Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.023 0.13 0.442 48.0 -0.234 7.0 55.0 KIRREL -0.013 0.149 -9999.0 0.0 -0.602 49.0 49.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.023 0.13 0.235 7.0 -0.442 48.0 55.0 PLCG1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.042 0.11 0.29 4.0 -0.342 46.0 50.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.013 0.08 0.241 1.0 -0.292 39.0 40.0 FYN 0.022 0.125 0.274 93.0 -0.327 45.0 138.0 mol:Ca2+ 0.038 0.107 0.28 4.0 -0.339 44.0 48.0 mol:DAG 0.039 0.108 0.285 4.0 -0.34 44.0 48.0 NPHS2 0.017 0.031 0.27 5.0 -9999.0 0.0 5.0 mol:IP3 0.039 0.108 0.285 4.0 -0.34 44.0 48.0 regulation of endocytosis 0.029 0.097 0.246 5.0 -0.31 45.0 50.0 Nephrin/NEPH1/podocin/Cholesterol 0.031 0.105 0.255 9.0 -0.339 46.0 55.0 establishment of cell polarity 0.023 0.13 0.234 7.0 -0.442 48.0 55.0 Nephrin/NEPH1/podocin/NCK1-2 0.052 0.106 0.325 1.0 -0.316 44.0 45.0 Nephrin/NEPH1/beta Arrestin2 0.033 0.1 0.255 5.0 -0.313 45.0 50.0 NPHS1 0.061 0.091 0.267 126.0 -9999.0 0.0 126.0 Nephrin/NEPH1/podocin 0.032 0.103 0.309 4.0 -0.328 45.0 49.0 TJP1 0.023 0.022 -9999.0 0.0 -0.6 1.0 1.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.041 0.109 0.29 4.0 -0.342 44.0 48.0 CD2AP 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.039 0.107 0.29 4.0 -0.341 43.0 47.0 GRB2 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.021 0.132 0.29 85.0 -0.329 50.0 135.0 cytoskeleton organization 0.01 0.1 0.264 15.0 -0.339 41.0 56.0 Nephrin/NEPH1 0.023 0.097 0.203 2.0 -0.319 47.0 49.0 Nephrin/NEPH1/ZO-1 0.033 0.114 -9999.0 0.0 -0.371 47.0 47.0