Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	43.0	350.0	8.0	-0.279	0.148	1000.0	-1000.0	-0.018	-1000.0
TCGA08_p53	33.0	231.0	7.0	-0.213	0.108	1000.0	-1000.0	-0.01	-1000.0
Syndecan-1-mediated signaling events	24.0	821.0	34.0	-0.239	0.012	1000.0	-1000.0	-0.043	-1000.0
IL23-mediated signaling events	22.0	1375.0	60.0	-0.618	0.012	1000.0	-1000.0	-0.136	-1000.0
Wnt signaling	19.0	137.0	7.0	-0.145	0.007	1000.0	-1000.0	-0.026	-1000.0
IL4-mediated signaling events	18.0	1644.0	91.0	-0.662	0.586	1000.0	-1000.0	-0.162	-1000.0
Signaling events mediated by the Hedgehog family	16.0	851.0	52.0	-0.162	0.156	1000.0	-1000.0	-0.052	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1444.0	93.0	-0.195	0.096	1000.0	-1000.0	-0.07	-1000.0
IL12-mediated signaling events	14.0	1293.0	87.0	-0.344	0.077	1000.0	-1000.0	-0.128	-1000.0
BMP receptor signaling	13.0	1062.0	81.0	-0.276	0.031	1000.0	-1000.0	-0.083	-1000.0
amb2 Integrin signaling	13.0	1074.0	82.0	-0.178	0.015	1000.0	-1000.0	-0.078	-1000.0
Glucocorticoid receptor regulatory network	13.0	1504.0	114.0	-0.641	0.353	1000.0	-1000.0	-0.067	-1000.0
Syndecan-4-mediated signaling events	13.0	925.0	67.0	-0.251	0.03	1000.0	-1000.0	-0.089	-1000.0
Noncanonical Wnt signaling pathway	12.0	329.0	26.0	-0.145	0.012	1000.0	-1000.0	-0.058	-1000.0
HIF-1-alpha transcription factor network	12.0	950.0	76.0	-0.413	0.02	1000.0	-1000.0	-0.123	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	12.0	846.0	68.0	-0.319	0.114	1000.0	-1000.0	-0.118	-1000.0
Glypican 1 network	11.0	529.0	48.0	-0.218	0.016	1000.0	-1000.0	-0.036	-1000.0
Reelin signaling pathway	11.0	642.0	56.0	-0.162	0.03	1000.0	-1000.0	-0.067	-1000.0
Signaling mediated by p38-alpha and p38-beta	11.0	524.0	44.0	-0.141	0.012	1000.0	-1000.0	-0.054	-1000.0
Glypican 2 network	11.0	45.0	4.0	-0.06	-0.056	1000.0	-1000.0	-0.022	-1000.0
BCR signaling pathway	11.0	1116.0	99.0	-0.222	0.014	1000.0	-1000.0	-0.082	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	832.0	82.0	-0.114	0.012	1000.0	-1000.0	-0.074	-1000.0
Caspase cascade in apoptosis	9.0	691.0	74.0	-0.124	0.063	1000.0	-1000.0	-0.033	-1000.0
Ephrin A  reverse signaling	9.0	63.0	7.0	-0.027	-0.0	1000.0	-1000.0	-0.015	-1000.0
Thromboxane A2 receptor signaling	9.0	996.0	105.0	-0.1	0.029	1000.0	-1000.0	-0.059	-1000.0
p75(NTR)-mediated signaling	9.0	1235.0	125.0	-0.188	0.037	1000.0	-1000.0	-0.087	-1000.0
Nongenotropic Androgen signaling	9.0	470.0	52.0	-0.169	0.021	1000.0	-1000.0	-0.058	-1000.0
Class IB PI3K non-lipid kinase events	9.0	27.0	3.0	-0.039	-1000.0	1000.0	-1000.0	-0.009	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	847.0	97.0	-0.118	0.027	1000.0	-1000.0	-0.075	-1000.0
Endothelins	8.0	804.0	96.0	-0.147	0.015	1000.0	-1000.0	-0.086	-1000.0
EPHB forward signaling	8.0	692.0	85.0	-0.09	0.078	1000.0	-1000.0	-0.082	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	270.0	31.0	-0.215	0.012	1000.0	-1000.0	-0.084	-1000.0
IL27-mediated signaling events	8.0	411.0	51.0	-0.322	0.055	1000.0	-1000.0	-0.077	-1000.0
