Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.045 -9999.0 0.0 -0.27 16.0 16.0 epithelial cell differentiation 0.036 0.056 -9999.0 0.0 -0.333 14.0 14.0 CYFIP2 0.029 0.044 0.265 21.0 -0.6 1.0 22.0 ENAH -0.004 0.06 0.274 8.0 -9999.0 0.0 8.0 EGFR -0.186 0.294 -9999.0 0.0 -0.6 277.0 277.0 EPHA2 0.02 0.049 -9999.0 0.0 -0.6 5.0 5.0 MYO6 -0.013 0.052 -9999.0 0.0 -0.323 15.0 15.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.032 -9999.0 0.0 -0.387 1.0 1.0 AQP5 -0.202 0.27 0.334 1.0 -0.516 340.0 341.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.05 -9999.0 0.0 -0.318 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.026 0.08 -9999.0 0.0 -0.323 48.0 48.0 EGF -0.09 0.242 0.265 2.0 -0.6 151.0 153.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.018 0.122 0.292 1.0 -0.482 42.0 43.0 cortical microtubule organization 0.036 0.056 -9999.0 0.0 -0.333 14.0 14.0 GO:0000145 -0.013 0.047 -9999.0 0.0 -0.303 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.04 0.058 -9999.0 0.0 -0.336 14.0 14.0 MLLT4 0.022 0.023 -9999.0 0.0 -0.6 1.0 1.0 ARF6/GDP -0.022 0.042 -9999.0 0.0 -0.294 16.0 16.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.042 -9999.0 0.0 -0.353 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.049 -9999.0 0.0 -0.305 14.0 14.0 PVRL2 0.024 0.009 0.265 1.0 -9999.0 0.0 1.0 ZYX -0.013 0.05 -9999.0 0.0 -0.321 14.0 14.0 ARF6/GTP 0.048 0.044 -9999.0 0.0 -0.331 5.0 5.0 CDH1 0.011 0.081 -9999.0 0.0 -0.6 14.0 14.0 EGFR/EGFR/EGF/EGF -0.147 0.205 -9999.0 0.0 -0.351 386.0 386.0 RhoA/GDP 0.037 0.055 -9999.0 0.0 -0.319 14.0 14.0 actin cytoskeleton organization -0.015 0.049 -9999.0 0.0 -0.313 15.0 15.0 IGF-1R heterotetramer 0.013 0.081 0.264 1.0 -0.599 14.0 15.0 GIT1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.081 0.265 1.0 -0.6 14.0 15.0 IGF1 -0.11 0.256 -9999.0 0.0 -0.6 177.0 177.0 DIAPH1 0.025 0.105 -9999.0 0.0 -0.587 6.0 6.0 Wnt receptor signaling pathway -0.036 0.056 0.333 14.0 -9999.0 0.0 14.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.022 0.042 -9999.0 0.0 -0.295 16.0 16.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.015 0.05 -9999.0 0.0 -0.32 15.0 15.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.015 0.05 -9999.0 0.0 -0.311 15.0 15.0 Ephrin A1/EPHA2 0.024 0.057 -9999.0 0.0 -0.314 17.0 17.0 SEC6/SEC8 -0.023 0.041 -9999.0 0.0 -0.303 15.0 15.0 MGAT3 -0.027 0.081 -9999.0 0.0 -0.328 48.0 48.0 HGF/MET -0.044 0.163 -9999.0 0.0 -0.343 176.0 176.0 HGF -0.011 0.143 -9999.0 0.0 -0.6 46.0 46.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.046 -9999.0 0.0 -0.272 16.0 16.0 actin cable formation 0.04 0.095 0.294 33.0 -0.286 2.0 35.0 KIAA1543 -0.013 0.051 -9999.0 0.0 -0.328 14.0 14.0 KIFC3 -0.014 0.048 -9999.0 0.0 -0.322 14.0 14.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.05 -9999.0 0.0 -0.322 14.0 14.0 NCK1/GIT1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.036 0.056 -9999.0 0.0 -0.333 14.0 14.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.05 -9999.0 0.0 -0.322 14.0 14.0 PIP5K1C -0.013 0.051 -9999.0 0.0 -0.322 14.0 14.0 LIMA1 0.024 0.022 -9999.0 0.0 -0.6 1.0 1.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.015 0.088 0.296 20.0 -9999.0 0.0 20.0 adherens junction assembly -0.025 0.105 0.276 2.0 -0.628 13.0 15.0 IGF-1R heterotetramer/IGF1 -0.047 0.155 -9999.0 0.0 -0.325 183.0 183.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.023 -9999.0 0.0 -0.28 3.0 3.0 MET -0.079 0.232 -9999.0 0.0 -0.6 136.0 136.0 PLEKHA7 -0.014 0.054 -9999.0 0.0 -0.344 14.0 14.0 mol:GTP 0.042 0.041 -9999.0 0.0 -0.351 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.009 0.065 0.349 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.011 0.045 -9999.0 0.0 -0.27 16.0 16.0 regulation of cell-cell adhesion -0.015 0.049 -9999.0 0.0 -0.313 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.046 -9999.0 0.0 -0.272 16.0 16.0