Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	19.0	1193.0	60.0	-0.703	0.012	1000.0	-1000.0	-0.161	-1000.0
IL4-mediated signaling events	14.0	1281.0	91.0	-0.794	0.673	1000.0	-1000.0	-0.161	-1000.0
HIF-1-alpha transcription factor network	13.0	1060.0	76.0	-0.6	0.02	1000.0	-1000.0	-0.194	-1000.0
p75(NTR)-mediated signaling	13.0	1659.0	125.0	-0.239	0.033	1000.0	-1000.0	-0.099	-1000.0
Glypican 2 network	13.0	55.0	4.0	-0.095	-0.075	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by the Hedgehog family	10.0	567.0	52.0	-0.277	0.074	1000.0	-1000.0	-0.057	-1000.0
BMP receptor signaling	10.0	871.0	81.0	-0.248	0.027	1000.0	-1000.0	-0.089	-1000.0
Glucocorticoid receptor regulatory network	10.0	1227.0	114.0	-0.636	0.316	1000.0	-1000.0	-0.074	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	969.0	93.0	-0.189	0.104	1000.0	-1000.0	-0.078	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	9.0	315.0	34.0	-0.093	0.012	1000.0	-1000.0	-0.053	-1000.0
IL12-mediated signaling events	9.0	807.0	87.0	-0.317	0.1	1000.0	-1000.0	-0.138	-1000.0
Syndecan-1-mediated signaling events	9.0	326.0	34.0	-0.222	0.012	1000.0	-1000.0	-0.062	-1000.0
Glypican 1 network	9.0	446.0	48.0	-0.15	0.021	1000.0	-1000.0	-0.038	-1000.0
Wnt signaling	9.0	63.0	7.0	-0.103	0.012	1000.0	-1000.0	-0.032	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	387.0	46.0	-0.398	0.019	1000.0	-1000.0	-0.093	-1000.0
amb2 Integrin signaling	8.0	703.0	82.0	-0.139	0.017	1000.0	-1000.0	-0.075	-1000.0
Signaling mediated by p38-alpha and p38-beta	8.0	359.0	44.0	-0.24	0.012	1000.0	-1000.0	-0.058	-1000.0
Effects of Botulinum toxin	8.0	213.0	26.0	-0.204	0.012	1000.0	-1000.0	-0.059	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	8.0	565.0	68.0	-0.364	0.079	1000.0	-1000.0	-0.129	-1000.0
BCR signaling pathway	8.0	869.0	99.0	-0.192	0.023	1000.0	-1000.0	-0.092	-1000.0
EGFR-dependent Endothelin signaling events	8.0	168.0	21.0	-0.121	0.018	1000.0	-1000.0	-0.063	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	991.0	120.0	-0.278	0.21	1000.0	-1000.0	-0.07	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.037	-1000.0	1000.0	-1000.0	-0.012	-1000.0
Syndecan-2-mediated signaling events	7.0	501.0	69.0	-0.128	0.024	1000.0	-1000.0	-0.036	-1000.0
Nectin adhesion pathway	7.0	448.0	63.0	-0.108	0.024	1000.0	-1000.0	-0.07	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	634.0	82.0	-0.122	0.012	1000.0	-1000.0	-0.086	-1000.0
Endothelins	7.0	762.0	96.0	-0.27	0.043	1000.0	-1000.0	-0.087	-1000.0
Integrins in angiogenesis	7.0	610.0	84.0	-0.185	0.018	1000.0	-1000.0	-0.089	-1000.0
EPHB forward signaling	7.0	649.0	85.0	-0.125	0.1	1000.0	-1000.0	-0.089	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	235.0	31.0	-0.26	0.013	1000.0	-1000.0	-0.092	-1000.0
ErbB4 signaling events	6.0	432.0	69.0	-0.193	0.069	1000.0	-1000.0	-0.101	-1000.0
Osteopontin-mediated events	6.0	238.0	38.0	-0.117	0.012	1000.0	-1000.0	-0.096	-1000.0
