		Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	103 (66%)	52	0.086514	1	0.068291	1	0.1013	1	0.16745	1	0.59808	1	0.071476	1	0.52787	1	1	1	1	1
BRAF	20 (13%)	135	7.2743e-06	0.00728	5.2866e-07	0.00053	8.4985e-05	0.0846	0.60786	1	0.43829	1	7.2161e-08	7.25e-05	1.1522e-07	0.000116	0.14533	1	1	1
FBXW7	29 (19%)	126	0.20063	1	0.20781	1	0.00082466	0.803	0.02263	1	0.02396	1	0.0076406	1	0.026123	1	0.58342	1	0.65747	1
KRAS	58 (37%)	97	0.014747	1	0.00021464	0.212	0.14993	1	0.5215	1	0.2983	1	9.4441e-08	9.48e-05	0.76475	1	1	1	0.61348	1
NRAS	15 (10%)	140	0.12389	1	0.42026	1	0.531	1	0.36824	1	0.43829	1	0.395	1	0.52843	1	1	1	1	1
PIK3CA	26 (17%)	129	0.30289	1	0.65516	1	0.01783	1	0.0080375	1	0.084083	1	0.0043536	1	0.53244	1	1	1	0.59239	1
TP53	75 (48%)	80	0.0069105	1	0.0086149	1	1.0799e-09	1.09e-06	0.24888	1	0.89381	1	0.0032457	1	0.066859	1	0.36629	1	0.80713	1
SMAD4	18 (12%)	137	0.20595	1	0.010407	1	0.010006	1	0.53944	1	0.12524	1	0.025412	1	0.4212	1	1	1	1	1
FAM123B	19 (12%)	136	0.11566	1	0.036423	1	0.019023	1	0.31326	1	0.51896	1	0.029593	1	0.050717	1	0.49751	1	0.49751	1
TTN	69 (45%)	86	0.0041575	1	0.014182	1	0.0010973	1	0.16325	1	0.96407	1	0.13992	1	0.00030795	0.303	0.65532	1	0.79319	1
WBSCR17	17 (11%)	138	0.50937	1	0.56829	1	0.38775	1	0.19041	1	0.32124	1	0.7041	1	0.27635	1	0.10888	1	0.10888	1
ACVR1B	13 (8%)	142	0.26938	1	0.50683	1	0.00744	1	0.16559	1	0.049616	1	0.11463	1	0.0094242	1	1	1	0.38574	1
TNFRSF10C	6 (4%)	149	0.42505	1	0.55574	1	0.081139	1	0.66261	1	0.16162	1	0.78341	1	0.65581	1	1	1	1	1
SMAD2	10 (6%)	145	0.10684	1	0.0037431	1	0.033333	1	1	1	0.56529	1	0.041301	1	0.040403	1	0.2827	1	1	1
MAP2K4	9 (6%)	146	0.48508	1	0.27866	1	0.051238	1	0.40536	1	0.75677	1	0.061141	1	0.34381	1	1	1	0.2549	1
PCBP1	4 (3%)	151	0.38093	1	0.57423	1	0.48567	1	NA	NA	NA	NA	0.18329	1	0.75277	1	1	1	1	1
FAT4	29 (19%)	126	0.006305	1	0.011517	1	0.00017245	0.171	0.178	1	0.74797	1	0.048722	1	0.0049218	1	0.24089	1	0.021801	1
LRP1B	30 (19%)	125	0.0035592	1	0.0018701	1	0.0011237	1	0.60786	1	0.86687	1	0.00054669	0.536	0.0035903	1	1	1	0.0078875	1
NRXN1	17 (11%)	138	0.33372	1	0.45759	1	0.013449	1	1	1	1	1	0.089833	1	0.10913	1	1	1	0.45495	1
GRIA1	14 (9%)	141	0.14623	1	0.23092	1	0.32931	1	NA	NA	NA	NA	0.073843	1	0.082945	1	1	1	0.00041107	0.404
SDK1	25 (16%)	130	0.0044016	1	0.0013979	1	0.30989	1	1	1	0.90756	1	0.013253	1	0.027116	1	1	1	0.57467	1
SOX9	9 (6%)	146	0.26283	1	0.1805	1	0.5849	1	0.69733	1	1	1	0.4447	1	0.25708	1	1	1	1	1
DMD	27 (17%)	128	0.014643	1	0.011939	1	0.008545	1	0.47396	1	0.17368	1	0.038066	1	0.018819	1	1	1	0.09984	1
CNTN6	15 (10%)	140	0.13346	1	0.23524	1	0.32931	1	0.33963	1	0.67396	1	0.81225	1	0.12112	1	1	1	0.36117	1
GABRA5	8 (5%)	147	0.66237	1	0.89688	1	1	1	NA	NA	NA	NA	0.6991	1	0.43183	1	0.19671	1	0.19671	1
OR2M4	8 (5%)	147	0.0061537	1	0.43549	1	0.077134	1	0.33963	1	0.67396	1	0.071306	1	0.17272	1	1	1	0.2549	1
