Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.175 0.265 -9999.0 0.0 -0.706 54.0 54.0 IHH -0.259 0.27 -9999.0 0.0 -0.523 184.0 184.0 SHH Np/Cholesterol/GAS1 -0.104 0.175 -9999.0 0.0 -0.314 138.0 138.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.103 0.174 0.312 138.0 -9999.0 0.0 138.0 SMO/beta Arrestin2 -0.156 0.219 -9999.0 0.0 -0.524 58.0 58.0 SMO -0.17 0.23 -9999.0 0.0 -0.552 60.0 60.0 AKT1 -0.083 0.153 -9999.0 0.0 -0.581 18.0 18.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.019 0.119 -9999.0 0.0 -0.469 24.0 24.0 ADRBK1 0.011 0.024 -9999.0 0.0 -0.451 1.0 1.0 heart looping -0.168 0.226 -9999.0 0.0 -0.542 60.0 60.0 STIL -0.157 0.204 -9999.0 0.0 -0.51 65.0 65.0 DHH N/PTCH2 -0.026 0.134 -9999.0 0.0 -0.407 38.0 38.0 DHH N/PTCH1 -0.15 0.193 -9999.0 0.0 -0.512 45.0 45.0 PIK3CA 0.01 0.034 -9999.0 0.0 -0.451 2.0 2.0 DHH -0.024 0.132 -9999.0 0.0 -0.514 25.0 25.0 PTHLH -0.204 0.313 -9999.0 0.0 -0.843 49.0 49.0 determination of left/right symmetry -0.168 0.226 -9999.0 0.0 -0.542 60.0 60.0 PIK3R1 -0.018 0.124 -9999.0 0.0 -0.522 21.0 21.0 skeletal system development -0.201 0.309 -9999.0 0.0 -0.831 49.0 49.0 IHH N/Hhip -0.223 0.235 -9999.0 0.0 -0.393 215.0 215.0 DHH N/Hhip -0.088 0.181 -9999.0 0.0 -0.383 97.0 97.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.168 0.226 -9999.0 0.0 -0.542 60.0 60.0 pancreas development -0.099 0.214 -9999.0 0.0 -0.511 78.0 78.0 HHAT -0.004 0.093 -9999.0 0.0 -0.538 11.0 11.0 PI3K -0.006 0.093 -9999.0 0.0 -0.366 23.0 23.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.09 0.203 -9999.0 0.0 -0.491 75.0 75.0 somite specification -0.168 0.226 -9999.0 0.0 -0.542 60.0 60.0 SHH Np/Cholesterol/PTCH1 -0.17 0.214 -9999.0 0.0 -0.53 69.0 69.0 SHH Np/Cholesterol/PTCH2 -0.063 0.148 -9999.0 0.0 -0.298 97.0 97.0 SHH Np/Cholesterol/Megalin -0.158 0.188 -9999.0 0.0 -0.315 197.0 197.0 SHH -0.072 0.169 -9999.0 0.0 -0.374 85.0 85.0 catabolic process -0.154 0.198 -9999.0 0.0 -0.548 35.0 35.0 SMO/Vitamin D3 -0.179 0.232 -9999.0 0.0 -0.575 66.0 66.0 SHH Np/Cholesterol/Hhip -0.11 0.175 -9999.0 0.0 -0.308 147.0 147.0 LRP2 -0.189 0.246 -9999.0 0.0 -0.487 149.0 149.0 receptor-mediated endocytosis -0.237 0.241 -9999.0 0.0 -0.557 99.0 99.0 SHH Np/Cholesterol/BOC -0.065 0.152 -9999.0 0.0 -0.298 100.0 100.0 SHH Np/Cholesterol/CDO -0.058 0.151 -9999.0 0.0 -0.306 89.0 89.0 mesenchymal cell differentiation 0.109 0.174 0.306 147.0 -9999.0 0.0 147.0 mol:Vitamin D3 -0.17 0.216 -9999.0 0.0 -0.532 69.0 69.0 IHH N/PTCH2 -0.163 0.184 -9999.0 0.0 -0.37 132.0 132.0 CDON -0.005 0.092 -9999.0 0.0 -0.485 13.0 13.0 IHH N/PTCH1 -0.155 0.201 -9999.0 0.0 -0.555 35.0 35.0 Megalin/LRPAP1 -0.127 0.178 -9999.0 0.0 -0.342 149.0 149.0 PTCH2 -0.014 0.113 -9999.0 0.0 -0.497 19.0 19.0 SHH Np/Cholesterol -0.056 0.131 -9999.0 0.0 -0.288 85.0 85.0 PTCH1 -0.154 0.199 -9999.0 0.0 -0.55 35.0 35.0 HHIP -0.099 0.214 -9999.0 0.0 -0.511 78.0 78.0