E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.148 -9999.0 0.0 -0.431 42.0 42.0 KLHL20 0.041 0.115 0.307 40.0 -0.258 14.0 54.0 CYFIP2 0.049 0.045 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.002 0.117 0.312 7.0 -0.349 5.0 12.0 ENAH -0.031 0.142 -9999.0 0.0 -0.436 33.0 33.0 AP1M1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.045 -9999.0 0.0 -0.543 3.0 3.0 CDC42/GTP 0.009 0.075 -9999.0 0.0 -0.29 2.0 2.0 ABI1/Sra1/Nap1 -0.016 0.04 -9999.0 0.0 -0.175 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.094 -9999.0 0.0 -0.311 25.0 25.0 RAPGEF1 -0.029 0.141 0.311 2.0 -0.402 36.0 38.0 CTNND1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.163 -9999.0 0.0 -0.439 49.0 49.0 CRK -0.027 0.144 0.345 1.0 -0.43 37.0 38.0 E-cadherin/gamma catenin/alpha catenin 0.036 0.089 -9999.0 0.0 -0.343 21.0 21.0 alphaE/beta7 Integrin 0.046 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.042 -9999.0 0.0 -0.31 3.0 3.0 DLG1 -0.039 0.157 -9999.0 0.0 -0.433 47.0 47.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.06 -9999.0 0.0 -0.205 6.0 6.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.543 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.021 0.079 -9999.0 0.0 -0.269 5.0 5.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.096 -9999.0 0.0 -0.326 31.0 31.0 TIAM1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.046 0.088 -9999.0 0.0 -0.293 25.0 25.0 AKT1 -0.007 0.056 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.019 0.164 -9999.0 0.0 -0.543 45.0 45.0 CDH1 0.006 0.119 -9999.0 0.0 -0.543 22.0 22.0 RhoA/GDP 0.001 0.116 0.305 7.0 -0.3 24.0 31.0 actin cytoskeleton organization 0.036 0.093 0.253 44.0 -0.19 12.0 56.0 CDC42/GDP 0.001 0.116 0.305 7.0 -0.347 5.0 12.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.067 -9999.0 0.0 -0.237 30.0 30.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.094 -9999.0 0.0 -0.311 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.081 -9999.0 0.0 -0.29 25.0 25.0 mol:GDP -0.018 0.123 0.309 7.0 -0.346 24.0 31.0 CDC42/GTP/IQGAP1 0.043 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.007 0.119 0.318 5.0 -0.371 4.0 9.0 RAC1/GTP/IQGAP1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.067 0.2 25.0 -0.226 11.0 36.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.157 -9999.0 0.0 -0.443 44.0 44.0 regulation of cell-cell adhesion -0.0 0.061 -9999.0 0.0 -0.255 2.0 2.0 WASF2 0.019 0.043 0.118 31.0 -0.119 2.0 33.0 Rap1/GTP 0.012 0.086 0.281 1.0 -0.327 2.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.092 -9999.0 0.0 -0.299 21.0 21.0 CCND1 0.016 0.079 0.234 22.0 -0.284 11.0 33.0 VAV2 -0.019 0.192 0.41 1.0 -0.675 15.0 16.0 RAP1/GDP 0.01 0.1 0.31 3.0 -0.359 3.0 6.0 adherens junction assembly -0.034 0.153 -9999.0 0.0 -0.428 44.0 44.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.044 0.088 -9999.0 0.0 -0.289 23.0 23.0 E-cadherin/beta catenin -0.007 0.089 -9999.0 0.0 -0.336 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.038 0.156 -9999.0 0.0 -0.436 45.0 45.0 PIK3CA 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.011 0.144 0.278 57.0 -0.425 17.0 74.0 E-cadherin/beta catenin/alpha catenin 0.036 0.094 -9999.0 0.0 -0.339 25.0 25.0 ITGAE 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.032 0.166 -9999.0 0.0 -0.448 49.0 49.0