Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.127 0.272 -9999.0 0.0 -0.719 27.0 27.0 IHH -0.232 0.394 -9999.0 0.0 -0.878 102.0 102.0 SHH Np/Cholesterol/GAS1 -0.116 0.221 -9999.0 0.0 -0.544 79.0 79.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.115 0.219 0.54 79.0 -9999.0 0.0 79.0 SMO/beta Arrestin2 -0.112 0.256 -9999.0 0.0 -0.505 104.0 104.0 SMO -0.124 0.269 -9999.0 0.0 -0.537 105.0 105.0 AKT1 -0.032 0.121 -9999.0 0.0 -0.331 1.0 1.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.005 0.125 -9999.0 0.0 -0.856 8.0 8.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.122 0.265 -9999.0 0.0 -0.528 105.0 105.0 STIL -0.092 0.209 -9999.0 0.0 -0.595 16.0 16.0 DHH N/PTCH2 -0.104 0.245 -9999.0 0.0 -0.671 59.0 59.0 DHH N/PTCH1 -0.117 0.242 -9999.0 0.0 -0.48 107.0 107.0 PIK3CA 0.011 0.045 -9999.0 0.0 -0.856 1.0 1.0 DHH 0.006 0.077 -9999.0 0.0 -0.856 3.0 3.0 PTHLH -0.176 0.383 -9999.0 0.0 -1.22 27.0 27.0 determination of left/right symmetry -0.122 0.265 -9999.0 0.0 -0.528 105.0 105.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.173 0.376 -9999.0 0.0 -1.19 27.0 27.0 IHH N/Hhip -0.432 0.42 -9999.0 0.0 -0.778 213.0 213.0 DHH N/Hhip -0.278 0.331 -9999.0 0.0 -0.668 157.0 157.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.122 0.265 -9999.0 0.0 -0.528 105.0 105.0 pancreas development -0.348 0.424 -9999.0 0.0 -0.847 158.0 158.0 HHAT 0.011 0.045 -9999.0 0.0 -0.856 1.0 1.0 PI3K -0.002 0.034 -9999.0 0.0 -0.662 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.166 0.351 -9999.0 0.0 -0.856 78.0 78.0 somite specification -0.122 0.265 -9999.0 0.0 -0.528 105.0 105.0 SHH Np/Cholesterol/PTCH1 -0.104 0.218 -9999.0 0.0 -0.431 105.0 105.0 SHH Np/Cholesterol/PTCH2 -0.086 0.195 -9999.0 0.0 -0.542 58.0 58.0 SHH Np/Cholesterol/Megalin -0.143 0.238 -9999.0 0.0 -0.545 98.0 98.0 SHH 0.007 0.05 -9999.0 0.0 -0.662 1.0 1.0 catabolic process -0.133 0.266 -9999.0 0.0 -0.539 104.0 104.0 SMO/Vitamin D3 -0.107 0.238 -9999.0 0.0 -0.467 105.0 105.0 SHH Np/Cholesterol/Hhip -0.227 0.263 -9999.0 0.0 -0.538 157.0 157.0 LRP2 -0.209 0.379 -9999.0 0.0 -0.856 97.0 97.0 receptor-mediated endocytosis -0.212 0.244 -9999.0 0.0 -0.743 37.0 37.0 SHH Np/Cholesterol/BOC -0.017 0.086 -9999.0 0.0 -0.551 9.0 9.0 SHH Np/Cholesterol/CDO -0.16 0.245 -9999.0 0.0 -0.542 110.0 110.0 mesenchymal cell differentiation 0.226 0.261 0.534 157.0 -9999.0 0.0 157.0 mol:Vitamin D3 -0.103 0.222 -9999.0 0.0 -0.437 105.0 105.0 IHH N/PTCH2 -0.249 0.358 -9999.0 0.0 -0.685 144.0 144.0 CDON -0.237 0.393 -9999.0 0.0 -0.856 109.0 109.0 IHH N/PTCH1 -0.135 0.269 -9999.0 0.0 -0.546 104.0 104.0 Megalin/LRPAP1 -0.169 0.289 -9999.0 0.0 -0.662 97.0 97.0 PTCH2 -0.118 0.311 -9999.0 0.0 -0.856 57.0 57.0 SHH Np/Cholesterol -0.006 0.037 -9999.0 0.0 -0.54 1.0 1.0 PTCH1 -0.133 0.267 -9999.0 0.0 -0.541 104.0 104.0 HHIP -0.349 0.425 -9999.0 0.0 -0.849 158.0 158.0