Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.196 0.322 -9999.0 0.0 -0.631 28.0 28.0 IHH -0.082 0.18 -9999.0 0.0 -0.557 11.0 11.0 SHH Np/Cholesterol/GAS1 -0.074 0.168 -9999.0 0.0 -0.435 11.0 11.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.074 0.166 0.432 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.141 0.232 -9999.0 0.0 -0.563 16.0 16.0 SMO -0.154 0.244 -9999.0 0.0 -0.585 17.0 17.0 AKT1 -0.064 0.136 -9999.0 0.0 -0.658 2.0 2.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.029 0.15 -9999.0 0.0 -0.563 7.0 7.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.152 0.24 -9999.0 0.0 -0.574 17.0 17.0 STIL -0.117 0.217 -9999.0 0.0 -0.579 12.0 12.0 DHH N/PTCH2 -0.014 0.115 -9999.0 0.0 -0.424 7.0 7.0 DHH N/PTCH1 -0.109 0.204 -9999.0 0.0 -0.518 13.0 13.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.006 0.098 -9999.0 0.0 -0.55 3.0 3.0 PTHLH -0.277 0.436 -9999.0 0.0 -0.997 22.0 22.0 determination of left/right symmetry -0.152 0.24 -9999.0 0.0 -0.574 17.0 17.0 PIK3R1 -0.017 0.127 -9999.0 0.0 -0.559 5.0 5.0 skeletal system development -0.273 0.429 -9999.0 0.0 -0.981 22.0 22.0 IHH N/Hhip -0.086 0.184 -9999.0 0.0 -0.439 19.0 19.0 DHH N/Hhip -0.043 0.151 -9999.0 0.0 -0.413 13.0 13.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.152 0.24 -9999.0 0.0 -0.574 17.0 17.0 pancreas development -0.056 0.169 -9999.0 0.0 -0.505 12.0 12.0 HHAT -0.008 0.113 -9999.0 0.0 -0.639 3.0 3.0 PI3K -0.003 0.094 -9999.0 0.0 -0.402 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.059 0.19 -9999.0 0.0 -0.561 12.0 12.0 somite specification -0.152 0.24 -9999.0 0.0 -0.574 17.0 17.0 SHH Np/Cholesterol/PTCH1 -0.13 0.228 -9999.0 0.0 -0.554 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.049 0.14 -9999.0 0.0 -0.381 10.0 10.0 SHH Np/Cholesterol/Megalin -0.069 0.154 -9999.0 0.0 -0.438 8.0 8.0 SHH -0.053 0.156 -9999.0 0.0 -0.4 16.0 16.0 catabolic process -0.118 0.213 -9999.0 0.0 -0.543 12.0 12.0 SMO/Vitamin D3 -0.151 0.242 -9999.0 0.0 -0.595 17.0 17.0 SHH Np/Cholesterol/Hhip -0.074 0.168 -9999.0 0.0 -0.45 12.0 12.0 LRP2 -0.049 0.164 -9999.0 0.0 -0.506 11.0 11.0 receptor-mediated endocytosis -0.162 0.226 -9999.0 0.0 -0.557 19.0 19.0 SHH Np/Cholesterol/BOC -0.058 0.148 -9999.0 0.0 -0.408 8.0 8.0 SHH Np/Cholesterol/CDO -0.042 0.129 -9999.0 0.0 -0.365 8.0 8.0 mesenchymal cell differentiation 0.074 0.166 0.446 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 -0.129 0.23 -9999.0 0.0 -0.555 16.0 16.0 IHH N/PTCH2 -0.055 0.151 -9999.0 0.0 -0.393 14.0 14.0 CDON -0.001 0.093 -9999.0 0.0 -0.639 2.0 2.0 IHH N/PTCH1 -0.119 0.215 -9999.0 0.0 -0.549 12.0 12.0 Megalin/LRPAP1 -0.026 0.118 -9999.0 0.0 -0.357 11.0 11.0 PTCH2 -0.013 0.123 -9999.0 0.0 -0.605 4.0 4.0 SHH Np/Cholesterol -0.047 0.118 -9999.0 0.0 -0.31 16.0 16.0 PTCH1 -0.119 0.213 -9999.0 0.0 -0.546 12.0 12.0 HHIP -0.056 0.169 -9999.0 0.0 -0.506 12.0 12.0