IGF1 pathway	8.0	466.0	57.0	-0.117	0.021	1000.0	-1000.0	-0.09	-1000.0
Visual signal transduction: Rods	8.0	442.0	52.0	-0.196	0.012	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	8.0	677.0	78.0	-0.11	0.056	1000.0	-1000.0	-0.07	-1000.0
ErbB2/ErbB3 signaling events	7.0	456.0	65.0	-0.128	0.026	1000.0	-1000.0	-0.06	-1000.0
Coregulation of Androgen receptor activity	7.0	567.0	76.0	-0.329	0.022	1000.0	-1000.0	-0.034	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	7.0	262.0	34.0	-0.054	0.012	1000.0	-1000.0	-0.048	-1000.0
ErbB4 signaling events	7.0	511.0	69.0	-0.201	0.049	1000.0	-1000.0	-0.079	-1000.0
Osteopontin-mediated events	7.0	273.0	38.0	-0.086	0.012	1000.0	-1000.0	-0.093	-1000.0
JNK signaling in the CD4+ TCR pathway	7.0	122.0	17.0	-0.064	0.012	1000.0	-1000.0	-0.035	-1000.0
IL1-mediated signaling events	7.0	456.0	62.0	-0.181	0.058	1000.0	-1000.0	-0.089	-1000.0
S1P5 pathway	7.0	124.0	17.0	-0.087	0.071	1000.0	-1000.0	-0.027	-1000.0
Integrins in angiogenesis	7.0	599.0	84.0	-0.173	0.019	1000.0	-1000.0	-0.083	-1000.0
LPA receptor mediated events	7.0	813.0	102.0	-0.148	0.023	1000.0	-1000.0	-0.077	-1000.0
Rapid glucocorticoid signaling	7.0	148.0	20.0	-0.179	0.012	1000.0	-1000.0	-0.022	-1000.0
Syndecan-2-mediated signaling events	6.0	480.0	69.0	-0.142	0.034	1000.0	-1000.0	-0.03	-1000.0
Ephrin B reverse signaling	6.0	309.0	48.0	-0.073	0.043	1000.0	-1000.0	-0.063	-1000.0
IL6-mediated signaling events	6.0	498.0	75.0	-0.124	0.057	1000.0	-1000.0	-0.072	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	467.0	74.0	-0.111	0.043	1000.0	-1000.0	-0.082	-1000.0
EGFR-dependent Endothelin signaling events	6.0	133.0	21.0	-0.083	0.018	1000.0	-1000.0	-0.06	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	833.0	120.0	-0.179	0.134	1000.0	-1000.0	-0.065	-1000.0
LPA4-mediated signaling events	5.0	62.0	12.0	-0.071	0.018	1000.0	-1000.0	-0.023	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	145.0	28.0	-0.087	0.016	1000.0	-1000.0	-0.032	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	272.0	54.0	-0.162	0.025	1000.0	-1000.0	-0.084	-1000.0
Arf6 signaling events	5.0	369.0	62.0	-0.094	0.012	1000.0	-1000.0	-0.057	-1000.0
Nectin adhesion pathway	5.0	374.0	63.0	-0.069	0.022	1000.0	-1000.0	-0.063	-1000.0
S1P1 pathway	5.0	180.0	36.0	-0.088	0.012	1000.0	-1000.0	-0.054	-1000.0
Syndecan-3-mediated signaling events	5.0	181.0	35.0	-0.199	0.037	1000.0	-1000.0	-0.041	-1000.0
Plasma membrane estrogen receptor signaling	5.0	439.0	86.0	-0.111	0.024	1000.0	-1000.0	-0.075	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	515.0	88.0	-0.112	0.035	1000.0	-1000.0	-0.091	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	5.0	178.0	33.0	-0.287	0.037	1000.0	-1000.0	-0.045	-1000.0
S1P4 pathway	5.0	139.0	25.0	-0.087	0.016	1000.0	-1000.0	-0.044	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	97.0	17.0	-0.063	0.023	1000.0	-1000.0	-0.036	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	665.0	136.0	-0.233	0.063	1000.0	-1000.0	-0.062	-1000.0
