This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.
Testing the association between subtypes identified by 68 different clustering approaches and 9 clinical features across 413 patients, 35 significant findings detected with Q value < 0.25.
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2 subtypes identified in current cancer cohort by 'Amp Peak 1(2q33.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 2(5p13.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 3(5q22.3) mutation analysis'. These subtypes do not correlate to any clinical features.
-
2 subtypes identified in current cancer cohort by 'Amp Peak 4(6p21.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 5(8p11.23) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 6(8p11.21) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 7(8q12.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 8(8q24.21) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 9(11p15.5) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 10(12p13.33) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 11(13q12.13) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by 'Amp Peak 12(13q22.1) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE' and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Amp Peak 13(16p11.2) mutation analysis'. These subtypes correlate to 'PATHOLOGY.N' and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Amp Peak 14(16q12.1) mutation analysis'. These subtypes correlate to 'PATHOLOGY.N' and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Amp Peak 15(17q12) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 16(17q24.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 17(19p13.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 18(19q13.11) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 19(20p12.3) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 20(20p11.23) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 21(20p11.21) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Amp Peak 22(20q11.21) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by 'Amp Peak 23(20q12) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by 'Amp Peak 24(20q13.32) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by 'Del Peak 1(1p36.11) mutation analysis'. These subtypes correlate to 'PATHOLOGICSPREAD(M)'.
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2 subtypes identified in current cancer cohort by 'Del Peak 2(1p33) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 3(1p13.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 4(1q43) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 5(2q37.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 6(3p26.1) mutation analysis'. These subtypes correlate to 'Time to Death'.
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2 subtypes identified in current cancer cohort by 'Del Peak 7(3p14.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 8(3q26.31) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 9(4p16.2) mutation analysis'. These subtypes correlate to 'Time to Death', 'PATHOLOGY.N', and 'PATHOLOGICSPREAD(M)'.
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2 subtypes identified in current cancer cohort by 'Del Peak 10(4q22.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 11(4q35.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 12(5q11.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 13(5q21.3) mutation analysis'. These subtypes correlate to 'PATHOLOGY.N'.
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2 subtypes identified in current cancer cohort by 'Del Peak 14(5q23.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 15(6p25.3) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 16(6q26) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 17(7q31.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 18(8p23.3) mutation analysis'. These subtypes correlate to 'PATHOLOGY.N' and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Del Peak 19(8p22) mutation analysis'. These subtypes correlate to 'PATHOLOGY.N' and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Del Peak 20(8p11.22) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 21(8p11.21) mutation analysis'. These subtypes correlate to 'PATHOLOGY.N'.
