Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.054 0.255 -9999.0 0.0 -0.553 103.0 103.0 IHH 0.009 0.047 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.138 0.201 -9999.0 0.0 -0.428 170.0 170.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.137 0.2 0.425 170.0 -9999.0 0.0 170.0 SMO/beta Arrestin2 -0.003 0.16 -9999.0 0.0 -0.622 9.0 9.0 SMO -0.011 0.169 -9999.0 0.0 -0.592 12.0 12.0 AKT1 -0.014 0.165 -9999.0 0.0 -0.61 25.0 25.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.148 0.307 -9999.0 0.0 -0.723 117.0 117.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.167 -9999.0 0.0 -0.582 12.0 12.0 STIL 0.011 0.125 -9999.0 0.0 -0.385 10.0 10.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.001 0.124 -9999.0 0.0 -0.391 3.0 3.0 PIK3CA 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.153 0.466 -9999.0 0.0 -1.093 103.0 103.0 determination of left/right symmetry -0.011 0.167 -9999.0 0.0 -0.582 12.0 12.0 PIK3R1 -0.055 0.218 -9999.0 0.0 -0.723 51.0 51.0 skeletal system development -0.15 0.459 -9999.0 0.0 -1.074 103.0 103.0 IHH N/Hhip 0.023 0.024 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.001 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.167 -9999.0 0.0 -0.582 12.0 12.0 pancreas development 0.015 0.014 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.006 0.074 -9999.0 0.0 -0.723 5.0 5.0 PI3K -0.052 0.16 -9999.0 0.0 -0.54 51.0 51.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.218 0.344 -9999.0 0.0 -0.723 167.0 167.0 somite specification -0.011 0.167 -9999.0 0.0 -0.582 12.0 12.0 SHH Np/Cholesterol/PTCH1 0.008 0.119 -9999.0 0.0 -0.37 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.005 0.041 -9999.0 0.0 -0.419 5.0 5.0 SHH Np/Cholesterol/Megalin -0.122 0.195 -9999.0 0.0 -0.429 149.0 149.0 SHH 0.022 0.057 -9999.0 0.0 -0.54 5.0 5.0 catabolic process -0.009 0.142 -9999.0 0.0 -0.377 9.0 9.0 SMO/Vitamin D3 0.004 0.144 -9999.0 0.0 -0.463 13.0 13.0 SHH Np/Cholesterol/Hhip -0.004 0.042 -9999.0 0.0 -0.419 5.0 5.0 LRP2 -0.19 0.331 -9999.0 0.0 -0.723 147.0 147.0 receptor-mediated endocytosis -0.117 0.168 -9999.0 0.0 -0.525 48.0 48.0 SHH Np/Cholesterol/BOC -0.098 0.18 -9999.0 0.0 -0.427 121.0 121.0 SHH Np/Cholesterol/CDO -0.008 0.06 -9999.0 0.0 -0.471 8.0 8.0 mesenchymal cell differentiation 0.004 0.041 0.417 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.012 0.121 -9999.0 0.0 -0.369 9.0 9.0 IHH N/PTCH2 0.023 0.023 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.011 0.064 -9999.0 0.0 -0.723 4.0 4.0 IHH N/PTCH1 -0.007 0.144 -9999.0 0.0 -0.379 9.0 9.0 Megalin/LRPAP1 -0.151 0.242 -9999.0 0.0 -0.54 147.0 147.0 PTCH2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.043 -9999.0 0.0 -0.431 5.0 5.0 PTCH1 -0.009 0.143 -9999.0 0.0 -0.378 9.0 9.0 HHIP 0.015 0.014 -9999.0 0.0 -9999.0 0.0 0.0