Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.038 -9999.0 0.0 -0.234 7.0 7.0 epithelial cell differentiation 0.043 0.037 -9999.0 0.0 -0.201 6.0 6.0 CYFIP2 0.014 0.067 -9999.0 0.0 -0.403 9.0 9.0 ENAH -0.007 0.062 0.272 7.0 -0.286 3.0 10.0 EGFR 0.013 0.07 -9999.0 0.0 -0.403 10.0 10.0 EPHA2 0.017 0.056 -9999.0 0.0 -0.403 6.0 6.0 MYO6 -0.011 0.043 0.176 4.0 -0.25 7.0 11.0 CTNNB1 0.023 0.023 -9999.0 0.0 -0.403 1.0 1.0 ABI1/Sra1/Nap1 0.041 0.044 -9999.0 0.0 -0.238 8.0 8.0 AQP5 -0.051 0.157 -9999.0 0.0 -0.425 52.0 52.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.01 0.028 0.175 2.0 -0.195 5.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.061 0.175 4.0 -0.209 28.0 32.0 EGF -0.011 0.102 -9999.0 0.0 -0.403 21.0 21.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.013 0.11 -9999.0 0.0 -0.439 21.0 21.0 cortical microtubule organization 0.043 0.037 -9999.0 0.0 -0.201 6.0 6.0 GO:0000145 -0.01 0.027 0.163 2.0 -0.186 5.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.048 0.039 -9999.0 0.0 -0.203 6.0 6.0 MLLT4 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.04 -9999.0 0.0 -0.208 13.0 13.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.054 -9999.0 0.0 -0.218 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.028 0.172 3.0 -9999.0 0.0 3.0 PVRL2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.008 0.032 0.176 4.0 -0.197 5.0 9.0 ARF6/GTP 0.045 0.054 -9999.0 0.0 -0.204 11.0 11.0 CDH1 0.017 0.05 -9999.0 0.0 -0.403 5.0 5.0 EGFR/EGFR/EGF/EGF 0.017 0.076 -9999.0 0.0 -0.205 34.0 34.0 RhoA/GDP 0.044 0.035 -9999.0 0.0 -0.196 5.0 5.0 actin cytoskeleton organization -0.012 0.039 0.165 3.0 -0.265 5.0 8.0 IGF-1R heterotetramer -0.005 0.108 -9999.0 0.0 -0.403 25.0 25.0 GIT1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.005 0.109 -9999.0 0.0 -0.403 25.0 25.0 IGF1 -0.021 0.124 -9999.0 0.0 -0.403 33.0 33.0 DIAPH1 0.011 0.129 -9999.0 0.0 -0.541 12.0 12.0 Wnt receptor signaling pathway -0.043 0.037 0.201 6.0 -9999.0 0.0 6.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.019 0.04 -9999.0 0.0 -0.208 13.0 13.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.012 0.04 0.166 3.0 -0.27 5.0 8.0 EFNA1 0.014 0.055 -9999.0 0.0 -0.403 6.0 6.0 LPP -0.01 0.03 0.169 3.0 -9999.0 0.0 3.0 Ephrin A1/EPHA2 0.023 0.056 -9999.0 0.0 -0.215 15.0 15.0 SEC6/SEC8 -0.016 0.023 -9999.0 0.0 -0.187 5.0 5.0 MGAT3 -0.023 0.061 0.176 4.0 -0.212 28.0 32.0 HGF/MET 0.012 0.088 -9999.0 0.0 -0.217 40.0 40.0 HGF -0.004 0.099 -9999.0 0.0 -0.403 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.038 -9999.0 0.0 -0.236 7.0 7.0 actin cable formation 0.046 0.111 0.236 66.0 -0.242 2.0 68.0 KIAA1543 -0.009 0.037 0.165 5.0 -0.218 6.0 11.0 KIFC3 -0.012 0.036 0.176 4.0 -0.198 8.0 12.0 NCK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.009 0.032 0.176 4.0 -0.197 5.0 9.0 NCK1/GIT1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.043 0.037 -9999.0 0.0 -0.201 6.0 6.0 EXOC4 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.008 0.034 0.176 5.0 -0.197 5.0 10.0 PIP5K1C -0.01 0.029 0.176 2.0 -0.197 5.0 7.0 LIMA1 0.024 0.023 -9999.0 0.0 -0.403 1.0 1.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.022 0.095 0.335 12.0 -0.306 1.0 13.0 adherens junction assembly -0.039 0.14 0.214 1.0 -0.508 24.0 25.0 IGF-1R heterotetramer/IGF1 0.003 0.101 -9999.0 0.0 -0.229 51.0 51.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.006 0.107 -9999.0 0.0 -0.403 24.0 24.0 PLEKHA7 -0.009 0.039 0.176 5.0 -0.228 6.0 11.0 mol:GTP 0.039 0.053 -9999.0 0.0 -0.217 11.0 11.0 establishment of epithelial cell apical/basal polarity 0.002 0.071 0.377 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization 0.016 0.038 -9999.0 0.0 -0.234 7.0 7.0 regulation of cell-cell adhesion -0.012 0.039 0.165 3.0 -0.265 5.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.038 -9999.0 0.0 -0.236 7.0 7.0