Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.002 0.106 -9999.0 0.0 -0.293 60.0 60.0 epithelial cell differentiation -0.026 0.1 -9999.0 0.0 -0.387 37.0 37.0 CYFIP2 -0.002 0.051 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.058 0.085 -9999.0 0.0 -0.434 2.0 2.0 EGFR -0.374 0.367 -9999.0 0.0 -0.723 277.0 277.0 EPHA2 0.005 0.09 -9999.0 0.0 -0.723 8.0 8.0 MYO6 0.019 0.108 -9999.0 0.0 -0.366 38.0 38.0 CTNNB1 0.01 0.064 -9999.0 0.0 -0.723 4.0 4.0 ABI1/Sra1/Nap1 0.009 0.026 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.178 0.258 -9999.0 0.0 -0.555 156.0 156.0 CTNND1 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.019 0.104 -9999.0 0.0 -0.357 37.0 37.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.151 -9999.0 0.0 -0.369 79.0 79.0 EGF -0.235 0.349 -9999.0 0.0 -0.723 178.0 178.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.081 0.2 -9999.0 0.0 -0.563 65.0 65.0 cortical microtubule organization -0.026 0.1 -9999.0 0.0 -0.387 37.0 37.0 GO:0000145 0.019 0.099 -9999.0 0.0 -0.341 37.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.026 0.101 -9999.0 0.0 -0.391 37.0 37.0 MLLT4 0.002 0.101 -9999.0 0.0 -0.723 10.0 10.0 ARF6/GDP -0.025 0.085 -9999.0 0.0 -0.641 2.0 2.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.004 0.053 -9999.0 0.0 -0.411 8.0 8.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.034 0.101 -9999.0 0.0 -0.328 37.0 37.0 PVRL2 0.01 0.032 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.018 0.107 -9999.0 0.0 -0.363 38.0 38.0 ARF6/GTP -0.003 0.048 -9999.0 0.0 -0.374 8.0 8.0 CDH1 -0.032 0.179 -9999.0 0.0 -0.723 33.0 33.0 EGFR/EGFR/EGF/EGF -0.329 0.255 -9999.0 0.0 -0.456 382.0 382.0 RhoA/GDP -0.024 0.092 -9999.0 0.0 -0.359 37.0 37.0 actin cytoskeleton organization 0.026 0.103 -9999.0 0.0 -0.344 38.0 38.0 IGF-1R heterotetramer -0.023 0.153 -9999.0 0.0 -0.721 23.0 23.0 GIT1 0.015 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.023 0.153 -9999.0 0.0 -0.723 23.0 23.0 IGF1 -0.351 0.369 -9999.0 0.0 -0.723 262.0 262.0 DIAPH1 0.012 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.026 0.1 0.387 37.0 -9999.0 0.0 37.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.025 0.086 -9999.0 0.0 -0.642 2.0 2.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.026 0.106 -9999.0 0.0 -0.352 38.0 38.0 EFNA1 0.013 0.022 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.029 0.101 -9999.0 0.0 -0.337 37.0 37.0 Ephrin A1/EPHA2 -0.028 0.103 -9999.0 0.0 -0.361 43.0 43.0 SEC6/SEC8 -0.027 0.091 -9999.0 0.0 -0.438 4.0 4.0 MGAT3 -0.015 0.153 -9999.0 0.0 -0.375 79.0 79.0 HGF/MET -0.057 0.14 -9999.0 0.0 -0.367 84.0 84.0 HGF 0.016 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.002 0.106 -9999.0 0.0 -0.295 60.0 60.0 actin cable formation 0.08 0.081 -9999.0 0.0 -0.35 2.0 2.0 KIAA1543 0.029 0.101 -9999.0 0.0 -0.337 37.0 37.0 KIFC3 0.019 0.105 -9999.0 0.0 -0.363 37.0 37.0 NCK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.019 0.105 -9999.0 0.0 -0.363 37.0 37.0 NCK1/GIT1 -0.001 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.026 0.1 -9999.0 0.0 -0.387 37.0 37.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.019 0.105 -9999.0 0.0 -0.363 37.0 37.0 PIP5K1C 0.019 0.105 -9999.0 0.0 -0.363 37.0 37.0 LIMA1 -0.016 0.151 -9999.0 0.0 -0.723 23.0 23.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.02 0.075 -9999.0 0.0 -0.537 2.0 2.0 adherens junction assembly 0.05 0.097 -9999.0 0.0 -0.368 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.214 0.216 -9999.0 0.0 -0.391 290.0 290.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.014 0.075 -9999.0 0.0 -0.54 10.0 10.0 MET -0.057 0.22 -9999.0 0.0 -0.723 52.0 52.0 PLEKHA7 0.019 0.105 -9999.0 0.0 -0.363 37.0 37.0 mol:GTP -0.004 0.052 -9999.0 0.0 -0.408 8.0 8.0 establishment of epithelial cell apical/basal polarity 0.044 0.108 -9999.0 0.0 -0.619 1.0 1.0 cortical actin cytoskeleton stabilization 0.002 0.106 -9999.0 0.0 -0.293 60.0 60.0 regulation of cell-cell adhesion 0.026 0.103 -9999.0 0.0 -0.344 38.0 38.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.002 0.106 -9999.0 0.0 -0.295 60.0 60.0