EPHB forward signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Ephrin A5/EPHB2 0.032 0.05 -9999.0 0.0 -0.246 4.0 4.0 cell-cell adhesion 0.048 0.075 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B/EPHB2/RasGAP 0.051 0.065 -9999.0 0.0 -0.263 2.0 2.0 ITSN1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B1/EPHB3 0.027 0.067 -9999.0 0.0 -0.204 11.0 11.0 Ephrin B1/EPHB1 -0.031 0.106 -9999.0 0.0 -0.179 50.0 50.0 HRAS/GDP -0.041 0.108 -9999.0 0.0 -0.429 2.0 2.0 Ephrin B/EPHB1/GRB7 0.011 0.099 -9999.0 0.0 -0.256 1.0 1.0 Endophilin/SYNJ1 0.061 0.082 -9999.0 0.0 -0.253 1.0 1.0 KRAS 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B/EPHB1/Src 0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 endothelial cell migration 0.012 0.08 -9999.0 0.0 -0.266 1.0 1.0 GRB2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GRB7 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PAK1 0.068 0.085 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RRAS 0.069 0.086 -9999.0 0.0 -0.257 1.0 1.0 DNM1 0.024 0.057 -9999.0 0.0 -0.317 4.0 4.0 cell-cell signaling 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.009 0.095 -9999.0 0.0 -0.313 1.0 1.0 lamellipodium assembly -0.048 0.075 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B/EPHB1/Src/p52 SHC/GRB2 0.021 0.057 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EPHB2 0.022 0.06 -9999.0 0.0 -0.381 3.0 3.0 EPHB3 0.005 0.103 -9999.0 0.0 -0.352 11.0 11.0 EPHB1 -0.085 0.166 -9999.0 0.0 -0.317 50.0 50.0 EPHB4 -0.037 0.138 -9999.0 0.0 -0.317 29.0 29.0 mol:GDP -0.026 0.11 0.245 3.0 -0.446 2.0 5.0 Ephrin B/EPHB2 0.04 0.053 -9999.0 0.0 -0.262 2.0 2.0 Ephrin B/EPHB3 0.032 0.068 -9999.0 0.0 -0.264 3.0 3.0 JNK cascade -0.041 0.104 0.353 2.0 -0.311 5.0 7.0 Ephrin B/EPHB1 -0.002 0.09 -9999.0 0.0 -0.255 1.0 1.0 RAP1/GDP -0.01 0.126 0.331 2.0 -0.397 2.0 4.0 EFNB2 0.019 0.046 -9999.0 0.0 -0.509 1.0 1.0 EFNB3 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EFNB1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B2/EPHB1-2 -0.014 0.093 -9999.0 0.0 -0.285 2.0 2.0 RAP1B 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.009 0.09 -9999.0 0.0 -0.311 1.0 1.0 Rap1/GTP -0.018 0.071 -9999.0 0.0 -9999.0 0.0 0.0 axon guidance 0.032 0.05 -9999.0 0.0 -0.245 4.0 4.0 MAPK3 0.019 0.062 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.021 0.054 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.027 0.112 0.299 1.0 -0.413 2.0 3.0 actin cytoskeleton reorganization -0.051 0.075 -9999.0 0.0 -0.3 2.0 2.0 CDC42/GDP -0.016 0.124 0.332 2.0 -0.413 2.0 4.0 PI3K 0.015 0.083 -9999.0 0.0 -0.268 1.0 1.0 EFNA5 0.029 0.045 -9999.0 0.0 -0.509 1.0 1.0 Ephrin B2/EPHB4 -0.005 0.081 -9999.0 0.0 -0.185 23.0 23.0 Ephrin B/EPHB2/Intersectin/N-WASP 0.018 0.047 -9999.0 0.0 -0.315 1.0 1.0 CDC42 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP -0.021 0.068 -9999.0 0.0 -9999.0 0.0 0.0 PTK2 0.111 0.223 0.59 26.0 -9999.0 0.0 26.0 MAP4K4 -0.041 0.105 0.354 2.0 -0.314 5.0 7.0 SRC 0.019 0.017 -9999.0 0.0 -9999.0 0.0 0.0 KALRN 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Intersectin/N-WASP 0.043 0.037 -9999.0 0.0 -0.369 1.0 1.0 neuron projection morphogenesis -0.009 0.108 0.288 6.0 -9999.0 0.0 6.0 MAP2K1 0.018 0.051 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.029 0.045 -9999.0 0.0 -0.509 1.0 1.0 Ephrin B1/EPHB1-2/NCK1 -0.007 0.121 -9999.0 0.0 -0.304 3.0 3.0 cell migration 0.05 0.089 0.239 1.0 -9999.0 0.0 1.0 NRAS 0.027 0.041 -9999.0 0.0 -0.317 2.0 2.0 SYNJ1 0.062 0.083 -9999.0 0.0 -0.257 1.0 1.0 PXN 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 TF 0.054 0.083 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GTP -0.006 0.085 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B1/EPHB1-2 -0.019 0.111 -9999.0 0.0 -0.303 3.0 3.0 cell adhesion mediated by integrin -0.061 0.099 0.253 1.0 -0.205 43.0 44.0 RAC1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.005 0.089 -9999.0 0.0 -9999.0 0.0 0.0 RAC1-CDC42/GTP -0.032 0.078 -9999.0 0.0 -0.352 2.0 2.0 RASA1 0.031 0.029 -9999.0 0.0 -0.317 1.0 1.0 RAC1-CDC42/GDP -0.02 0.112 0.299 1.0 -0.397 2.0 3.0 ruffle organization -0.0 0.136 0.364 7.0 -9999.0 0.0 7.0 NCK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 receptor internalization 0.052 0.085 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B/EPHB2/KALRN 0.052 0.063 -9999.0 0.0 -0.263 2.0 2.0 ROCK1 0.006 0.054 -9999.0 0.0 -0.284 2.0 2.0 RAS family/GDP -0.05 0.071 -9999.0 0.0 -0.349 1.0 1.0 Rac1/GTP -0.047 0.081 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B/EPHB1/Src/Paxillin 0.009 0.041 -9999.0 0.0 -9999.0 0.0 0.0