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2 subtypes identified in current cancer cohort by 'Del Peak 22(9p21.3) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 23(10p15.3) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 24(10q21.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 25(10q23.31) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 26(10q25.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 27(12p13.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 28(13q14.13) mutation analysis'. These subtypes correlate to 'PATHOLOGICSPREAD(M)'.
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2 subtypes identified in current cancer cohort by 'Del Peak 29(14q32.11) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 30(15q11.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 31(15q21.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 32(15q22.33) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 33(16p13.3) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 34(16q23.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 35(17p12) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE', 'PATHOLOGY.N', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Del Peak 36(17q24.3) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 37(18p11.31) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by 'Del Peak 38(18q12.2) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE' and 'TUMOR.STAGE'.
-
2 subtypes identified in current cancer cohort by 'Del Peak 39(18q21.2) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE', 'PATHOLOGY.N', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Del Peak 40(18q22.1) mutation analysis'. These subtypes correlate to 'HISTOLOGICAL.TYPE', 'PATHOLOGY.N', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Del Peak 41(19p13.3) mutation analysis'. These subtypes correlate to 'PATHOLOGY.N'.
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2 subtypes identified in current cancer cohort by 'Del Peak 42(20p12.1) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 43(21q11.2) mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'Del Peak 44(22q13.32) mutation analysis'. These subtypes do not correlate to any clinical features.
Clinical Features |
Time to Death |
AGE | GENDER |
HISTOLOGICAL TYPE |
PATHOLOGY T |
PATHOLOGY N |
PATHOLOGICSPREAD(M) |
TUMOR STAGE |
RADIATIONS RADIATION REGIMENINDICATION |
Statistical Tests | logrank test | t-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Chi-square test | Fisher's exact test | Fisher's exact test |
Amp Peak 1(2q33 1) |
0.0421 (1.00) |
0.358 (1.00) |
0.259 (1.00) |
0.267 (1.00) |
0.834 (1.00) |
0.0212 (1.00) |
0.639 (1.00) |
0.0501 (1.00) |
0.472 (1.00) |
Amp Peak 2(5p13 2) |
0.344 (1.00) |
0.234 (1.00) |
0.322 (1.00) |
0.856 (1.00) |
0.521 (1.00) |
0.034 (1.00) |
0.729 (1.00) |
0.771 (1.00) |
1 (1.00) |
Amp Peak 3(5q22 3) |
0.975 (1.00) |
0.768 (1.00) |
0.74 (1.00) |
0.332 (1.00) |
0.781 (1.00) |
0.201 (1.00) |
0.00941 (1.00) |
0.0736 (1.00) |
0.264 (1.00) |
Amp Peak 4(6p21 1) |
0.855 (1.00) |
0.829 (1.00) |
0.283 (1.00) |
0.0505 (1.00) |
0.568 (1.00) |
0.00138 (0.772) |
0.609 (1.00) |
0.0106 (1.00) |
0.00974 (1.00) |
Amp Peak 5(8p11 23) |
0.875 (1.00) |
0.293 (1.00) |
0.757 (1.00) |
0.168 (1.00) |
0.791 (1.00) |
0.721 (1.00) |
0.569 (1.00) |
0.928 (1.00) |
0.279 (1.00) |
Amp Peak 6(8p11 21) |
0.419 (1.00) |
0.449 (1.00) |
0.272 (1.00) |
0.184 (1.00) |
0.765 (1.00) |
0.556 (1.00) |
0.466 (1.00) |
0.958 (1.00) |
0.574 (1.00) |
Amp Peak 7(8q12 1) |
0.858 (1.00) |
0.113 (1.00) |
0.844 (1.00) |
0.0189 (1.00) |
0.417 (1.00) |
0.362 (1.00) |
0.158 (1.00) |
0.394 (1.00) |
0.249 (1.00) |
Amp Peak 8(8q24 21) |
0.637 (1.00) |
0.074 (1.00) |
0.485 (1.00) |
0.0753 (1.00) |
0.2 (1.00) |
0.282 (1.00) |
0.0847 (1.00) |
0.25 (1.00) |
0.267 (1.00) |
Amp Peak 9(11p15 5) |
0.603 (1.00) |
0.0407 (1.00) |
0.544 (1.00) |
0.00194 (1.00) |
0.151 (1.00) |
0.276 (1.00) |
0.254 (1.00) |
0.154 (1.00) |
0.111 (1.00) |
Amp Peak 10(12p13 33) |
0.2 (1.00) |
0.139 (1.00) |
0.734 (1.00) |
0.501 (1.00) |
0.16 (1.00) |
0.144 (1.00) |
0.2 (1.00) |
0.112 (1.00) |
0.575 (1.00) |
Amp Peak 11(13q12 13) |
0.29 (1.00) |
0.522 (1.00) |
0.92 (1.00) |
8.87e-07 (0.000538) |
0.966 (1.00) |
0.00311 (1.00) |
