E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.02 0.113 -9999.0 0.0 -0.411 36.0 36.0 KLHL20 0.016 0.069 0.223 12.0 -0.221 15.0 27.0 CYFIP2 0.029 0.044 0.265 21.0 -0.6 1.0 22.0 Rac1/GDP -0.0 0.087 0.26 9.0 -0.309 16.0 25.0 ENAH -0.017 0.106 -9999.0 0.0 -0.398 33.0 33.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.008 0.049 -9999.0 0.0 -0.253 14.0 14.0 ABI1/Sra1/Nap1 -0.013 0.033 -9999.0 0.0 -0.157 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.068 -9999.0 0.0 -0.356 16.0 16.0 RAPGEF1 -0.019 0.108 0.263 1.0 -0.399 26.0 27.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.125 -9999.0 0.0 -0.414 43.0 43.0 CRK -0.017 0.103 -9999.0 0.0 -0.419 29.0 29.0 E-cadherin/gamma catenin/alpha catenin 0.032 0.063 -9999.0 0.0 -0.387 14.0 14.0 alphaE/beta7 Integrin 0.035 0.034 -9999.0 0.0 -0.447 2.0 2.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.041 0.023 -9999.0 0.0 -0.355 1.0 1.0 DLG1 -0.024 0.119 -9999.0 0.0 -0.407 41.0 41.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.028 -9999.0 0.0 -0.189 13.0 13.0 MLLT4 0.022 0.023 -9999.0 0.0 -0.6 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.043 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.042 -9999.0 0.0 -0.243 13.0 13.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.068 -9999.0 0.0 -0.343 24.0 24.0 TIAM1 0.025 0.015 0.265 3.0 -9999.0 0.0 3.0 E-cadherin(dimer)/Ca2+ 0.04 0.058 -9999.0 0.0 -0.336 14.0 14.0 AKT1 -0.007 0.034 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.011 0.081 -9999.0 0.0 -0.6 14.0 14.0 RhoA/GDP 0.0 0.087 0.259 9.0 -0.311 15.0 24.0 actin cytoskeleton organization 0.015 0.056 0.186 19.0 -0.163 13.0 32.0 CDC42/GDP 0.0 0.086 0.259 9.0 -0.311 15.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.007 0.045 -9999.0 0.0 -0.275 16.0 16.0 ITGB7 0.027 0.045 0.265 15.0 -0.6 2.0 17.0 RAC1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.044 0.062 -9999.0 0.0 -0.356 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.029 0.054 -9999.0 0.0 -0.333 14.0 14.0 mol:GDP -0.014 0.094 0.266 9.0 -0.354 17.0 26.0 CDC42/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.004 0.089 0.265 5.0 -0.322 14.0 19.0 RAC1/GTP/IQGAP1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.05 0.183 34.0 -0.25 3.0 37.0 NME1 0.024 0.024 0.265 7.0 -9999.0 0.0 7.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.118 -9999.0 0.0 -0.414 38.0 38.0 regulation of cell-cell adhesion 0.003 0.041 -9999.0 0.0 -0.223 14.0 14.0 WASF2 0.007 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.012 0.059 0.246 1.0 -0.28 14.0 15.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.069 -9999.0 0.0 -0.339 16.0 16.0 CCND1 0.015 0.058 0.211 31.0 -0.317 3.0 34.0 VAV2 -0.021 0.155 -9999.0 0.0 -0.546 35.0 35.0 RAP1/GDP 0.005 0.072 0.265 3.0 -0.288 14.0 17.0 adherens junction assembly -0.022 0.114 -9999.0 0.0 -0.401 38.0 38.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.039 0.065 -9999.0 0.0 -0.328 16.0 16.0 E-cadherin/beta catenin -0.0 0.062 -9999.0 0.0 -0.348 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.119 -9999.0 0.0 -0.407 42.0 42.0 PIK3CA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.006 0.095 0.273 27.0 -0.346 21.0 48.0 E-cadherin/beta catenin/alpha catenin 0.033 0.062 -9999.0 0.0 -0.387 14.0 14.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.127 -9999.0 0.0 -0.423 43.0 43.0