Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.004 0.062 -9999.0 0.0 -0.225 8.0 8.0 epithelial cell differentiation 0.034 0.075 -9999.0 0.0 -0.258 7.0 7.0 CYFIP2 0.015 0.08 -9999.0 0.0 -0.482 3.0 3.0 ENAH 0.002 0.111 0.282 9.0 -0.379 2.0 11.0 EGFR -0.005 0.119 -9999.0 0.0 -0.482 7.0 7.0 EPHA2 0.007 0.102 -9999.0 0.0 -0.482 5.0 5.0 MYO6 -0.013 0.084 0.349 1.0 -0.25 7.0 8.0 CTNNB1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.058 -9999.0 0.0 -0.294 3.0 3.0 AQP5 0.001 0.07 0.24 1.0 -0.283 1.0 2.0 CTNND1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.015 0.076 0.172 9.0 -0.247 7.0 16.0 regulation of calcium-dependent cell-cell adhesion -0.017 0.097 0.193 10.0 -0.248 12.0 22.0 EGF 0.025 0.07 -9999.0 0.0 -0.482 2.0 2.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.08 0.207 -9999.0 0.0 -0.467 24.0 24.0 cortical microtubule organization 0.034 0.075 -9999.0 0.0 -0.258 7.0 7.0 GO:0000145 -0.016 0.071 0.158 9.0 -0.236 7.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.038 0.078 -9999.0 0.0 -0.26 7.0 7.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.041 0.079 -9999.0 0.0 -0.304 8.0 8.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.048 0.074 -9999.0 0.0 -0.357 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.008 0.073 0.342 1.0 -0.238 1.0 2.0 PVRL2 0.019 0.065 -9999.0 0.0 -0.482 2.0 2.0 ZYX -0.013 0.083 0.349 1.0 -0.248 7.0 8.0 ARF6/GTP 0.053 0.073 -9999.0 0.0 -0.336 3.0 3.0 CDH1 -0.002 0.119 -9999.0 0.0 -0.482 7.0 7.0 EGFR/EGFR/EGF/EGF 0.009 0.102 -9999.0 0.0 -0.268 13.0 13.0 RhoA/GDP 0.035 0.074 -9999.0 0.0 -0.248 7.0 7.0 actin cytoskeleton organization -0.015 0.079 0.331 1.0 -0.248 7.0 8.0 IGF-1R heterotetramer 0.006 0.101 -9999.0 0.0 -0.482 5.0 5.0 GIT1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.006 0.102 -9999.0 0.0 -0.482 5.0 5.0 IGF1 -0.011 0.15 -9999.0 0.0 -0.482 11.0 11.0 DIAPH1 -0.004 0.181 -9999.0 0.0 -0.59 8.0 8.0 Wnt receptor signaling pathway -0.034 0.075 0.258 7.0 -9999.0 0.0 7.0 RHOA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.041 0.079 -9999.0 0.0 -0.317 7.0 7.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.016 0.08 0.333 1.0 -0.253 7.0 8.0 EFNA1 0.017 0.065 -9999.0 0.0 -0.482 2.0 2.0 LPP -0.019 0.075 0.339 1.0 -0.243 7.0 8.0 Ephrin A1/EPHA2 0.014 0.105 -9999.0 0.0 -0.317 9.0 9.0 SEC6/SEC8 -0.034 0.053 -9999.0 0.0 -0.238 7.0 7.0 MGAT3 -0.017 0.099 0.194 10.0 -0.252 12.0 22.0 HGF/MET 0.009 0.099 -9999.0 0.0 -0.244 15.0 15.0 HGF -0.01 0.143 -9999.0 0.0 -0.482 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.004 0.062 -9999.0 0.0 -0.226 8.0 8.0 actin cable formation 0.023 0.116 0.297 10.0 -0.289 3.0 13.0 KIAA1543 -0.026 0.11 0.336 1.0 -0.326 10.0 11.0 KIFC3 -0.016 0.084 0.349 1.0 -0.249 8.0 9.0 NCK1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.084 0.349 1.0 -0.25 7.0 8.0 NCK1/GIT1 0.036 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.034 0.075 -9999.0 0.0 -0.258 7.0 7.0 EXOC4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.008 0.078 0.349 1.0 -0.25 5.0 6.0 PIP5K1C -0.016 0.077 0.173 9.0 -0.25 7.0 16.0 LIMA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.003 0.126 0.304 9.0 -0.451 2.0 11.0 adherens junction assembly -0.034 0.145 0.265 1.0 -0.451 9.0 10.0 IGF-1R heterotetramer/IGF1 -0.007 0.121 -9999.0 0.0 -0.254 22.0 22.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.051 -9999.0 0.0 -0.351 2.0 2.0 MET 0.023 0.046 -9999.0 0.0 -0.482 1.0 1.0 PLEKHA7 -0.026 0.116 0.191 10.0 -0.342 10.0 20.0 mol:GTP 0.046 0.073 -9999.0 0.0 -0.354 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.009 0.121 0.366 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization 0.004 0.062 -9999.0 0.0 -0.225 8.0 8.0 regulation of cell-cell adhesion -0.015 0.079 0.331 1.0 -0.248 7.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.004 0.062 -9999.0 0.0 -0.226 8.0 8.0