Role of Calcineurin-dependent NFAT signaling in lymphocytes Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 0.02 0.017 -9999.0 0.0 -9999.0 0.0 0.0 NFATC1 -0.019 0.138 0.25 1.0 -0.39 11.0 12.0 NFATC2 0.043 0.047 0.16 1.0 -9999.0 0.0 1.0 NFATC3 0.015 0.006 -9999.0 0.0 -9999.0 0.0 0.0 YWHAE 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Calcineurin A alpha-beta B1/CABIN1 0.005 0.068 -9999.0 0.0 -0.265 3.0 3.0 Exportin 1/Ran/NUP214 0.068 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:DAG 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CABIN1/MEF2D/CaM/Ca2+/CAMK IV 0.042 0.072 -9999.0 0.0 -9999.0 0.0 0.0 BCL2/BAX -0.146 0.179 -9999.0 0.0 -0.367 54.0 54.0 CaM/Ca2+/Calcineurin A alpha-beta B1 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CaM/Ca2+ 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BAX 0.031 0.029 -9999.0 0.0 -0.317 1.0 1.0 MAPK14 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 BAD 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CABIN1/MEF2D 0.021 0.071 -9999.0 0.0 -0.252 3.0 3.0 Calcineurin A alpha-beta B1/BCL2 -0.171 0.253 -9999.0 0.0 -0.509 53.0 53.0 FKBP8 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 activation-induced cell death of T cells -0.021 0.07 0.25 3.0 -9999.0 0.0 3.0 KPNB1 0.023 0.057 -9999.0 0.0 -0.317 4.0 4.0 KPNA2 0.011 0.084 -9999.0 0.0 -0.317 9.0 9.0 XPO1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SFN 0.026 0.045 -9999.0 0.0 -0.509 1.0 1.0 MAP3K8 0.001 0.103 -9999.0 0.0 -0.316 14.0 14.0 NFAT4/CK1 alpha 0.033 0.028 -9999.0 0.0 -9999.0 0.0 0.0 MEF2D/NFAT1/Cbp/p300 0.092 0.054 -9999.0 0.0 -9999.0 0.0 0.0 CABIN1 0.004 0.068 -9999.0 0.0 -0.267 3.0 3.0 CALM1 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RAN 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CAMK4 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.026 0.063 -9999.0 0.0 -0.509 2.0 2.0 YWHAH 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Calcineurin A alpha-beta B1/AKAP79/PKA 0.027 0.083 -9999.0 0.0 -0.369 6.0 6.0 YWHAB 0.018 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAPK9 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 YWHAG 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 FKBP1A 0.026 0.014 -9999.0 0.0 -9999.0 0.0 0.0 NFAT1-c-4/YWHAQ 0.012 0.135 -9999.0 0.0 -0.37 7.0 7.0 PRKCH 0.023 0.063 -9999.0 0.0 -0.509 2.0 2.0 CABIN1/Cbp/p300 0.047 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CASP3 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIM1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Calcineurin A alpha-beta B1/FKBP12/FK506 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis -0.016 0.05 -9999.0 0.0 -9999.0 0.0 0.0 14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 0.038 0.045 -9999.0 0.0 -9999.0 0.0 0.0 PRKCB -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCE 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 JNK2/NFAT4 0.029 0.024 -9999.0 0.0 -9999.0 0.0 0.0 BAD/BCL-XL 0.029 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PRKCD 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NUP214 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PRKCG 0.024 0.057 -9999.0 0.0 -0.317 4.0 4.0 PRKCQ 0.024 0.057 -9999.0 0.0 -0.317 4.0 4.0 FKBP38/BCL2 -0.143 0.18 -9999.0 0.0 -0.369 53.0 53.0 EP300 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PRKCB1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CSNK2A1 0.026 0.014 -9999.0 0.0 -9999.0 0.0 0.0 NFATc/JNK1 -0.002 0.138 -9999.0 0.0 -0.386 8.0 8.0 CaM/Ca2+/FKBP38 0.04 0.017 -9999.0 0.0 -9999.0 0.0 0.0 FKBP12/FK506 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CSNK1A1 0.018 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CaM/Ca2+/CAMK IV 0.039 0.017 -9999.0 0.0 -9999.0 0.0 0.0 NFATc/ERK1 -0.007 0.138 -9999.0 0.0 -0.396 7.0 7.0 CABIN1/YWHAQ/CaM/Ca2+/CAMK IV 0.042 0.073 -9999.0 0.0 -9999.0 0.0 0.0 NR4A1 0.059 0.053 -9999.0 0.0 -9999.0 0.0 0.0 GSK3B 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive T cell selection 0.015 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NFAT1/CK1 alpha 0.037 0.036 -9999.0 0.0 -9999.0 0.0 0.0 RCH1/ KPNB1 0.026 0.084 -9999.0 0.0 -0.272 10.0 10.0 YWHAQ 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AKAP5 0.008 0.107 -9999.0 0.0 -0.509 6.0 6.0 MEF2D 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:FK506 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YWHAZ 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 NFATc/p38 alpha -0.004 0.139 0.256 1.0 -0.368 11.0 12.0 CREBBP 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BCL2 -0.171 0.253 -9999.0 0.0 -0.509 53.0 53.0