Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MET/RANBP9 -0.075 0.131 -9999.0 0.0 -0.217 67.0 67.0 CRKL 0.02 0.098 -9999.0 0.0 -0.475 3.0 3.0 mol:PIP3 0.004 0.06 0.45 2.0 -9999.0 0.0 2.0 AKT1 0.001 0.045 0.306 2.0 -9999.0 0.0 2.0 PTK2B 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.021 0.096 0.304 1.0 -0.453 3.0 4.0 RANBP10 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET/SHIP2 -0.05 0.121 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K5 0.033 0.097 -9999.0 0.0 -0.567 2.0 2.0 HGF/MET/CIN85/CBL/ENDOPHILINS -0.041 0.133 -9999.0 0.0 -0.395 4.0 4.0 AP1 -0.035 0.106 -9999.0 0.0 -0.316 10.0 10.0 mol:SU11274 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis -0.098 0.29 -9999.0 0.0 -0.76 23.0 23.0 STAT3 (dimer) 0.014 0.061 0.23 2.0 -9999.0 0.0 2.0 GAB1/CRKL/SHP2/PI3K 0.067 0.095 -9999.0 0.0 -0.487 2.0 2.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CBL/CRK 0.039 0.098 -9999.0 0.0 -0.51 2.0 2.0 PTPN11 0.031 0.029 -9999.0 0.0 -0.317 1.0 1.0 GO:0007205 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.018 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PTEN 0.024 0.063 -9999.0 0.0 -0.509 2.0 2.0 ELK1 -0.045 0.11 0.287 6.0 -9999.0 0.0 6.0 mol:SU5416 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHP2/GRB2/SOS1GAB1 -0.005 0.049 -9999.0 0.0 -0.342 1.0 1.0 PAK1 0.0 0.043 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET/RANBP10 -0.05 0.121 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.016 0.07 -9999.0 0.0 -0.407 1.0 1.0 DOCK1 0.018 0.097 -9999.0 0.0 -0.504 2.0 2.0 GAB1 0.01 0.094 -9999.0 0.0 -0.502 3.0 3.0 CRK 0.019 0.097 -9999.0 0.0 -0.475 3.0 3.0 mol:PHA665752 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.007 0.053 -9999.0 0.0 -9999.0 0.0 0.0 JUN 0.021 0.063 -9999.0 0.0 -0.317 5.0 5.0 EntrezGene:200958 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.048 0.057 -9999.0 0.0 -0.218 1.0 1.0 PIK3R1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 cell morphogenesis 0.059 0.099 0.279 5.0 -9999.0 0.0 5.0 GRB2/SHC -0.021 0.077 -9999.0 0.0 -9999.0 0.0 0.0 FOS 0.003 0.113 -9999.0 0.0 -0.461 8.0 8.0 GLMN 0.002 0.013 -9999.0 0.0 -0.158 1.0 1.0 cell motility -0.045 0.109 0.286 6.0 -9999.0 0.0 6.0 HGF/MET/MUC20 -0.06 0.11 -9999.0 0.0 -0.179 68.0 68.0 cell migration -0.021 0.076 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CBL 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MET/RANBP10 -0.075 0.131 -9999.0 0.0 -0.217 68.0 68.0 HGF/MET/Paxillin/FAK1/FAK12/RasGAP -0.014 0.062 -9999.0 0.0 -0.282 1.0 1.0 MET/MUC20 -0.087 0.119 -9999.0 0.0 -0.216 68.0 68.0 RAP1B 0.022 0.093 0.292 1.0 -0.48 2.0 3.0 RAP1A 0.019 0.091 0.292 1.0 -0.48 2.0 3.0 HGF/MET/RANBP9 -0.05 0.121 -9999.0 0.0 -9999.0 0.0 0.0 RAF1 0.015 0.066 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 0.014 0.061 0.231 2.0 -9999.0 0.0 2.0 cell proliferation 0.032 0.073 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 -0.021 0.058 -9999.0 0.0 -0.322 3.0 3.0 MAPK3 -0.058 0.125 0.696 2.0 -9999.0 0.0 2.0 MAPK1 -0.024 0.196 0.663 9.0 -9999.0 0.0 9.0 RANBP9 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 0.037 0.104 -9999.0 0.0 -0.503 2.0 2.0 SRC 0.018 0.068 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.023 0.078 -9999.0 0.0 -9999.0 0.0 0.0 MET/Glomulin -0.101 0.109 -9999.0 0.0 -0.208 71.0 71.0 SOS1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 0.016 0.066 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.129 0.173 -9999.0 0.0 -0.317 68.0 68.0 MAP4K1 0.033 0.105 -9999.0 0.0 -0.621 2.0 2.0 PTK2 0.027 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K2 0.015 0.066 -9999.0 0.0 -9999.0 0.0 0.0 BAD 0.0 0.043 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 0.022 0.088 -9999.0 0.0 -0.511 2.0 2.0 SHP2/GRB2/SOS1/GAB1 0.034 0.098 -9999.0 0.0 -0.476 2.0 2.0 INPPL1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PXN 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 SH3KBP1 0.019 0.088 -9999.0 0.0 -0.509 4.0 4.0 HGS -0.042 0.055 -9999.0 0.0 -0.203 1.0 1.0 PLCgamma1/PKC 0.014 0.012 -9999.0 0.0 -9999.0 0.0 0.0 HGF 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RASA1 0.031 0.029 -9999.0 0.0 -0.317 1.0 1.0 NCK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTPRJ 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK/PLCgamma1 0.004 0.056 -9999.0 0.0 -9999.0 0.0 0.0 PDPK1 0.001 0.051 0.351 2.0 -9999.0 0.0 2.0 HGF/MET/SHIP -0.06 0.11 -9999.0 0.0 -0.179 68.0 68.0