Noncanonical Wnt signaling pathway	6.0	157.0	26.0	-0.103	0.012	1000.0	-1000.0	-0.056	-1000.0
Thromboxane A2 receptor signaling	6.0	655.0	105.0	-0.121	0.031	1000.0	-1000.0	-0.066	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	585.0	97.0	-0.13	0.028	1000.0	-1000.0	-0.088	-1000.0
IL27-mediated signaling events	6.0	336.0	51.0	-0.149	0.084	1000.0	-1000.0	-0.082	-1000.0
LPA receptor mediated events	6.0	640.0	102.0	-0.126	0.018	1000.0	-1000.0	-0.085	-1000.0
Syndecan-4-mediated signaling events	6.0	426.0	67.0	-0.128	0.024	1000.0	-1000.0	-0.093	-1000.0
IGF1 pathway	6.0	347.0	57.0	-0.12	0.025	1000.0	-1000.0	-0.096	-1000.0
Plasma membrane estrogen receptor signaling	6.0	579.0	86.0	-0.115	0.077	1000.0	-1000.0	-0.084	-1000.0
LPA4-mediated signaling events	5.0	64.0	12.0	-0.075	0.018	1000.0	-1000.0	-0.034	-1000.0
Caspase cascade in apoptosis	5.0	399.0	74.0	-0.094	0.038	1000.0	-1000.0	-0.039	-1000.0
Coregulation of Androgen receptor activity	5.0	418.0	76.0	-0.179	0.022	1000.0	-1000.0	-0.037	-1000.0
Ephrin A  reverse signaling	5.0	41.0	7.0	-0.016	-0.0	1000.0	-1000.0	-0.018	-1000.0
Cellular roles of Anthrax toxin	5.0	195.0	39.0	-0.088	0.012	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	5.0	327.0	62.0	-0.121	0.016	1000.0	-1000.0	-0.061	-1000.0
Reelin signaling pathway	5.0	284.0	56.0	-0.168	0.018	1000.0	-1000.0	-0.076	-1000.0
IL1-mediated signaling events	5.0	310.0	62.0	-0.151	0.06	1000.0	-1000.0	-0.093	-1000.0
S1P5 pathway	5.0	95.0	17.0	-0.075	0.069	1000.0	-1000.0	-0.034	-1000.0
Ephrin B reverse signaling	5.0	279.0	48.0	-0.119	0.083	1000.0	-1000.0	-0.068	-1000.0
Nongenotropic Androgen signaling	5.0	267.0	52.0	-0.116	0.017	1000.0	-1000.0	-0.06	-1000.0
IL6-mediated signaling events	5.0	437.0	75.0	-0.121	0.044	1000.0	-1000.0	-0.082	-1000.0
Visual signal transduction: Cones	4.0	155.0	38.0	-0.093	0.012	1000.0	-1000.0	-0.064	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	73.0	17.0	-0.033	0.012	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by PTP1B	4.0	374.0	76.0	-0.195	0.02	1000.0	-1000.0	-0.092	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	273.0	61.0	-0.151	0.03	1000.0	-1000.0	-0.081	-1000.0
TRAIL signaling pathway	4.0	203.0	48.0	-0.048	0.015	1000.0	-1000.0	-0.068	-1000.0
Syndecan-3-mediated signaling events	4.0	163.0	35.0	-0.184	0.033	1000.0	-1000.0	-0.048	-1000.0
Canonical Wnt signaling pathway	4.0	243.0	51.0	-0.151	0.067	1000.0	-1000.0	-0.069	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	400.0	88.0	-0.155	0.03	1000.0	-1000.0	-0.114	-1000.0
Visual signal transduction: Rods	4.0	254.0	52.0	-0.182	0.012	1000.0	-1000.0	-0.078	-1000.0
BARD1 signaling events	3.0	177.0	57.0	-0.041	0.032	1000.0	-1000.0	-0.062	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	104.0	28.0	-0.075	0.03	1000.0	-1000.0	-0.035	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	252.0	65.0	-0.3	0.036	1000.0	-1000.0	-0.061	-1000.0
PDGFR-alpha signaling pathway	3.0	175.0	44.0	-0.07	0.021	1000.0	-1000.0	-0.042	-1000.0