0.00471 (1.00) |
0.000464 (0.267) |
0.282 (1.00) |
Amp Peak 12(13q22 1) |
0.0716 (1.00) |
0.565 (1.00) |
0.363 (1.00) |
8.13e-06 (0.00488) |
1 (1.00) |
0.00143 (0.797) |
0.00698 (1.00) |
0.000315 (0.183) |
0.288 (1.00) |
Amp Peak 13(16p11 2) |
0.426 (1.00) |
0.0688 (1.00) |
0.584 (1.00) |
0.00867 (1.00) |
0.48 (1.00) |
0.000142 (0.0833) |
0.323 (1.00) |
0.000162 (0.0949) |
1 (1.00) |
Amp Peak 14(16q12 1) |
0.356 (1.00) |
0.0166 (1.00) |
0.493 (1.00) |
0.0112 (1.00) |
0.947 (1.00) |
0.000185 (0.108) |
0.18 (1.00) |
3e-05 (0.0179) |
0.574 (1.00) |
Amp Peak 15(17q12) |
0.479 (1.00) |
0.45 (1.00) |
0.252 (1.00) |
0.313 (1.00) |
0.25 (1.00) |
0.113 (1.00) |
0.0126 (1.00) |
0.0172 (1.00) |
0.57 (1.00) |
Amp Peak 16(17q24 1) |
0.076 (1.00) |
0.414 (1.00) |
0.638 (1.00) |
0.112 (1.00) |
0.409 (1.00) |
0.341 (1.00) |
0.0351 (1.00) |
0.21 (1.00) |
0.531 (1.00) |
Amp Peak 17(19p13 2) |
0.63 (1.00) |
0.618 (1.00) |
0.0575 (1.00) |
0.228 (1.00) |
0.655 (1.00) |
0.0194 (1.00) |
0.00672 (1.00) |
0.231 (1.00) |
0.403 (1.00) |
Amp Peak 18(19q13 11) |
0.201 (1.00) |
0.68 (1.00) |
0.0648 (1.00) |
0.364 (1.00) |
0.942 (1.00) |
0.129 (1.00) |
0.0224 (1.00) |
0.486 (1.00) |
0.491 (1.00) |
Amp Peak 19(20p12 3) |
0.0533 (1.00) |
0.491 (1.00) |
0.197 (1.00) |
0.0554 (1.00) |
0.962 (1.00) |
0.0795 (1.00) |
0.00371 (1.00) |
0.00697 (1.00) |
0.0876 (1.00) |
Amp Peak 20(20p11 23) |
0.234 (1.00) |
0.974 (1.00) |
0.2 (1.00) |
0.0127 (1.00) |
0.947 (1.00) |
0.0614 (1.00) |
0.00206 (1.00) |
0.00876 (1.00) |
0.121 (1.00) |
Amp Peak 21(20p11 21) |
0.453 (1.00) |
0.466 (1.00) |
0.165 (1.00) |
0.00494 (1.00) |
0.897 (1.00) |
0.272 (1.00) |
0.00305 (1.00) |
0.0131 (1.00) |
0.258 (1.00) |
Amp Peak 22(20q11 21) |
0.433 (1.00) |
0.474 (1.00) |
0.382 (1.00) |
7.66e-06 (0.00461) |
0.542 (1.00) |
0.0243 (1.00) |
0.0102 (1.00) |
0.000866 (0.493) |
0.562 (1.00) |
Amp Peak 23(20q12) |
0.365 (1.00) |
0.51 (1.00) |
0.324 (1.00) |
1.38e-06 (0.000832) |
0.678 (1.00) |
0.0293 (1.00) |
0.00474 (1.00) |
0.000579 (0.332) |
0.563 (1.00) |
Amp Peak 24(20q13 32) |
0.371 (1.00) |
0.537 (1.00) |
0.377 (1.00) |
4.8e-06 (0.00289) |
0.631 (1.00) |
0.0182 (1.00) |
0.00667 (1.00) |
0.000567 (0.326) |
0.565 (1.00) |
Del Peak 1(1p36 11) |
0.0209 (1.00) |
0.144 (1.00) |
0.54 (1.00) |
0.00362 (1.00) |
0.653 (1.00) |
0.00498 (1.00) |
0.000122 (0.0717) |
0.000885 (0.503) |
1 (1.00) |
Del Peak 2(1p33) |
0.00122 (0.684) |
0.89 (1.00) |
0.91 (1.00) |
0.132 (1.00) |
0.505 (1.00) |
0.00466 (1.00) |
0.00786 (1.00) |
0.0144 (1.00) |
0.572 (1.00) |
Del Peak 3(1p13 1) |
0.0503 (1.00) |
0.891 (1.00) |
0.496 (1.00) |
0.133 (1.00) |
0.541 (1.00) |
0.00105 (0.592) |
0.000797 (0.454) |
0.00869 (1.00) |
1 (1.00) |
Del Peak 4(1q43) |
0.488 (1.00) |
0.525 (1.00) |
0.875 (1.00) |
0.818 (1.00) |
0.3 (1.00) |
0.179 (1.00) |
0.077 (1.00) |
0.158 (1.00) |
0.287 (1.00) |
Del Peak 5(2q37 2) |
0.368 (1.00) |
0.447 (1.00) |
0.374 (1.00) |
0.748 (1.00) |
0.447 (1.00) |
0.825 (1.00) |
0.361 (1.00) |
0.454 (1.00) |
1 (1.00) |
Del Peak 6(3p26 1) |
0.000411 (0.238) |
0.346 (1.00) |
1 (1.00) |
0.146 (1.00) |
0.0583 (1.00) |
0.0186 (1.00) |
0.000457 (0.264) |
0.000553 (0.318) |
1 (1.00) |
Del Peak 7(3p14 2) |
0.426 (1.00) |
0.608 (1.00) |
0.371 (1.00) |
0.186 (1.00) |
0.189 (1.00) |
0.0486 (1.00) |
0.0569 (1.00) |
0.0529 (1.00) |
1 (1.00) |
Del Peak 8(3q26 31) |
0.452 (1.00) |
0.85 (1.00) |
1 (1.00) |
0.14 (1.00) |
0.0989 (1.00) |
0.595 (1.00) |
0.619 (1.00) |
0.168 (1.00) |
1 (1.00) |
Del Peak 9(4p16 2) |
0.00024 (0.141) |
0.609 (1.00) |
0.59 (1.00) |
0.036 (1.00) |
0.67 (1.00) |
0.000256 (0.15) |
0.000266 (0.155) |
0.000587 (0.335) |
0.0247 (1.00) |
Del Peak 10(4q22 1) |
0.009 (1.00) |
0.967 (1.00) |
0.593 (1.00) |
0.0174 (1.00) |
0.341 (1.00) |
0.00186 (1.00) |
0.118 (1.00) |
0.0169 (1.00) |
0.0279 (1.00) |
Del Peak 11(4q35 1) |
0.0437 (1.00) |
0.255 (1.00) |
0.249 (1.00) |
0.0871 (1.00) |
0.72 (1.00) |
0.00586 (1.00) |
0.221 (1.00) |
0.0424 (1.00) |
0.036 (1.00) |
Del Peak 12(5q11 2) |
0.0477 (1.00) |
0.0453 (1.00) |
0.408 (1.00) |
0.112 (1.00) |
0.899 (1.00) |
0.00319 (1.00) |
0.0574 (1.00) |
0.00895 (1.00) |
0.124 (1.00) |
Del Peak 13(5q21 3) |
0.0728 (1.00) |
0.0679 (1.00) |
0.743 (1.00) |
0.196 (1.00) |
0.976 (1.00) |
5.3e-05 (0.0315) |
0.0201 (1.00) |
0.000579 (0.332) |
