Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.053 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.021 0.085 0.478 9.0 -9999.0 0.0 9.0 EGFR 0.016 0.082 -9999.0 0.0 -0.691 5.0 5.0 EPHA2 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.032 0.074 0.444 10.0 -9999.0 0.0 10.0 CTNNB1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.051 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.001 0.111 -9999.0 0.0 -0.546 14.0 14.0 CTNND1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.024 0.054 0.407 6.0 -9999.0 0.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.006 0.061 0.389 6.0 -9999.0 0.0 6.0 EGF -0.072 0.244 -9999.0 0.0 -0.685 51.0 51.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.047 0.178 -9999.0 0.0 -0.547 39.0 39.0 cortical microtubule organization 0.053 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.012 0.054 0.397 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.059 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.013 0.018 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.018 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.065 0.027 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.012 0.148 -9999.0 0.0 -0.371 54.0 54.0 RhoA/GDP 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.02 0.059 0.413 7.0 -9999.0 0.0 7.0 IGF-1R heterotetramer 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.117 0.284 -9999.0 0.0 -0.687 74.0 74.0 DIAPH1 0.048 0.05 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.053 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.021 0.059 0.416 7.0 -9999.0 0.0 7.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.013 0.041 0.353 2.0 -0.372 1.0 3.0 Ephrin A1/EPHA2 0.046 0.019 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.007 0.062 0.392 6.0 -9999.0 0.0 6.0 HGF/MET -0.0 0.144 -9999.0 0.0 -0.39 43.0 43.0 HGF -0.065 0.237 -9999.0 0.0 -0.691 47.0 47.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.068 0.145 0.552 22.0 -0.333 1.0 23.0 KIAA1543 0.012 0.055 0.37 6.0 -0.365 1.0 7.0 KIFC3 0.019 0.024 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.023 0.04 0.354 3.0 -9999.0 0.0 3.0 NCK1/GIT1 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.053 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.019 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.054 0.41 6.0 -9999.0 0.0 6.0 LIMA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.044 0.11 0.442 19.0 -9999.0 0.0 19.0 adherens junction assembly 0.027 0.094 0.479 11.0 -9999.0 0.0 11.0 IGF-1R heterotetramer/IGF1 -0.032 0.164 -9999.0 0.0 -0.37 69.0 69.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.029 0.065 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.024 0.055 0.38 6.0 -0.382 1.0 7.0 mol:GTP 0.058 0.023 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.027 0.065 0.501 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.02 0.059 0.413 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0