Visual signal transduction: Cones	4.0	179.0	38.0	-0.053	0.012	1000.0	-1000.0	-0.053	-1000.0
Cellular roles of Anthrax toxin	4.0	192.0	39.0	-0.068	0.013	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PTP1B	4.0	374.0	76.0	-0.106	0.016	1000.0	-1000.0	-0.074	-1000.0
FOXA2 and FOXA3 transcription factor networks	4.0	226.0	46.0	-0.302	0.018	1000.0	-1000.0	-0.093	-1000.0
PDGFR-alpha signaling pathway	4.0	199.0	44.0	-0.052	0.02	1000.0	-1000.0	-0.056	-1000.0
IFN-gamma pathway	4.0	294.0	68.0	-0.077	0.022	1000.0	-1000.0	-0.083	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	247.0	52.0	-0.16	0.039	1000.0	-1000.0	-0.046	-1000.0
FAS signaling pathway (CD95)	4.0	222.0	47.0	-0.191	0.014	1000.0	-1000.0	-0.044	-1000.0
Effects of Botulinum toxin	4.0	127.0	26.0	-0.071	0.012	1000.0	-1000.0	-0.06	-1000.0
IL2 signaling events mediated by STAT5	4.0	100.0	22.0	-0.102	0.013	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	4.0	183.0	43.0	-0.05	0.025	1000.0	-1000.0	-0.064	-1000.0
FOXM1 transcription factor network	4.0	251.0	51.0	-0.291	0.112	1000.0	-1000.0	-0.173	-1000.0
E-cadherin signaling events	4.0	24.0	5.0	-0.027	0.012	1000.0	-1000.0	-0.018	-1000.0
Regulation of Androgen receptor activity	4.0	329.0	70.0	-0.368	0.021	1000.0	-1000.0	-0.069	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	17.0	5.0	-0.014	0.005	1000.0	-1000.0	-0.027	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	199.0	65.0	-0.098	0.048	1000.0	-1000.0	-0.053	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	208.0	61.0	-0.116	0.035	1000.0	-1000.0	-0.081	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	53.0	15.0	-0.024	0.019	1000.0	-1000.0	-0.025	-1000.0
IL2 signaling events mediated by PI3K	3.0	231.0	58.0	-0.089	0.03	1000.0	-1000.0	-0.08	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	165.0	45.0	-0.078	0.029	1000.0	-1000.0	-0.076	-1000.0
Canonical Wnt signaling pathway	3.0	201.0	51.0	-0.116	0.048	1000.0	-1000.0	-0.052	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	271.0	76.0	-0.053	0.03	1000.0	-1000.0	-0.074	-1000.0
S1P3 pathway	3.0	148.0	42.0	-0.086	0.02	1000.0	-1000.0	-0.032	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	233.0	85.0	-0.092	0.02	1000.0	-1000.0	-0.072	-1000.0
Ceramide signaling pathway	2.0	173.0	76.0	-0.111	0.022	1000.0	-1000.0	-0.043	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	92.0	37.0	-0.032	0.021	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by HDAC Class III	2.0	94.0	40.0	-0.102	0.019	1000.0	-1000.0	-0.03	-1000.0
TRAIL signaling pathway	2.0	132.0	48.0	-0.019	0.035	1000.0	-1000.0	-0.062	-1000.0
HIF-2-alpha transcription factor network	2.0	119.0	43.0	-0.056	0.063	1000.0	-1000.0	-0.078	-1000.0
Regulation of p38-alpha and p38-beta	2.0	161.0	54.0	-0.096	0.03	1000.0	-1000.0	-0.058	-1000.0
TCGA08_rtk_signaling	2.0	66.0	26.0	-0.057	0.033	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events	2.0	196.0	73.0	-0.096	0.028	1000.0	-1000.0	-0.057	-1000.0
