Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.014 0.091 0.361 6.0 -9999.0 0.0 6.0 KIRREL -0.001 0.114 -9999.0 0.0 -0.489 6.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.014 0.091 -9999.0 0.0 -0.361 6.0 6.0 PLCG1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.03 0.1 -9999.0 0.0 -0.271 11.0 11.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.003 0.076 -9999.0 0.0 -0.255 9.0 9.0 FYN -0.005 0.107 0.295 5.0 -0.254 11.0 16.0 mol:Ca2+ 0.026 0.095 -9999.0 0.0 -0.269 10.0 10.0 mol:DAG 0.027 0.096 -9999.0 0.0 -0.27 10.0 10.0 NPHS2 -0.019 0.103 -9999.0 0.0 -0.49 5.0 5.0 mol:IP3 0.027 0.096 -9999.0 0.0 -0.27 10.0 10.0 regulation of endocytosis 0.018 0.085 -9999.0 0.0 -0.235 11.0 11.0 Nephrin/NEPH1/podocin/Cholesterol 0.016 0.093 -9999.0 0.0 -0.267 11.0 11.0 establishment of cell polarity 0.014 0.091 -9999.0 0.0 -0.361 6.0 6.0 Nephrin/NEPH1/podocin/NCK1-2 0.04 0.095 -9999.0 0.0 -0.249 10.0 10.0 Nephrin/NEPH1/beta Arrestin2 0.02 0.086 -9999.0 0.0 -0.237 11.0 11.0 NPHS1 0.002 0.038 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin 0.016 0.089 -9999.0 0.0 -0.256 11.0 11.0 TJP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.028 0.097 -9999.0 0.0 -0.271 10.0 10.0 CD2AP 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.031 0.097 -9999.0 0.0 -0.271 10.0 10.0 GRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.009 0.106 0.234 9.0 -0.245 11.0 20.0 cytoskeleton organization -0.018 0.079 0.192 2.0 -0.28 8.0 10.0 Nephrin/NEPH1 0.015 0.065 -9999.0 0.0 -0.251 6.0 6.0 Nephrin/NEPH1/ZO-1 0.029 0.079 -9999.0 0.0 -0.287 6.0 6.0