E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.02 0.121 -9999.0 0.0 -0.423 8.0 8.0 KLHL20 -0.009 0.111 0.193 4.0 -0.244 14.0 18.0 CYFIP2 0.015 0.08 -9999.0 0.0 -0.482 3.0 3.0 Rac1/GDP 0.001 0.106 0.26 4.0 -0.28 7.0 11.0 ENAH -0.02 0.125 -9999.0 0.0 -0.413 9.0 9.0 AP1M1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.006 0.062 -9999.0 0.0 -0.217 6.0 6.0 ABI1/Sra1/Nap1 -0.031 0.062 -9999.0 0.0 -0.173 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.104 -9999.0 0.0 -0.297 10.0 10.0 RAPGEF1 -0.01 0.123 0.286 2.0 -0.382 9.0 11.0 CTNND1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.013 0.134 -9999.0 0.0 -0.423 10.0 10.0 CRK -0.019 0.116 -9999.0 0.0 -0.409 9.0 9.0 E-cadherin/gamma catenin/alpha catenin 0.025 0.113 -9999.0 0.0 -0.41 7.0 7.0 alphaE/beta7 Integrin 0.024 0.07 -9999.0 0.0 -0.345 4.0 4.0 IQGAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.021 0.125 -9999.0 0.0 -0.413 9.0 9.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.036 -9999.0 0.0 -0.164 5.0 5.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.041 0.053 -9999.0 0.0 -0.273 3.0 3.0 PI3K -0.026 0.046 -9999.0 0.0 -0.209 5.0 5.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.01 0.124 -9999.0 0.0 -0.47 7.0 7.0 TIAM1 0.015 0.079 -9999.0 0.0 -0.482 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.038 0.078 -9999.0 0.0 -0.26 7.0 7.0 AKT1 -0.006 0.047 0.149 2.0 -9999.0 0.0 2.0 PIK3R1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.002 0.119 -9999.0 0.0 -0.482 7.0 7.0 RhoA/GDP 0.001 0.103 0.271 3.0 -0.278 7.0 10.0 actin cytoskeleton organization -0.004 0.084 0.16 4.0 -0.179 13.0 17.0 CDC42/GDP 0.003 0.107 0.26 4.0 -0.278 7.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.003 0.088 -9999.0 0.0 -0.338 7.0 7.0 ITGB7 0.011 0.091 -9999.0 0.0 -0.482 4.0 4.0 RAC1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.042 0.083 -9999.0 0.0 -0.277 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.026 0.072 -9999.0 0.0 -0.256 7.0 7.0 mol:GDP -0.012 0.113 0.265 4.0 -0.318 7.0 11.0 CDC42/GTP/IQGAP1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.015 0.079 -9999.0 0.0 -0.482 3.0 3.0 p120 catenin/RhoA/GDP 0.005 0.104 0.275 3.0 -0.286 7.0 10.0 RAC1/GTP/IQGAP1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.006 0.075 0.128 4.0 -0.197 10.0 14.0 NME1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.017 0.125 -9999.0 0.0 -0.431 9.0 9.0 regulation of cell-cell adhesion 0.001 0.052 -9999.0 0.0 -0.19 7.0 7.0 WASF2 -0.003 0.046 0.095 2.0 -0.116 5.0 7.0 Rap1/GTP 0.009 0.075 0.262 2.0 -0.236 7.0 9.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.031 0.128 -9999.0 0.0 -0.354 10.0 10.0 CCND1 -0.009 0.091 0.146 4.0 -0.235 11.0 15.0 VAV2 -0.062 0.23 -9999.0 0.0 -0.533 20.0 20.0 RAP1/GDP 0.011 0.091 0.271 3.0 -0.245 6.0 9.0 adherens junction assembly -0.016 0.121 -9999.0 0.0 -0.418 9.0 9.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.015 0.119 -9999.0 0.0 -0.342 10.0 10.0 E-cadherin/beta catenin -0.01 0.085 -9999.0 0.0 -0.351 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.023 0.129 -9999.0 0.0 -0.432 9.0 9.0 PIK3CA 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.06 0.155 -9999.0 0.0 -0.407 15.0 15.0 E-cadherin/beta catenin/alpha catenin 0.029 0.084 -9999.0 0.0 -0.301 7.0 7.0 ITGAE 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.014 0.137 -9999.0 0.0 -0.432 10.0 10.0