0.0223 (1.00) |
Del Peak 14(5q23 1) |
0.129 (1.00) |
0.285 (1.00) |
0.311 (1.00) |
0.0983 (1.00) |
0.946 (1.00) |
0.00593 (1.00) |
0.0116 (1.00) |
0.0366 (1.00) |
0.017 (1.00) |
Del Peak 15(6p25 3) |
0.704 (1.00) |
0.0948 (1.00) |
0.0794 (1.00) |
0.516 (1.00) |
0.126 (1.00) |
0.932 (1.00) |
0.18 (1.00) |
0.825 (1.00) |
1 (1.00) |
Del Peak 16(6q26) |
0.0205 (1.00) |
0.928 (1.00) |
0.782 (1.00) |
1 (1.00) |
0.194 (1.00) |
0.0248 (1.00) |
0.0212 (1.00) |
0.11 (1.00) |
1 (1.00) |
Del Peak 17(7q31 1) |
0.978 (1.00) |
0.589 (1.00) |
0.36 (1.00) |
1 (1.00) |
0.571 (1.00) |
1 (1.00) |
0.498 (1.00) |
0.493 (1.00) |
1 (1.00) |
Del Peak 18(8p23 3) |
0.566 (1.00) |
0.251 (1.00) |
0.193 (1.00) |
0.0746 (1.00) |
0.165 (1.00) |
0.000318 (0.184) |
0.0225 (1.00) |
9.26e-05 (0.0548) |
0.572 (1.00) |
Del Peak 19(8p22) |
0.433 (1.00) |
0.104 (1.00) |
0.321 (1.00) |
0.0185 (1.00) |
0.222 (1.00) |
7.69e-06 (0.00462) |
0.00136 (0.763) |
2.17e-07 (0.000132) |
0.589 (1.00) |
Del Peak 20(8p11 22) |
0.412 (1.00) |
0.236 (1.00) |
0.803 (1.00) |
0.461 (1.00) |
0.342 (1.00) |
0.000914 (0.518) |
0.0887 (1.00) |
0.00266 (1.00) |
0.0973 (1.00) |
Del Peak 21(8p11 21) |
0.826 (1.00) |
0.377 (1.00) |
1 (1.00) |
0.633 (1.00) |
0.155 (1.00) |
0.000316 (0.184) |
0.00793 (1.00) |
0.00102 (0.577) |
0.282 (1.00) |
Del Peak 22(9p21 3) |
0.0248 (1.00) |
0.0603 (1.00) |
0.251 (1.00) |
0.202 (1.00) |
0.292 (1.00) |
0.144 (1.00) |
0.106 (1.00) |
0.399 (1.00) |
1 (1.00) |
Del Peak 23(10p15 3) |
0.847 (1.00) |
0.434 (1.00) |
0.791 (1.00) |
0.557 (1.00) |
0.856 (1.00) |
0.00164 (0.914) |
0.00231 (1.00) |
0.0011 (0.618) |
0.0717 (1.00) |
Del Peak 24(10q21 1) |
0.959 (1.00) |
0.0528 (1.00) |
0.388 (1.00) |
0.0995 (1.00) |
0.952 (1.00) |
0.00851 (1.00) |
0.0976 (1.00) |
0.0196 (1.00) |
0.102 (1.00) |
Del Peak 25(10q23 31) |
0.834 (1.00) |
0.0124 (1.00) |
0.483 (1.00) |
0.164 (1.00) |
0.503 (1.00) |
0.00523 (1.00) |
0.00814 (1.00) |
0.0221 (1.00) |
0.131 (1.00) |
Del Peak 26(10q25 2) |
0.313 (1.00) |
0.164 (1.00) |
0.907 (1.00) |
0.164 (1.00) |
0.227 (1.00) |
0.00365 (1.00) |
0.0681 (1.00) |
0.0169 (1.00) |
0.129 (1.00) |
Del Peak 27(12p13 2) |
0.384 (1.00) |
0.633 (1.00) |
0.338 (1.00) |
0.00188 (1.00) |
0.897 (1.00) |
0.0822 (1.00) |
0.166 (1.00) |
0.0971 (1.00) |
1 (1.00) |
Del Peak 28(13q14 13) |
0.312 (1.00) |
0.279 (1.00) |
1 (1.00) |
1 (1.00) |
0.719 (1.00) |
0.0629 (1.00) |
4.33e-05 (0.0258) |
0.835 (1.00) |
1 (1.00) |
Del Peak 29(14q32 11) |
0.353 (1.00) |
0.506 (1.00) |
0.674 (1.00) |
0.000917 (0.519) |
0.631 (1.00) |
0.0613 (1.00) |
0.0367 (1.00) |
0.00434 (1.00) |
0.554 (1.00) |
Del Peak 30(15q11 2) |
0.93 (1.00) |
0.852 (1.00) |
1 (1.00) |
0.0238 (1.00) |
0.912 (1.00) |
0.0115 (1.00) |
0.0635 (1.00) |
0.00321 (1.00) |
0.0575 (1.00) |
Del Peak 31(15q21 1) |
0.0937 (1.00) |
0.658 (1.00) |
0.919 (1.00) |
0.0488 (1.00) |
0.965 (1.00) |
0.0824 (1.00) |
0.0887 (1.00) |
0.0559 (1.00) |
0.0483 (1.00) |
Del Peak 32(15q22 33) |
0.255 (1.00) |
0.426 (1.00) |
0.918 (1.00) |
0.00592 (1.00) |
0.58 (1.00) |
0.0403 (1.00) |
0.0478 (1.00) |
0.0218 (1.00) |
0.0427 (1.00) |
Del Peak 33(16p13 3) |
0.00179 (0.996) |
0.426 (1.00) |
0.755 (1.00) |
1 (1.00) |
0.0362 (1.00) |
0.0647 (1.00) |
0.357 (1.00) |
0.163 (1.00) |
1 (1.00) |
Del Peak 34(16q23 1) |
0.00129 (0.722) |
0.288 (1.00) |
0.129 (1.00) |
0.261 (1.00) |
0.631 (1.00) |
0.384 (1.00) |
0.979 (1.00) |
0.896 (1.00) |
1 (1.00) |
Del Peak 35(17p12) |
0.334 (1.00) |
0.0108 (1.00) |
0.43 (1.00) |
3.38e-06 (0.00204) |
0.869 (1.00) |
2.64e-05 (0.0157) |
0.0165 (1.00) |
1.19e-06 (0.000721) |
0.257 (1.00) |
Del Peak 36(17q24 3) |
0.729 (1.00) |
0.51 (1.00) |
0.328 (1.00) |
1 (1.00) |
0.687 (1.00) |
0.00836 (1.00) |
0.253 (1.00) |
0.0329 (1.00) |
1 (1.00) |
Del Peak 37(18p11 31) |
0.869 (1.00) |
0.0199 (1.00) |
1 (1.00) |
8.39e-11 (5.13e-08) |
0.819 (1.00) |
0.0479 (1.00) |
0.00385 (1.00) |
0.00181 (1.00) |
0.251 (1.00) |
Del Peak 38(18q12 2) |
0.983 (1.00) |
0.0542 (1.00) |
0.421 (1.00) |
3.02e-10 (1.84e-07) |
0.838 (1.00) |
0.002 (1.00) |
0.0125 (1.00) |
0.000376 (0.218) |
0.277 (1.00) |
Del Peak 39(18q21 2) |
0.4 (1.00) |
0.0992 (1.00) |
0.127 (1.00) |
3.87e-09 (2.35e-06) |
0.805 (1.00) |
0.000112 (0.066) |
0.00624 (1.00) |
9.14e-06 (0.00548) |
0.299 (1.00) |
Del Peak 40(18q22 1) |
0.263 (1.00) |