S1P1 pathway	3.0	126.0	36.0	-0.098	0.012	1000.0	-1000.0	-0.055	-1000.0
IL2 signaling events mediated by PI3K	3.0	187.0	58.0	-0.071	0.027	1000.0	-1000.0	-0.082	-1000.0
IL2 signaling events mediated by STAT5	3.0	70.0	22.0	-0.042	0.028	1000.0	-1000.0	-0.054	-1000.0
TCGA08_retinoblastoma	3.0	29.0	8.0	-0.012	0.012	1000.0	-1000.0	-0.018	-1000.0
Regulation of Telomerase	3.0	330.0	102.0	-0.175	0.036	1000.0	-1000.0	-0.1	-1000.0
S1P3 pathway	3.0	136.0	42.0	-0.059	0.024	1000.0	-1000.0	-0.033	-1000.0
S1P4 pathway	3.0	86.0	25.0	-0.075	0.02	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	270.0	78.0	-0.051	0.032	1000.0	-1000.0	-0.074	-1000.0
Regulation of Androgen receptor activity	3.0	275.0	70.0	-0.242	0.027	1000.0	-1000.0	-0.068	-1000.0
ErbB2/ErbB3 signaling events	2.0	160.0	65.0	-0.115	0.021	1000.0	-1000.0	-0.066	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	354.0	136.0	-0.189	0.063	1000.0	-1000.0	-0.075	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	117.0	54.0	-0.069	0.025	1000.0	-1000.0	-0.098	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	12.0	5.0	-0.013	0.012	1000.0	-1000.0	-0.028	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	196.0	85.0	-0.045	0.02	1000.0	-1000.0	-0.08	-1000.0
IFN-gamma pathway	2.0	203.0	68.0	-0.147	0.022	1000.0	-1000.0	-0.107	-1000.0
Ceramide signaling pathway	2.0	189.0	76.0	-0.121	0.035	1000.0	-1000.0	-0.045	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	81.0	37.0	-0.043	0.018	1000.0	-1000.0	-0.053	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	140.0	52.0	-0.095	0.04	1000.0	-1000.0	-0.051	-1000.0
FAS signaling pathway (CD95)	2.0	99.0	47.0	-0.055	0.015	1000.0	-1000.0	-0.045	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	43.0	15.0	-0.028	0.023	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	2.0	143.0	58.0	-0.092	0.025	1000.0	-1000.0	-0.069	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	194.0	74.0	-0.19	0.058	1000.0	-1000.0	-0.083	-1000.0
Class I PI3K signaling events	2.0	162.0	73.0	-0.108	0.021	1000.0	-1000.0	-0.071	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	66.0	33.0	-0.111	0.03	1000.0	-1000.0	-0.052	-1000.0
Rapid glucocorticoid signaling	2.0	54.0	20.0	-0.056	0.014	1000.0	-1000.0	-0.02	-1000.0
p38 MAPK signaling pathway	2.0	92.0	44.0	-0.119	0.024	1000.0	-1000.0	-0.062	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	47.0	17.0	-0.02	0.02	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	1.0	47.0	39.0	-0.048	0.062	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by HDAC Class II	1.0	86.0	75.0	-0.083	0.033	1000.0	-1000.0	-0.048	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	0.0	0.012	1000.0	-1000.0	-0.011	-1000.0
Aurora A signaling	1.0	108.0	60.0	-0.167	0.037	1000.0	-1000.0	-0.046	-1000.0
Insulin-mediated glucose transport	1.0	33.0	32.0	-0.041	0.044	1000.0	-1000.0	-0.063	-1000.0
