Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.015 0.054 -9999.0 0.0 -0.336 2.0 2.0 epithelial cell differentiation 0.048 0.044 -9999.0 0.0 -0.311 1.0 1.0 CYFIP2 0.009 0.093 -9999.0 0.0 -0.388 4.0 4.0 ENAH 0.014 0.099 0.281 4.0 -0.376 1.0 5.0 EGFR -0.011 0.147 -9999.0 0.0 -0.571 6.0 6.0 EPHA2 0.002 0.121 -9999.0 0.0 -0.571 4.0 4.0 MYO6 0.009 0.032 -9999.0 0.0 -0.301 1.0 1.0 CTNNB1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.037 0.07 -9999.0 0.0 -0.363 2.0 2.0 AQP5 -0.147 0.226 -9999.0 0.0 -0.482 28.0 28.0 CTNND1 0.022 0.062 -9999.0 0.0 -0.571 1.0 1.0 mol:PI-4-5-P2 0.01 0.037 -9999.0 0.0 -0.297 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.02 0.079 -9999.0 0.0 -0.294 5.0 5.0 EGF -0.067 0.19 -9999.0 0.0 -0.38 21.0 21.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.062 0.187 -9999.0 0.0 -0.496 14.0 14.0 cortical microtubule organization 0.048 0.044 -9999.0 0.0 -0.311 1.0 1.0 GO:0000145 -0.008 0.035 0.175 1.0 -0.284 1.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.046 -9999.0 0.0 -0.314 1.0 1.0 MLLT4 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.023 0.066 -9999.0 0.0 -0.356 3.0 3.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.036 0.078 -9999.0 0.0 -0.334 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.001 0.029 -9999.0 0.0 -0.274 1.0 1.0 PVRL2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.01 0.037 -9999.0 0.0 -0.301 1.0 1.0 ARF6/GTP 0.039 0.077 -9999.0 0.0 -0.313 3.0 3.0 CDH1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.03 0.146 -9999.0 0.0 -0.335 15.0 15.0 RhoA/GDP 0.048 0.044 -9999.0 0.0 -0.298 1.0 1.0 actin cytoskeleton organization -0.012 0.03 -9999.0 0.0 -0.294 1.0 1.0 IGF-1R heterotetramer 0.021 0.062 -9999.0 0.0 -0.57 1.0 1.0 GIT1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.021 0.062 -9999.0 0.0 -0.571 1.0 1.0 IGF1 -0.08 0.221 -9999.0 0.0 -0.479 20.0 20.0 DIAPH1 -0.02 0.199 -9999.0 0.0 -0.568 7.0 7.0 Wnt receptor signaling pathway -0.048 0.044 0.311 1.0 -9999.0 0.0 1.0 RHOA 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.023 0.066 -9999.0 0.0 -0.515 1.0 1.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.012 0.03 -9999.0 0.0 -0.3 1.0 1.0 EFNA1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.008 0.031 -9999.0 0.0 -0.29 1.0 1.0 Ephrin A1/EPHA2 0.024 0.089 -9999.0 0.0 -0.365 4.0 4.0 SEC6/SEC8 0.006 0.031 -9999.0 0.0 -0.283 1.0 1.0 MGAT3 -0.021 0.08 -9999.0 0.0 -0.298 5.0 5.0 HGF/MET 0.017 0.102 -9999.0 0.0 -0.34 6.0 6.0 HGF 0.005 0.108 -9999.0 0.0 -0.479 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.015 0.055 -9999.0 0.0 -0.339 2.0 2.0 actin cable formation 0.062 0.144 0.331 12.0 -0.294 1.0 13.0 KIAA1543 -0.02 0.058 -9999.0 0.0 -0.29 4.0 4.0 KIFC3 0.007 0.049 -9999.0 0.0 -0.303 2.0 2.0 NCK1 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.01 0.037 -9999.0 0.0 -0.301 1.0 1.0 NCK1/GIT1 0.032 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.044 -9999.0 0.0 -0.311 1.0 1.0 EXOC4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.011 0.037 -9999.0 0.0 -0.301 1.0 1.0 PIP5K1C 0.011 0.037 -9999.0 0.0 -0.301 1.0 1.0 LIMA1 0.022 0.062 -9999.0 0.0 -0.571 1.0 1.0 ABI1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.033 0.117 0.298 7.0 -0.448 1.0 8.0 adherens junction assembly -0.023 0.116 -9999.0 0.0 -0.455 5.0 5.0 IGF-1R heterotetramer/IGF1 -0.023 0.141 -9999.0 0.0 -0.315 16.0 16.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.106 -9999.0 0.0 -0.571 3.0 3.0 PLEKHA7 -0.002 0.064 -9999.0 0.0 -0.304 4.0 4.0 mol:GTP 0.034 0.077 -9999.0 0.0 -0.332 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.038 0.099 0.323 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization 0.015 0.054 -9999.0 0.0 -0.336 2.0 2.0 regulation of cell-cell adhesion -0.012 0.03 -9999.0 0.0 -0.294 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.015 0.055 -9999.0 0.0 -0.339 2.0 2.0