0.176 (1.00) |
0.127 (1.00) |
4.48e-10 (2.73e-07) |
0.805 (1.00) |
0.000112 (0.066) |
0.00624 (1.00) |
2.02e-05 (0.0121) |
0.299 (1.00) |
Del Peak 41(19p13 3) |
0.367 (1.00) |
0.148 (1.00) |
0.67 (1.00) |
0.202 (1.00) |
0.956 (1.00) |
5.85e-05 (0.0347) |
0.0321 (1.00) |
0.00168 (0.932) |
0.36 (1.00) |
Del Peak 42(20p12 1) |
0.803 (1.00) |
0.439 (1.00) |
0.618 (1.00) |
0.137 (1.00) |
0.695 (1.00) |
0.553 (1.00) |
0.983 (1.00) |
0.419 (1.00) |
1 (1.00) |
Del Peak 43(21q11 2) |
0.468 (1.00) |
0.722 (1.00) |
1 (1.00) |
0.0101 (1.00) |
0.267 (1.00) |
0.0417 (1.00) |
0.344 (1.00) |
0.187 (1.00) |
0.219 (1.00) |
Del Peak 44(22q13 32) |
0.208 (1.00) |
0.701 (1.00) |
0.603 (1.00) |
0.00499 (1.00) |
0.732 (1.00) |
0.00257 (1.00) |
0.0348 (1.00) |
0.014 (1.00) |
1 (1.00) |
Cluster Labels | AMP PEAK 1(2Q33.1) MUTATED | AMP PEAK 1(2Q33.1) WILD-TYPE |
---|---|---|
Number of samples | 79 | 334 |
Cluster Labels | AMP PEAK 2(5P13.2) MUTATED | AMP PEAK 2(5P13.2) WILD-TYPE |
---|---|---|
Number of samples | 81 | 332 |
Cluster Labels | AMP PEAK 3(5Q22.3) MUTATED | AMP PEAK 3(5Q22.3) WILD-TYPE |
---|---|---|
Number of samples | 40 | 373 |
Cluster Labels | AMP PEAK 4(6P21.1) MUTATED | AMP PEAK 4(6P21.1) WILD-TYPE |
---|---|---|
Number of samples | 89 | 324 |
Cluster Labels | AMP PEAK 5(8P11.23) MUTATED | AMP PEAK 5(8P11.23) WILD-TYPE |
---|---|---|
Number of samples | 144 | 269 |
Cluster Labels | AMP PEAK 6(8P11.21) MUTATED | AMP PEAK 6(8P11.21) WILD-TYPE |
---|---|---|
Number of samples | 173 | 240 |
Cluster Labels | AMP PEAK 7(8Q12.1) MUTATED | AMP PEAK 7(8Q12.1) WILD-TYPE |
---|---|---|
Number of samples | 215 | 198 |
Cluster Labels | AMP PEAK 8(8Q24.21) MUTATED | AMP PEAK 8(8Q24.21) WILD-TYPE |
---|---|---|
Number of samples | 239 | 174 |
Cluster Labels | AMP PEAK 9(11P15.5) MUTATED | AMP PEAK 9(11P15.5) WILD-TYPE |
---|---|---|
Number of samples | 86 | 327 |
Cluster Labels | AMP PEAK 10(12P13.33) MUTATED | AMP PEAK 10(12P13.33) WILD-TYPE |
---|---|---|
Number of samples | 104 | 309 |
Cluster Labels | AMP PEAK 11(13Q12.13) MUTATED | AMP PEAK 11(13Q12.13) WILD-TYPE |
---|---|---|
Number of samples | 250 | 163 |
P value = 8.87e-07 (Fisher's exact test), Q value = 0.00054
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
AMP PEAK 11(13Q12.13) MUTATED | 233 | 16 |
AMP PEAK 11(13Q12.13) WILD-TYPE | 123 | 38 |
Cluster Labels | AMP PEAK 12(13Q22.1) MUTATED | AMP PEAK 12(13Q22.1) WILD-TYPE |
---|---|---|
Number of samples | 254 | 159 |
P value = 8.13e-06 (Fisher's exact test), Q value = 0.0049
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
AMP PEAK 12(13Q22.1) MUTATED | 235 | 18 |
AMP PEAK 12(13Q22.1) WILD-TYPE | 121 | 36 |
P value = 0.000315 (Fisher's exact test), Q value = 0.18
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
AMP PEAK 12(13Q22.1) MUTATED | 40 | 79 | 78 | 45 |
AMP PEAK 12(13Q22.1) WILD-TYPE | 27 | 78 | 38 | 11 |
Cluster Labels | AMP PEAK 13(16P11.2) MUTATED | AMP PEAK 13(16P11.2) WILD-TYPE |
---|---|---|
Number of samples | 116 | 297 |
P value = 0.000142 (Fisher's exact test), Q value = 0.083
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
AMP PEAK 13(16P11.2) MUTATED | 50 | 35 | 30 |
AMP PEAK 13(16P11.2) WILD-TYPE | 195 | 60 | 41 |
P value = 0.000162 (Fisher's exact test), Q value = 0.095
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
AMP PEAK 13(16P11.2) MUTATED | 12 | 30 | 48 | 18 |
AMP PEAK 13(16P11.2) WILD-TYPE | 55 | 127 | 68 | 38 |
Cluster Labels | AMP PEAK 14(16Q12.1) MUTATED | AMP PEAK 14(16Q12.1) WILD-TYPE |
---|---|---|
Number of samples | 102 | 311 |
P value = 0.000185 (Fisher's exact test), Q value = 0.11
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
AMP PEAK 14(16Q12.1) MUTATED | 43 | 33 | 26 |
AMP PEAK 14(16Q12.1) WILD-TYPE | 202 | 62 | 45 |
P value = 3e-05 (Fisher's exact test), Q value = 0.018
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
AMP PEAK 14(16Q12.1) MUTATED | 12 | 23 | 46 | 14 |
AMP PEAK 14(16Q12.1) WILD-TYPE | 55 | 134 | 70 | 42 |
Cluster Labels | AMP PEAK 15(17Q12) MUTATED | AMP PEAK 15(17Q12) WILD-TYPE |
---|---|---|
Number of samples | 101 | 312 |
Cluster Labels | AMP PEAK 16(17Q24.1) MUTATED | AMP PEAK 16(17Q24.1) WILD-TYPE |
---|---|---|
Number of samples | 92 | 321 |
Cluster Labels | AMP PEAK 17(19P13.2) MUTATED | AMP PEAK 17(19P13.2) WILD-TYPE |