mTOR signaling pathway	1.0	55.0	53.0	-0.023	0.019	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by HDAC Class III	1.0	76.0	40.0	-0.175	0.021	1000.0	-1000.0	-0.037	-1000.0
ceramide signaling pathway	1.0	50.0	49.0	-0.048	0.026	1000.0	-1000.0	-0.048	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	86.0	83.0	-0.041	0.052	1000.0	-1000.0	-0.077	-1000.0
TCGA08_p53	1.0	7.0	7.0	-0.007	0.012	1000.0	-1000.0	-0.012	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	64.0	36.0	-0.043	0.025	1000.0	-1000.0	-0.072	-1000.0
Atypical NF-kappaB pathway	1.0	44.0	31.0	-0.02	0.04	1000.0	-1000.0	-0.039	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	80.0	45.0	-0.067	0.036	1000.0	-1000.0	-0.089	-1000.0
Regulation of p38-alpha and p38-beta	1.0	106.0	54.0	-0.108	0.032	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	145.0	125.0	-0.08	0.051	1000.0	-1000.0	-0.084	-1000.0
TCGA08_rtk_signaling	1.0	45.0	26.0	-0.033	0.033	1000.0	-1000.0	-0.022	-1000.0
Insulin Pathway	1.0	126.0	74.0	-0.155	0.034	1000.0	-1000.0	-0.09	-1000.0
PDGFR-beta signaling pathway	1.0	156.0	97.0	-0.07	0.038	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by PRL	1.0	51.0	34.0	-0.085	0.034	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling in keratinocytes	1.0	50.0	43.0	-0.033	0.033	1000.0	-1000.0	-0.063	-1000.0
FOXM1 transcription factor network	1.0	78.0	51.0	-0.088	0.125	1000.0	-1000.0	-0.18	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	18.0	23.0	-0.035	0.04	1000.0	-1000.0	-0.056	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.018	0.04	1000.0	-1000.0	-0.045	-1000.0
Arf6 downstream pathway	0.0	31.0	43.0	-0.033	0.025	1000.0	-1000.0	-0.041	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.002	0.016	1000.0	-1000.0	-0.022	-1000.0
EPO signaling pathway	0.0	46.0	55.0	-0.024	0.06	1000.0	-1000.0	-0.092	-1000.0
PLK1 signaling events	0.0	24.0	85.0	-0.011	0.034	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	25.0	68.0	-0.041	0.045	1000.0	-1000.0	-0.055	-1000.0
HIF-2-alpha transcription factor network	0.0	35.0	43.0	-0.085	0.087	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by HDAC Class I	0.0	64.0	104.0	-0.048	0.049	1000.0	-1000.0	-0.069	-1000.0
FoxO family signaling	0.0	39.0	64.0	-0.058	0.129	1000.0	-1000.0	-0.078	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	59.0	76.0	-0.045	0.05	1000.0	-1000.0	-0.085	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.032	1000.0	-1000.0	-0.055	-1000.0
Arf6 trafficking events	0.0	44.0	71.0	-0.033	0.04	1000.0	-1000.0	-0.073	-1000.0
VEGFR1 specific signals	0.0	41.0	56.0	-0.026	0.044	1000.0	-1000.0	-0.06	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.012	0.025	1000.0	-1000.0	-0.027	-1000.0
Arf1 pathway	0.0	16.0	54.0	-0.025	0.025	1000.0	-1000.0	-0.036	-1000.0
Alternative NF-kappaB pathway	0.0	9.0	13.0	0.0	0.031	1000.0	-1000.0	-0.028	-1000.0
Aurora B signaling	0.0	44.0	67.0	-0.063	0.034	1000.0	-1000.0	-0.07	-1000.0
Total	530	35188	7203	-16.5339075002	-994.588934658	131000	-131000	-8.74701496242	-131000