Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.168 -9999.0 0.0 -0.554 14.0 14.0 IHH -0.011 0.134 -9999.0 0.0 -0.375 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.001 0.091 -9999.0 0.0 -0.211 27.0 27.0 LRPAP1 0.026 0.03 -9999.0 0.0 -0.376 1.0 1.0 dorsoventral neural tube patterning 0.002 0.09 0.21 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.021 0.166 -9999.0 0.0 -0.378 25.0 25.0 SMO -0.037 0.165 -9999.0 0.0 -0.381 29.0 29.0 AKT1 -0.037 0.162 -9999.0 0.0 -0.418 20.0 20.0 ARRB2 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.03 0.047 -9999.0 0.0 -0.376 2.0 2.0 ADRBK1 0.028 0.031 -9999.0 0.0 -0.376 1.0 1.0 heart looping -0.037 0.162 -9999.0 0.0 -0.376 29.0 29.0 STIL -0.023 0.117 0.178 9.0 -0.292 19.0 28.0 DHH N/PTCH2 0.029 0.078 0.168 2.0 -0.267 11.0 13.0 DHH N/PTCH1 -0.004 0.119 -9999.0 0.0 -0.248 33.0 33.0 PIK3CA 0.028 0.03 -9999.0 0.0 -0.376 1.0 1.0 DHH 0.024 0.062 -9999.0 0.0 -0.376 4.0 4.0 PTHLH -0.062 0.24 -9999.0 0.0 -0.812 14.0 14.0 determination of left/right symmetry -0.037 0.162 -9999.0 0.0 -0.376 29.0 29.0 PIK3R1 0.027 0.03 -9999.0 0.0 -0.376 1.0 1.0 skeletal system development -0.061 0.237 -9999.0 0.0 -0.803 14.0 14.0 IHH N/Hhip -0.006 0.127 -9999.0 0.0 -0.297 27.0 27.0 DHH N/Hhip 0.016 0.095 -9999.0 0.0 -0.268 18.0 18.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.162 -9999.0 0.0 -0.376 29.0 29.0 pancreas development -0.0 0.108 -9999.0 0.0 -0.375 14.0 14.0 HHAT 0.022 0.052 -9999.0 0.0 -0.376 3.0 3.0 PI3K 0.039 0.034 -9999.0 0.0 -0.268 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.005 0.14 -9999.0 0.0 -0.376 22.0 22.0 somite specification -0.037 0.162 -9999.0 0.0 -0.376 29.0 29.0 SHH Np/Cholesterol/PTCH1 -0.017 0.118 0.185 2.0 -0.26 30.0 32.0 SHH Np/Cholesterol/PTCH2 0.01 0.065 -9999.0 0.0 -0.217 13.0 13.0 SHH Np/Cholesterol/Megalin 0.017 0.052 0.2 1.0 -0.206 8.0 9.0 SHH -0.023 0.049 -9999.0 0.0 -0.267 7.0 7.0 catabolic process -0.018 0.119 -9999.0 0.0 -0.284 29.0 29.0 SMO/Vitamin D3 -0.028 0.145 0.217 4.0 -0.327 30.0 34.0 SHH Np/Cholesterol/Hhip -0.001 0.082 -9999.0 0.0 -0.233 19.0 19.0 LRP2 0.032 0.025 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.031 0.139 -9999.0 0.0 -0.349 22.0 22.0 SHH Np/Cholesterol/BOC 0.018 0.05 -9999.0 0.0 -0.204 8.0 8.0 SHH Np/Cholesterol/CDO 0.015 0.05 -9999.0 0.0 -0.202 9.0 9.0 mesenchymal cell differentiation 0.001 0.082 0.231 19.0 -9999.0 0.0 19.0 mol:Vitamin D3 -0.011 0.126 0.204 11.0 -0.264 29.0 40.0 IHH N/PTCH2 0.005 0.112 0.178 1.0 -0.281 21.0 22.0 CDON 0.028 0.031 -9999.0 0.0 -0.376 1.0 1.0 IHH N/PTCH1 -0.007 0.125 -9999.0 0.0 -0.286 29.0 29.0 Megalin/LRPAP1 0.042 0.031 -9999.0 0.0 -0.27 1.0 1.0 PTCH2 0.017 0.08 -9999.0 0.0 -0.376 7.0 7.0 SHH Np/Cholesterol 0.005 0.044 -9999.0 0.0 -0.198 8.0 8.0 PTCH1 -0.018 0.12 -9999.0 0.0 -0.285 29.0 29.0 HHIP -0.0 0.108 -9999.0 0.0 -0.376 14.0 14.0