---|---|---|
Number of samples | 65 | 348 |
Cluster Labels | AMP PEAK 18(19Q13.11) MUTATED | AMP PEAK 18(19Q13.11) WILD-TYPE |
---|---|---|
Number of samples | 83 | 330 |
Cluster Labels | AMP PEAK 19(20P12.3) MUTATED | AMP PEAK 19(20P12.3) WILD-TYPE |
---|---|---|
Number of samples | 184 | 229 |
Cluster Labels | AMP PEAK 20(20P11.23) MUTATED | AMP PEAK 20(20P11.23) WILD-TYPE |
---|---|---|
Number of samples | 205 | 208 |
Cluster Labels | AMP PEAK 21(20P11.21) MUTATED | AMP PEAK 21(20P11.21) WILD-TYPE |
---|---|---|
Number of samples | 230 | 183 |
Cluster Labels | AMP PEAK 22(20Q11.21) MUTATED | AMP PEAK 22(20Q11.21) WILD-TYPE |
---|---|---|
Number of samples | 296 | 117 |
P value = 7.66e-06 (Fisher's exact test), Q value = 0.0046
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
AMP PEAK 22(20Q11.21) MUTATED | 269 | 24 |
AMP PEAK 22(20Q11.21) WILD-TYPE | 87 | 30 |
Cluster Labels | AMP PEAK 23(20Q12) MUTATED | AMP PEAK 23(20Q12) WILD-TYPE |
---|---|---|
Number of samples | 297 | 116 |
P value = 1.38e-06 (Fisher's exact test), Q value = 0.00083
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
AMP PEAK 23(20Q12) MUTATED | 271 | 23 |
AMP PEAK 23(20Q12) WILD-TYPE | 85 | 31 |
Cluster Labels | AMP PEAK 24(20Q13.32) MUTATED | AMP PEAK 24(20Q13.32) WILD-TYPE |
---|---|---|
Number of samples | 300 | 113 |
P value = 4.8e-06 (Fisher's exact test), Q value = 0.0029
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
AMP PEAK 24(20Q13.32) MUTATED | 273 | 24 |
AMP PEAK 24(20Q13.32) WILD-TYPE | 83 | 30 |
Cluster Labels | DEL PEAK 1(1P36.11) MUTATED | DEL PEAK 1(1P36.11) WILD-TYPE |
---|---|---|
Number of samples | 150 | 263 |
P value = 0.000122 (Chi-square test), Q value = 0.072
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 312 | 49 | 7 | 1 | 36 |
DEL PEAK 1(1P36.11) MUTATED | 101 | 33 | 2 | 0 | 13 |
DEL PEAK 1(1P36.11) WILD-TYPE | 211 | 16 | 5 | 1 | 23 |
Cluster Labels | DEL PEAK 2(1P33) MUTATED | DEL PEAK 2(1P33) WILD-TYPE |
---|---|---|
Number of samples | 107 | 306 |
Cluster Labels | DEL PEAK 3(1P13.1) MUTATED | DEL PEAK 3(1P13.1) WILD-TYPE |
---|---|---|
Number of samples | 103 | 310 |
Cluster Labels | DEL PEAK 4(1Q43) MUTATED | DEL PEAK 4(1Q43) WILD-TYPE |
---|---|---|
Number of samples | 44 | 369 |
Cluster Labels | DEL PEAK 5(2Q37.2) MUTATED | DEL PEAK 5(2Q37.2) WILD-TYPE |
---|---|---|
Number of samples | 21 | 392 |
Cluster Labels | DEL PEAK 6(3P26.1) MUTATED | DEL PEAK 6(3P26.1) WILD-TYPE |
---|---|---|
Number of samples | 60 | 353 |
P value = 0.000411 (logrank test), Q value = 0.24
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 319 | 49 | 0.1 - 135.5 (7.7) |
DEL PEAK 6(3P26.1) MUTATED | 43 | 8 | 0.2 - 16.9 (5.0) |
DEL PEAK 6(3P26.1) WILD-TYPE | 276 | 41 | 0.1 - 135.5 (8.2) |
Cluster Labels | DEL PEAK 7(3P14.2) MUTATED | DEL PEAK 7(3P14.2) WILD-TYPE |
---|---|---|
Number of samples | 75 | 338 |
Cluster Labels | DEL PEAK 8(3Q26.31) MUTATED | DEL PEAK 8(3Q26.31) WILD-TYPE |
---|---|---|
Number of samples | 39 | 374 |
Cluster Labels | DEL PEAK 9(4P16.2) MUTATED | DEL PEAK 9(4P16.2) WILD-TYPE |
---|---|---|
Number of samples | 121 | 292 |
P value = 0.00024 (logrank test), Q value = 0.14
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 319 | 49 | 0.1 - 135.5 (7.7) |
DEL PEAK 9(4P16.2) MUTATED | 89 | 20 | 0.2 - 87.8 (7.6) |
DEL PEAK 9(4P16.2) WILD-TYPE | 230 | 29 | 0.1 - 135.5 (8.0) |
P value = 0.000256 (Fisher's exact test), Q value = 0.15
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 9(4P16.2) MUTATED | 54 | 34 | 32 |
DEL PEAK 9(4P16.2) WILD-TYPE | 191 | 61 | 39 |
P value = 0.000266 (Chi-square test), Q value = 0.16
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 312 | 49 | 7 | 1 | 36 |
DEL PEAK 9(4P16.2) MUTATED | 75 | 27 | 3 | 0 | 12 |
DEL PEAK 9(4P16.2) WILD-TYPE | 237 | 22 | 4 | 1 | 24 |
Cluster Labels | DEL PEAK 10(4Q22.1) MUTATED | DEL PEAK 10(4Q22.1) WILD-TYPE |
---|---|---|
Number of samples | 126 | 287 |
Cluster Labels | DEL PEAK 11(4Q35.1) MUTATED | DEL PEAK 11(4Q35.1) WILD-TYPE |
---|---|---|
Number of samples | 137 | 276 |
Cluster Labels | DEL PEAK 12(5Q11.2) MUTATED | DEL PEAK 12(5Q11.2) WILD-TYPE |
---|---|---|
Number of samples | 91 | 322 |
Cluster Labels | DEL PEAK 13(5Q21.3) MUTATED | DEL PEAK 13(5Q21.3) WILD-TYPE |
