PLK1 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations regulation of centriole-centriole cohesion -0.009 0.025 -9999.0 0.0 -0.116 1.0 1.0 BUB1B -0.011 0.065 -9999.0 0.0 -0.139 8.0 8.0 PLK1 0.019 0.032 0.08 1.0 -9999.0 0.0 1.0 PLK1S1 0.008 0.017 0.043 1.0 -9999.0 0.0 1.0 KIF2A 0.016 0.028 -9999.0 0.0 -9999.0 0.0 0.0 regulation of mitotic centrosome separation 0.019 0.032 0.08 1.0 -9999.0 0.0 1.0 GOLGA2 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Hec1/SPC24 0.026 0.033 -9999.0 0.0 -0.176 1.0 1.0 WEE1 0.014 0.074 -9999.0 0.0 -0.412 3.0 3.0 cytokinesis 0.016 0.055 -9999.0 0.0 -9999.0 0.0 0.0 PP2A-alpha B56 0.031 0.132 -9999.0 0.0 -0.626 5.0 5.0 AURKA 0.028 0.032 0.111 1.0 -9999.0 0.0 1.0 PICH/PLK1 -0.075 0.139 0.186 7.0 -0.279 32.0 39.0 CENPE 0.011 0.041 -9999.0 0.0 -0.162 4.0 4.0 RhoA/GTP 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of microtubule depolymerization 0.016 0.027 -9999.0 0.0 -9999.0 0.0 0.0 PPP2CA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FZR1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TPX2 0.044 0.052 0.127 23.0 -9999.0 0.0 23.0 PAK1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SPC24 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CLSPN 0.011 0.051 -9999.0 0.0 -0.216 6.0 6.0 GORASP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 metaphase 0.0 0.003 0.018 2.0 -0.011 1.0 3.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NLP 0.008 0.017 0.043 1.0 -9999.0 0.0 1.0 G2 phase of mitotic cell cycle 0.001 0.004 0.018 2.0 -9999.0 0.0 2.0 STAG2 0.029 0.041 -9999.0 0.0 -0.317 2.0 2.0 GRASP65/GM130/RAB1/GTP 0.011 0.062 -9999.0 0.0 -0.499 2.0 2.0 spindle elongation 0.019 0.032 0.08 1.0 -9999.0 0.0 1.0 ODF2 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BUB1 -0.011 0.13 -9999.0 0.0 -0.679 5.0 5.0 TPT1 0.028 0.041 -9999.0 0.0 -0.191 2.0 2.0 CDC25C 0.018 0.037 -9999.0 0.0 -0.236 2.0 2.0 CDC25B -0.097 0.164 -9999.0 0.0 -0.319 52.0 52.0 SGOL1 0.009 0.025 0.116 1.0 -9999.0 0.0 1.0 RHOA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CCNB1/CDK1 -0.031 0.092 -9999.0 0.0 -0.213 13.0 13.0 CDC14B 0.011 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC20 0.023 0.057 -9999.0 0.0 -0.317 4.0 4.0 PLK1/PBIP1 0.005 0.048 -9999.0 0.0 -0.153 8.0 8.0 mitosis -0.002 0.003 -9999.0 0.0 -9999.0 0.0 0.0 FBXO5 0.002 0.046 -9999.0 0.0 -0.142 5.0 5.0 CDC2 -0.001 0.006 0.01 14.0 -0.011 14.0 28.0 NDC80 0.024 0.031 -9999.0 0.0 -0.317 1.0 1.0 metaphase plate congression -0.003 0.079 -9999.0 0.0 -0.223 16.0 16.0 ERCC6L -0.071 0.133 0.176 7.0 -0.274 29.0 36.0 NLP/gamma Tubulin 0.009 0.017 0.087 1.0 -9999.0 0.0 1.0 microtubule cytoskeleton organization 0.028 0.041 -9999.0 0.0 -0.19 2.0 2.0 G2/M transition DNA damage checkpoint -0.0 0.003 0.016 4.0 -9999.0 0.0 4.0 PPP1R12A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 interphase -0.0 0.003 0.016 4.0 -9999.0 0.0 4.0 PLK1/PRC1-2 0.03 0.079 -9999.0 0.0 -0.211 8.0 8.0 GRASP65/GM130/RAB1/GTP/PLK1 0.067 0.029 -9999.0 0.0 -9999.0 0.0 0.0 RAB1A 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 prophase -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Aurora A/BORA 0.025 0.034 0.075 23.0 -9999.0 0.0 23.0 mitotic prometaphase 0.001 0.006 0.018 16.0 -9999.0 0.0 16.0 proteasomal ubiquitin-dependent protein catabolic process 0.029 0.054 -9999.0 0.0 -0.387 2.0 2.0 microtubule-based process 0.019 0.066 -9999.0 0.0 -0.171 12.0 12.0 Golgi organization 0.019 0.032 0.08 1.0 -9999.0 0.0 1.0 Cohesin/SA2 0.032 0.031 -9999.0 0.0 -9999.0 0.0 0.0 PPP1CB/MYPT1 0.05 0.008 -9999.0 0.0 -9999.0 0.0 0.0 KIF20A -0.002 0.106 -9999.0 0.0 -0.317 15.0 15.0 APC/C/CDC20 0.032 0.043 -9999.0 0.0 -0.168 3.0 3.0 PPP2R1A 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 chromosome segregation 0.005 0.047 -9999.0 0.0 -0.151 8.0 8.0 PRC1 0.022 0.057 -9999.0 0.0 -0.317 4.0 4.0 ECT2 -0.085 0.087 0.232 1.0 -0.16 62.0 63.0 C13orf34 0.019 0.029 0.073 2.0 -9999.0 0.0 2.0 NUDC -0.003 0.079 -9999.0 0.0 -0.224 16.0 16.0 regulation of attachment of spindle microtubules to kinetochore -0.01 0.065 -9999.0 0.0 -0.138 8.0 8.0 spindle assembly 0.014 0.027 0.132 1.0 -9999.0 0.0 1.0 spindle stabilization 0.008 0.017 0.043 1.0 -9999.0 0.0 1.0 APC/C/HCDH1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MKLP2/PLK1 0.019 0.067 -9999.0 0.0 -0.172 12.0 12.0 CCNB1 -0.028 0.133 -9999.0 0.0 -0.316 26.0 26.0 PPP1CB 0.035 0.001 -9999.0 0.0 -9999.0 0.0 0.0 BTRC 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK2 0.03 0.026 -9999.0 0.0 -9999.0 0.0 0.0 TUBG1 0.018 0.018 -9999.0 0.0 -9999.0 0.0 0.0 G2/M transition of mitotic cell cycle -0.027 0.101 0.174 14.0 -0.214 11.0 25.0 MLF1IP -0.009 0.063 -9999.0 0.0 -0.22 12.0 12.0 INCENP 0.028 0.041 -9999.0 0.0 -0.317 2.0 2.0