HIV-1 Nef: Negative effector of Fas and TNF-alpha Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BAG4 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Caspase 8 (4 units) -0.008 0.143 -9999.0 0.0 -0.404 10.0 10.0 NEF -0.019 0.058 -9999.0 0.0 -9999.0 0.0 0.0 NFKBIA 0.027 0.028 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 0.009 0.102 -9999.0 0.0 -0.556 4.0 4.0 CYCS -0.026 0.149 -9999.0 0.0 -0.455 9.0 9.0 RIPK1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CD247 -0.019 0.151 -9999.0 0.0 -0.617 7.0 7.0 MAP2K7 -0.001 0.159 -9999.0 0.0 -0.791 3.0 3.0 protein ubiquitination 0.036 0.056 0.222 1.0 -0.309 1.0 2.0 CRADD 0.03 0.045 -9999.0 0.0 -0.509 1.0 1.0 DAXX 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FAS -0.016 0.153 -9999.0 0.0 -0.509 13.0 13.0 BID -0.039 0.151 0.198 4.0 -0.458 10.0 14.0 NF-kappa-B/RelA/I kappa B alpha 0.055 0.069 -9999.0 0.0 -0.28 4.0 4.0 TRADD 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K5 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CFLAR 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FADD 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NF-kappa-B/RelA/I kappa B alpha/ubiquitin 0.055 0.069 -9999.0 0.0 -0.282 4.0 4.0 MAPK8 -0.0 0.146 -9999.0 0.0 -0.712 3.0 3.0 APAF1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 TRAF1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 TRAF2 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG -0.03 0.159 0.207 5.0 -0.344 24.0 29.0 TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD 0.042 0.065 -9999.0 0.0 -0.383 2.0 2.0 CHUK 0.039 0.053 0.227 1.0 -0.334 1.0 2.0 FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0.06 0.107 -9999.0 0.0 -0.269 13.0 13.0 TCRz/NEF -0.033 0.158 -9999.0 0.0 -0.372 24.0 24.0 TNF 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 FASLG -0.079 0.247 -9999.0 0.0 -0.628 24.0 24.0 NFKB1 0.03 0.027 -9999.0 0.0 -9999.0 0.0 0.0 TNFR1A/BAG4/TNF-alpha 0.059 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CASP6 0.018 0.143 -9999.0 0.0 -0.659 3.0 3.0 CASP7 -0.053 0.189 -9999.0 0.0 -0.489 14.0 14.0 RELA 0.03 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CASP2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CASP3 -0.018 0.158 -9999.0 0.0 -0.531 8.0 8.0 TNFRSF1A 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TNFR1A/BAG4 0.043 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP9 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K14 0.042 0.067 -9999.0 0.0 -0.38 1.0 1.0 APAF-1/Caspase 9 -0.011 0.136 -9999.0 0.0 -0.471 4.0 4.0 BCL2 -0.098 0.159 -9999.0 0.0 -0.61 4.0 4.0