---|---|---|
Number of samples | 117 | 296 |
P value = 5.3e-05 (Fisher's exact test), Q value = 0.031
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 13(5Q21.3) MUTATED | 50 | 34 | 32 |
DEL PEAK 13(5Q21.3) WILD-TYPE | 195 | 61 | 39 |
Cluster Labels | DEL PEAK 14(5Q23.1) MUTATED | DEL PEAK 14(5Q23.1) WILD-TYPE |
---|---|---|
Number of samples | 107 | 306 |
Cluster Labels | DEL PEAK 15(6P25.3) MUTATED | DEL PEAK 15(6P25.3) WILD-TYPE |
---|---|---|
Number of samples | 54 | 359 |
Cluster Labels | DEL PEAK 16(6Q26) MUTATED | DEL PEAK 16(6Q26) WILD-TYPE |
---|---|---|
Number of samples | 60 | 353 |
Cluster Labels | DEL PEAK 17(7Q31.1) MUTATED | DEL PEAK 17(7Q31.1) WILD-TYPE |
---|---|---|
Number of samples | 11 | 402 |
Cluster Labels | DEL PEAK 18(8P23.3) MUTATED | DEL PEAK 18(8P23.3) WILD-TYPE |
---|---|---|
Number of samples | 171 | 242 |
P value = 0.000318 (Fisher's exact test), Q value = 0.18
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 18(8P23.3) MUTATED | 82 | 46 | 41 |
DEL PEAK 18(8P23.3) WILD-TYPE | 163 | 49 | 30 |
P value = 9.26e-05 (Fisher's exact test), Q value = 0.055
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
DEL PEAK 18(8P23.3) MUTATED | 24 | 48 | 59 | 34 |
DEL PEAK 18(8P23.3) WILD-TYPE | 43 | 109 | 57 | 22 |
Cluster Labels | DEL PEAK 19(8P22) MUTATED | DEL PEAK 19(8P22) WILD-TYPE |
---|---|---|
Number of samples | 185 | 228 |
P value = 7.69e-06 (Fisher's exact test), Q value = 0.0046
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 19(8P22) MUTATED | 87 | 49 | 47 |
DEL PEAK 19(8P22) WILD-TYPE | 158 | 46 | 24 |
P value = 2.17e-07 (Fisher's exact test), Q value = 0.00013
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
DEL PEAK 19(8P22) MUTATED | 24 | 50 | 66 | 39 |
DEL PEAK 19(8P22) WILD-TYPE | 43 | 107 | 50 | 17 |
Cluster Labels | DEL PEAK 20(8P11.22) MUTATED | DEL PEAK 20(8P11.22) WILD-TYPE |
---|---|---|
Number of samples | 80 | 333 |
Cluster Labels | DEL PEAK 21(8P11.21) MUTATED | DEL PEAK 21(8P11.21) WILD-TYPE |
---|---|---|
Number of samples | 43 | 370 |
P value = 0.000316 (Fisher's exact test), Q value = 0.18
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 21(8P11.21) MUTATED | 14 | 14 | 15 |
DEL PEAK 21(8P11.21) WILD-TYPE | 231 | 81 | 56 |
Cluster Labels | DEL PEAK 22(9P21.3) MUTATED | DEL PEAK 22(9P21.3) WILD-TYPE |
---|---|---|
Number of samples | 56 | 357 |
Cluster Labels | DEL PEAK 23(10P15.3) MUTATED | DEL PEAK 23(10P15.3) WILD-TYPE |
---|---|---|
Number of samples | 68 | 345 |
Cluster Labels | DEL PEAK 24(10Q21.1) MUTATED | DEL PEAK 24(10Q21.1) WILD-TYPE |
---|---|---|
Number of samples | 82 | 331 |
Cluster Labels | DEL PEAK 25(10Q23.31) MUTATED | DEL PEAK 25(10Q23.31) WILD-TYPE |
---|---|---|
Number of samples | 94 | 319 |
Cluster Labels | DEL PEAK 26(10Q25.2) MUTATED | DEL PEAK 26(10Q25.2) WILD-TYPE |
---|---|---|
Number of samples | 93 | 320 |
Cluster Labels | DEL PEAK 27(12P13.2) MUTATED | DEL PEAK 27(12P13.2) WILD-TYPE |
---|---|---|
Number of samples | 44 | 369 |
Cluster Labels | DEL PEAK 28(13Q14.13) MUTATED | DEL PEAK 28(13Q14.13) WILD-TYPE |
---|---|---|
Number of samples | 18 | 395 |
P value = 4.33e-05 (Chi-square test), Q value = 0.026
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 312 | 49 | 7 | 1 | 36 |
DEL PEAK 28(13Q14.13) MUTATED | 12 | 1 | 0 | 1 | 2 |
DEL PEAK 28(13Q14.13) WILD-TYPE | 300 | 48 | 7 | 0 | 34 |
Cluster Labels | DEL PEAK 29(14Q32.11) MUTATED | DEL PEAK 29(14Q32.11) WILD-TYPE |
---|---|---|
Number of samples | 133 | 280 |
Cluster Labels | DEL PEAK 30(15Q11.2) MUTATED | DEL PEAK 30(15Q11.2) WILD-TYPE |
---|---|---|
Number of samples | 160 | 253 |
Cluster Labels | DEL PEAK 31(15Q21.1) MUTATED | DEL PEAK 31(15Q21.1) WILD-TYPE |
---|---|---|
Number of samples | 151 | 262 |
Cluster Labels | DEL PEAK 32(15Q22.33) MUTATED | DEL PEAK 32(15Q22.33) WILD-TYPE |
---|---|---|
Number of samples | 145 | 268 |
Cluster Labels | DEL PEAK 33(16P13.3) MUTATED | DEL PEAK 33(16P13.3) WILD-TYPE |
---|---|---|
Number of samples | 45 | 368 |
Cluster Labels | DEL PEAK 34(16Q23.1) MUTATED | DEL PEAK 34(16Q23.1) WILD-TYPE |
---|---|---|
Number of samples | 49 | 364 |
Cluster Labels | DEL PEAK 35(17P12) MUTATED | DEL PEAK 35(17P12) WILD-TYPE |
---|---|---|
Number of samples | 229 | 184 |