Regulation of Telomerase	2.0	297.0	102.0	-0.146	0.04	1000.0	-1000.0	-0.098	-1000.0
Insulin Pathway	2.0	160.0	74.0	-0.065	0.034	1000.0	-1000.0	-0.078	-1000.0
Aurora B signaling	2.0	192.0	67.0	-0.163	0.023	1000.0	-1000.0	-0.061	-1000.0
Canonical NF-kappaB pathway	1.0	47.0	39.0	-0.048	0.068	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by HDAC Class II	1.0	116.0	75.0	-0.056	0.032	1000.0	-1000.0	-0.043	-1000.0
BARD1 signaling events	1.0	103.0	57.0	-0.013	0.057	1000.0	-1000.0	-0.059	-1000.0
Arf6 downstream pathway	1.0	44.0	43.0	-0.02	0.023	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	1.0	13.0	7.0	-0.01	-0.0	1000.0	-1000.0	-0.033	-1000.0
EPO signaling pathway	1.0	68.0	55.0	-0.025	0.047	1000.0	-1000.0	-0.086	-1000.0
ceramide signaling pathway	1.0	67.0	49.0	-0.048	0.027	1000.0	-1000.0	-0.044	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	156.0	83.0	-0.094	0.044	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by HDAC Class I	1.0	122.0	104.0	-0.072	0.051	1000.0	-1000.0	-0.063	-1000.0
Retinoic acid receptors-mediated signaling	1.0	101.0	58.0	-0.043	0.037	1000.0	-1000.0	-0.067	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	54.0	36.0	-0.032	0.028	1000.0	-1000.0	-0.067	-1000.0
Atypical NF-kappaB pathway	1.0	34.0	31.0	-0.023	0.028	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	175.0	125.0	-0.024	0.067	1000.0	-1000.0	-0.085	-1000.0
Arf6 trafficking events	1.0	83.0	71.0	-0.064	0.04	1000.0	-1000.0	-0.064	-1000.0
VEGFR1 specific signals	1.0	70.0	56.0	-0.024	0.046	1000.0	-1000.0	-0.049	-1000.0
PDGFR-beta signaling pathway	1.0	181.0	97.0	-0.055	0.052	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by PRL	1.0	66.0	34.0	-0.086	0.033	1000.0	-1000.0	-0.032	-1000.0
p38 MAPK signaling pathway	1.0	62.0	44.0	-0.067	0.024	1000.0	-1000.0	-0.066	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.012	0.043	1000.0	-1000.0	-0.052	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.012	0.021	1000.0	-1000.0	-0.016	-1000.0
Circadian rhythm pathway	0.0	14.0	22.0	-0.019	0.04	1000.0	-1000.0	-0.042	-1000.0
Aurora A signaling	0.0	58.0	60.0	-0.03	0.032	1000.0	-1000.0	-0.041	-1000.0
PLK1 signaling events	0.0	37.0	85.0	-0.006	0.034	1000.0	-1000.0	-0.044	-1000.0
Insulin-mediated glucose transport	0.0	31.0	32.0	-0.031	0.029	1000.0	-1000.0	-0.06	-1000.0
mTOR signaling pathway	0.0	36.0	53.0	-0.008	0.031	1000.0	-1000.0	-0.053	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	36.0	68.0	-0.032	0.045	1000.0	-1000.0	-0.047	-1000.0
FoxO family signaling	0.0	35.0	64.0	-0.068	0.13	1000.0	-1000.0	-0.06	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	9.0	27.0	-0.007	0.031	1000.0	-1000.0	-0.052	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.006	0.027	1000.0	-1000.0	-0.032	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.037	1000.0	-1000.0	-0.036	-1000.0
Total	777	45463	7203	-16.5745442627	-994.599700042	131000	-131000	-7.91750541411	-131000