Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.09 0.186 -9999.0 0.0 -0.57 33.0 33.0 IHH -0.132 0.202 -9999.0 0.0 -0.428 108.0 108.0 SHH Np/Cholesterol/GAS1 -0.038 0.101 -9999.0 0.0 -0.242 65.0 65.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.037 0.1 0.24 65.0 -9999.0 0.0 65.0 SMO/beta Arrestin2 -0.092 0.191 -9999.0 0.0 -0.36 102.0 102.0 SMO -0.108 0.19 -9999.0 0.0 -0.375 105.0 105.0 AKT1 -0.052 0.161 -9999.0 0.0 -0.498 29.0 29.0 ARRB2 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.05 -9999.0 0.0 -0.403 4.0 4.0 ADRBK1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.106 0.187 -9999.0 0.0 -0.37 105.0 105.0 STIL -0.071 0.16 0.185 25.0 -0.331 62.0 87.0 DHH N/PTCH2 0.009 0.092 -9999.0 0.0 -0.315 25.0 25.0 DHH N/PTCH1 -0.075 0.149 -9999.0 0.0 -0.264 122.0 122.0 PIK3CA 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.001 0.094 -9999.0 0.0 -0.403 18.0 18.0 PTHLH -0.122 0.234 -9999.0 0.0 -0.62 41.0 41.0 determination of left/right symmetry -0.106 0.187 -9999.0 0.0 -0.37 105.0 105.0 PIK3R1 0.003 0.091 -9999.0 0.0 -0.403 17.0 17.0 skeletal system development -0.121 0.231 -9999.0 0.0 -0.614 41.0 41.0 IHH N/Hhip -0.098 0.182 -9999.0 0.0 -0.328 125.0 125.0 DHH N/Hhip -0.03 0.129 -9999.0 0.0 -0.301 63.0 63.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.106 0.187 -9999.0 0.0 -0.37 105.0 105.0 pancreas development -0.042 0.147 -9999.0 0.0 -0.403 50.0 50.0 HHAT 0.011 0.067 -9999.0 0.0 -0.403 9.0 9.0 PI3K 0.025 0.052 -9999.0 0.0 -0.285 9.0 9.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.024 0.121 -9999.0 0.0 -0.403 31.0 31.0 somite specification -0.106 0.187 -9999.0 0.0 -0.37 105.0 105.0 SHH Np/Cholesterol/PTCH1 -0.087 0.151 -9999.0 0.0 -0.286 105.0 105.0 SHH Np/Cholesterol/PTCH2 -0.021 0.092 -9999.0 0.0 -0.244 47.0 47.0 SHH Np/Cholesterol/Megalin -0.058 0.113 -9999.0 0.0 -0.249 83.0 83.0 SHH -0.035 0.103 -9999.0 0.0 -0.302 44.0 44.0 catabolic process -0.076 0.15 -9999.0 0.0 -0.287 110.0 110.0 SMO/Vitamin D3 -0.083 0.195 -9999.0 0.0 -0.338 110.0 110.0 SHH Np/Cholesterol/Hhip -0.048 0.115 -9999.0 0.0 -0.255 77.0 77.0 LRP2 -0.071 0.154 -9999.0 0.0 -0.403 60.0 60.0 receptor-mediated endocytosis -0.119 0.196 -9999.0 0.0 -0.403 83.0 83.0 SHH Np/Cholesterol/BOC -0.02 0.088 -9999.0 0.0 -0.236 46.0 46.0 SHH Np/Cholesterol/CDO -0.019 0.092 -9999.0 0.0 -0.248 45.0 45.0 mesenchymal cell differentiation 0.048 0.114 0.253 77.0 -9999.0 0.0 77.0 mol:Vitamin D3 -0.065 0.175 0.205 34.0 -0.321 77.0 111.0 IHH N/PTCH2 -0.059 0.142 -9999.0 0.0 -0.27 106.0 106.0 CDON 0.017 0.052 -9999.0 0.0 -0.403 5.0 5.0 IHH N/PTCH1 -0.074 0.16 -9999.0 0.0 -0.284 121.0 121.0 Megalin/LRPAP1 -0.038 0.116 -9999.0 0.0 -0.285 60.0 60.0 PTCH2 0.011 0.072 -9999.0 0.0 -0.403 10.0 10.0 SHH Np/Cholesterol -0.022 0.08 -9999.0 0.0 -0.228 44.0 44.0 PTCH1 -0.076 0.151 -9999.0 0.0 -0.288 110.0 110.0 HHIP -0.042 0.147 -9999.0 0.0 -0.403 50.0 50.0