P value = 3.38e-06 (Fisher's exact test), Q value = 0.002
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
DEL PEAK 35(17P12) MUTATED | 213 | 14 |
DEL PEAK 35(17P12) WILD-TYPE | 143 | 40 |
P value = 2.64e-05 (Fisher's exact test), Q value = 0.016
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 35(17P12) MUTATED | 113 | 63 | 51 |
DEL PEAK 35(17P12) WILD-TYPE | 132 | 32 | 20 |
P value = 1.19e-06 (Fisher's exact test), Q value = 0.00072
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
DEL PEAK 35(17P12) MUTATED | 34 | 64 | 80 | 41 |
DEL PEAK 35(17P12) WILD-TYPE | 33 | 93 | 36 | 15 |
Cluster Labels | DEL PEAK 36(17Q24.3) MUTATED | DEL PEAK 36(17Q24.3) WILD-TYPE |
---|---|---|
Number of samples | 59 | 354 |
Cluster Labels | DEL PEAK 37(18P11.31) MUTATED | DEL PEAK 37(18P11.31) WILD-TYPE |
---|---|---|
Number of samples | 220 | 193 |
P value = 8.39e-11 (Fisher's exact test), Q value = 5.1e-08
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
DEL PEAK 37(18P11.31) MUTATED | 211 | 7 |
DEL PEAK 37(18P11.31) WILD-TYPE | 145 | 47 |
Cluster Labels | DEL PEAK 38(18Q12.2) MUTATED | DEL PEAK 38(18Q12.2) WILD-TYPE |
---|---|---|
Number of samples | 247 | 166 |
P value = 3.02e-10 (Fisher's exact test), Q value = 1.8e-07
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
DEL PEAK 38(18Q12.2) MUTATED | 235 | 11 |
DEL PEAK 38(18Q12.2) WILD-TYPE | 121 | 43 |
P value = 0.000376 (Fisher's exact test), Q value = 0.22
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
DEL PEAK 38(18Q12.2) MUTATED | 34 | 78 | 78 | 43 |
DEL PEAK 38(18Q12.2) WILD-TYPE | 33 | 79 | 38 | 13 |
Cluster Labels | DEL PEAK 39(18Q21.2) MUTATED | DEL PEAK 39(18Q21.2) WILD-TYPE |
---|---|---|
Number of samples | 260 | 153 |
P value = 3.87e-09 (Fisher's exact test), Q value = 2.4e-06
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
DEL PEAK 39(18Q21.2) MUTATED | 245 | 14 |
DEL PEAK 39(18Q21.2) WILD-TYPE | 111 | 40 |
P value = 0.000112 (Fisher's exact test), Q value = 0.066
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 39(18Q21.2) MUTATED | 134 | 68 | 56 |
DEL PEAK 39(18Q21.2) WILD-TYPE | 111 | 27 | 15 |
P value = 9.14e-06 (Fisher's exact test), Q value = 0.0055
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
DEL PEAK 39(18Q21.2) MUTATED | 36 | 81 | 83 | 47 |
DEL PEAK 39(18Q21.2) WILD-TYPE | 31 | 76 | 33 | 9 |
Cluster Labels | DEL PEAK 40(18Q22.1) MUTATED | DEL PEAK 40(18Q22.1) WILD-TYPE |
---|---|---|
Number of samples | 260 | 153 |
P value = 4.48e-10 (Fisher's exact test), Q value = 2.7e-07
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 356 | 54 |
DEL PEAK 40(18Q22.1) MUTATED | 246 | 13 |
DEL PEAK 40(18Q22.1) WILD-TYPE | 110 | 41 |
P value = 0.000112 (Fisher's exact test), Q value = 0.066
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 40(18Q22.1) MUTATED | 134 | 68 | 56 |
DEL PEAK 40(18Q22.1) WILD-TYPE | 111 | 27 | 15 |
P value = 2.02e-05 (Fisher's exact test), Q value = 0.012
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 67 | 157 | 116 | 56 |
DEL PEAK 40(18Q22.1) MUTATED | 36 | 82 | 82 | 47 |
DEL PEAK 40(18Q22.1) WILD-TYPE | 31 | 75 | 34 | 9 |
Cluster Labels | DEL PEAK 41(19P13.3) MUTATED | DEL PEAK 41(19P13.3) WILD-TYPE |
---|---|---|
Number of samples | 57 | 356 |
P value = 5.85e-05 (Fisher's exact test), Q value = 0.035
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 245 | 95 | 71 |
DEL PEAK 41(19P13.3) MUTATED | 22 | 13 | 22 |
DEL PEAK 41(19P13.3) WILD-TYPE | 223 | 82 | 49 |
Cluster Labels | DEL PEAK 42(20P12.1) MUTATED | DEL PEAK 42(20P12.1) WILD-TYPE |
---|---|---|
Number of samples | 79 | 334 |
Cluster Labels | DEL PEAK 43(21Q11.2) MUTATED | DEL PEAK 43(21Q11.2) WILD-TYPE |
---|---|---|
Number of samples | 125 | 288 |
Cluster Labels | DEL PEAK 44(22Q13.32) MUTATED | DEL PEAK 44(22Q13.32) WILD-TYPE |
---|---|---|
Number of samples | 138 | 275 |
-
Cluster data file = all_lesions.conf_99.cnv.cluster.txt
-
Clinical data file = COAD-TP.clin.merged.picked.txt
-
Number of patients = 413
-
Number of clustering approaches = 68
-
Number of selected clinical features = 9
-
Exclude small clusters that include fewer than K patients, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between two tumor subtypes using 't.test' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.