Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.02 0.213 -9999.0 0.0 -0.662 12.0 12.0 IHH 0.019 0.072 -9999.0 0.0 -0.789 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.121 0.197 -9999.0 0.0 -0.409 46.0 46.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.121 0.195 0.406 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 0.048 0.104 -9999.0 0.0 -0.705 1.0 1.0 SMO 0.041 0.11 -9999.0 0.0 -0.753 1.0 1.0 AKT1 0.052 0.054 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.042 0.109 -9999.0 0.0 -0.737 1.0 1.0 STIL -0.044 0.212 -9999.0 0.0 -0.608 9.0 9.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.023 0.081 -9999.0 0.0 -0.7 1.0 1.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.028 0.205 -9999.0 0.0 -1.561 1.0 1.0 determination of left/right symmetry 0.042 0.109 -9999.0 0.0 -0.737 1.0 1.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.029 0.202 -9999.0 0.0 -1.506 1.0 1.0 IHH N/Hhip -0.089 0.229 -9999.0 0.0 -0.517 34.0 34.0 DHH N/Hhip -0.101 0.191 -9999.0 0.0 -0.462 34.0 34.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.042 0.109 -9999.0 0.0 -0.737 1.0 1.0 pancreas development -0.126 0.269 -9999.0 0.0 -0.634 34.0 34.0 HHAT -0.051 0.198 -9999.0 0.0 -0.636 16.0 16.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.128 0.279 -9999.0 0.0 -0.664 33.0 33.0 somite specification 0.042 0.109 -9999.0 0.0 -0.737 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.007 0.15 -9999.0 0.0 -0.543 4.0 4.0 SHH Np/Cholesterol/PTCH2 -0.042 0.116 -9999.0 0.0 -0.432 2.0 2.0 SHH Np/Cholesterol/Megalin -0.042 0.116 -9999.0 0.0 -0.432 2.0 2.0 SHH -0.027 0.162 -9999.0 0.0 -0.472 18.0 18.0 catabolic process 0.036 0.114 -9999.0 0.0 -0.774 1.0 1.0 SMO/Vitamin D3 0.018 0.149 -9999.0 0.0 -0.56 3.0 3.0 SHH Np/Cholesterol/Hhip -0.119 0.203 -9999.0 0.0 -0.419 44.0 44.0 LRP2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.048 0.111 -9999.0 0.0 -0.524 3.0 3.0 SHH Np/Cholesterol/BOC -0.042 0.116 -9999.0 0.0 -0.36 18.0 18.0 SHH Np/Cholesterol/CDO -0.042 0.116 -9999.0 0.0 -0.432 2.0 2.0 mesenchymal cell differentiation 0.118 0.201 0.416 44.0 -9999.0 0.0 44.0 mol:Vitamin D3 0.011 0.152 -9999.0 0.0 -0.544 4.0 4.0 IHH N/PTCH2 0.028 0.045 -9999.0 0.0 -0.507 1.0 1.0 CDON 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.035 0.114 -9999.0 0.0 -0.787 1.0 1.0 Megalin/LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.043 0.119 -9999.0 0.0 -0.372 18.0 18.0 PTCH1 0.036 0.114 -9999.0 0.0 -0.778 1.0 1.0 HHIP -0.126 0.27 -9999.0 0.0 -0.636 34.0 34.0