064	1000.0	-1000.0	-0.034	-1000.0
PDGFR-alpha signaling pathway	0.0	6.0	44.0	-0.027	0.078	1000.0	-1000.0	-0.038	-1000.0
mTOR signaling pathway	0.0	39.0	53.0	-0.069	0.052	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	63.0	68.0	-0.04	0.061	1000.0	-1000.0	-0.03	-1000.0
Nectin adhesion pathway	0.0	57.0	63.0	-0.023	0.069	1000.0	-1000.0	-0.051	-1000.0
Ceramide signaling pathway	0.0	56.0	76.0	-0.017	0.089	1000.0	-1000.0	-0.037	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	24.0	37.0	-0.016	0.075	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class III	0.0	29.0	40.0	-0.068	0.069	1000.0	-1000.0	-0.041	-1000.0
TRAIL signaling pathway	0.0	33.0	48.0	-0.022	0.066	1000.0	-1000.0	-0.026	-1000.0
S1P5 pathway	0.0	16.0	17.0	-0.009	0.046	1000.0	-1000.0	-0.008	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	0.0	46.0	52.0	-0.01	0.086	1000.0	-1000.0	-0.039	-1000.0
HIF-2-alpha transcription factor network	0.0	21.0	43.0	-0.085	0.087	1000.0	-1000.0	-0.055	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	43.0	83.0	-0.028	0.068	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class I	0.0	49.0	104.0	-0.062	0.086	1000.0	-1000.0	-0.041	-1000.0
FoxO family signaling	0.0	55.0	64.0	-0.106	0.05	1000.0	-1000.0	-0.073	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	11.0	15.0	-0.017	0.036	1000.0	-1000.0	-0.029	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	17.0	36.0	-0.061	0.071	1000.0	-1000.0	-0.037	-1000.0
Atypical NF-kappaB pathway	0.0	4.0	31.0	-0.014	0.047	1000.0	-1000.0	-0.021	-1000.0
Integrins in angiogenesis	0.0	54.0	84.0	-0.02	0.089	1000.0	-1000.0	-0.036	-1000.0
Regulation of p38-alpha and p38-beta	0.0	52.0	54.0	-0.065	0.086	1000.0	-1000.0	-0.047	-1000.0
Nongenotropic Androgen signaling	0.0	48.0	52.0	-0.03	0.056	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	16.0	125.0	-0.016	0.091	1000.0	-1000.0	-0.045	-1000.0
TCGA08_rtk_signaling	0.0	8.0	26.0	-0.053	0.087	1000.0	-1000.0	-0.005	-1000.0
LPA receptor mediated events	0.0	93.0	102.0	-0.054	0.069	1000.0	-1000.0	-0.085	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	68.0	74.0	-0.111	0.083	1000.0	-1000.0	-0.057	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	72.0	76.0	-0.025	0.073	1000.0	-1000.0	-0.05	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.019	0.075	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by STAT5	0.0	15.0	22.0	-0.016	0.037	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events	0.0	41.0	73.0	-0.017	0.061	1000.0	-1000.0	-0.042	-1000.0
Arf6 trafficking events	0.0	22.0	71.0	-0.059	0.066	1000.0	-1000.0	-0.038	-1000.0
IGF1 pathway	0.0	20.0	57.0	-0.013	0.099	1000.0	-1000.0	-0.03	-1000.0
Insulin Pathway	0.0	38.0	74.0	-0.032	0.085	1000.0	-1000.0	-0.041	-1000.0
VEGFR1 specific signals	0.0	16.0	56.0	-0.016	0.086	1000.0	-1000.0	-0.04	-1000.0
S1P3 pathway	0.0	28.0	42.0	-0.012	0.061	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	28.0	88.0	-0.047	0.086	1000.0	-1000.0	-0.077	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	26.0	33.0	-0.0	0.084	1000.0	-1000.0	-0.036	-1000.0
Rapid glucocorticoid signaling	0.0	4.0	20.0	-0.01	0.045	1000.0	-1000.0	-0.014	-1000.0
PDGFR-beta signaling pathway	0.0	73.0	97.0	-0.053	0.087	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by PRL	0.0	14.0	34.0	-0.04	0.05	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling in keratinocytes	0.0	32.0	43.0	-0.022	0.055	1000.0	-1000.0	-0.021	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.035	0.035	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	0.0	23.0	25.0	-0.01	0.065	1000.0	-1000.0	-0.021	-1000.0
E-cadherin signaling events	0.0	3.0	5.0	0.024	0.056	1000.0	-1000.0	0.025	-1000.0
p38 MAPK signaling pathway	0.0	10.0	44.0	-0.029	0.076	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.007	0.068	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.086	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	65.0	70.0	-0.147	0.041	1000.0	-1000.0	-0.055	-1000.0
Total	114	10318	7203	-8.42586429698	8.74797594814	131000	-131000	-5.29494320193	-131000