OR6N1	8 (5%)	147	0.00012603	0.125	0.040446	1	0.009709	1	NA	NA	NA	NA	0.01836	1	0.008732	1	0.22624	1	1	1
PCDH9	16 (10%)	139	0.46179	1	0.79854	1	0.35408	1	0.2383	1	0.75677	1	0.17386	1	0.84528	1	1	1	0.40955	1
TXNDC3	10 (6%)	145	0.10038	1	0.29817	1	0.054831	1	0.45703	1	0.050016	1	0.16477	1	0.18162	1	1	1	0.2827	1
MGC26647	7 (5%)	148	0.27296	1	0.94721	1	0.88724	1	0.39466	1	0.67396	1	0.52058	1	0.48556	1	1	1	0.16628	1
FAM22F	8 (5%)	147	1	1	0.14728	1	0.90578	1	0.86897	1	0.75677	1	0.53443	1	0.53528	1	1	1	1	1
ACVR2A	8 (5%)	147	0.021251	1	0.46004	1	0.098006	1	0.14846	1	0.2459	1	0.20241	1	0.090272	1	1	1	0.2549	1
TCF7L2	11 (7%)	144	0.48508	1	0.55651	1	0.087525	1	0.60378	1	1	1	0.19843	1	0.38906	1	1	1	0.2827	1
AFF2	15 (10%)	140	0.010631	1	0.12067	1	0.64821	1	0.30419	1	0.1274	1	0.034093	1	0.90921	1	0.40955	1	0.40955	1
CNBD1	6 (4%)	149	0.49533	1	0.55574	1	0.31246	1	NA	NA	NA	NA	0.089689	1	0.25831	1	1	1	0.19671	1
OTOL1	7 (5%)	148	0.38093	1	1	1	1	1	NA	NA	NA	NA	0.70691	1	1	1	1	1	0.22624	1
KCNA4	10 (6%)	145	0.094309	1	0.1596	1	0.12251	1	0.050074	1	0.17937	1	0.2556	1	0.0043116	1	1	1	1	1
ISL1	8 (5%)	147	0.10162	1	0.47083	1	0.75626	1	1	1	1	1	0.47692	1	0.13951	1	1	1	0.2549	1
MGC42105	10 (6%)	145	0.0061442	1	0.17722	1	0.16218	1	0.14616	1	0.074813	1	0.12188	1	0.18196	1	1	1	1	1
ACOT4	3 (2%)	152	0.67371	1	0.093962	1	0.73592	1	NA	NA	NA	NA	1	1	0.66533	1	1	1	1	1
CDH11	13 (8%)	142	0.10546	1	0.34858	1	0.25835	1	1	1	1	1	0.37446	1	0.24855	1	0.33582	1	1	1
ATM	21 (14%)	134	0.14831	1	0.35102	1	0.0020755	1	0.23684	1	1	1	0.24121	1	0.051346	1	1	1	0.07021	1
TPTE	11 (7%)	144	0.10401	1	0.1593	1	0.12922	1	0.77988	1	1	1	0.006139	1	0.12096	1	1	1	0.30967	1
BTNL8	3 (2%)	152	0.34149	1	0.093962	1	0.31707	1	0.14846	1	1	1	0.48317	1	0.66533	1	1	1	1	1
KLHL4	12 (8%)	143	0.0093925	1	0.31223	1	0.0061785	1	0.059117	1	1	1	0.024562	1	0.019423	1	0.2827	1	0.2827	1
ROBO1	14 (9%)	141	0.12761	1	0.10745	1	0.086645	1	0.017983	1	0.58996	1	0.21043	1	0.086277	1	1	1	0.38574	1
GGT1	3 (2%)	152	NA	NA	NA	NA	0.31707	1	NA	NA	NA	NA	0.48317	1	0.66533	1	1	1	1	1
FLG	26 (17%)	129	0.00016191	0.16	0.0076463	1	0.00027044	0.267	0.068539	1	0.65266	1	0.00074635	0.728	9.6908e-05	0.0963	1	1	0.60952	1
PCDHB2	13 (8%)	142	0.022688	1	0.032736	1	0.091203	1	1	1	1	1	0.12661	1	0.025501	1	1	1	0.33582	1
POSTN	11 (7%)	144	0.30195	1	0.67409	1	0.075931	1	0.33804	1	0.56529	1	0.51043	1	0.18799	1	1	1	1	1
OR51V1	9 (6%)	146	0.0055879	1	0.01735	1	0.0043555	1	0.27214	1	1	1	0.0073551	1	0.00015762	0.156	1	1	0.2827	1
GRIK3	14 (9%)	141	0.40541	1	0.16863	1	0.47617	1	0.51789	1	0.61836	1	0.27696	1	0.69653	1	1	1	1	1
LRRN3	9 (6%)	146	0.021251	1	0.22384	1	0.28789	1	0.050074	1	0.17937	1	0.0029416	1	0.0089043	1	0.22624	1	1	1
PRDM9	11 (7%)	144	0.0020044	1	0.67409	1	0.12922	1	0.22613	1	0.86687	1	0.054851	1	0.29264	1	1	1	0.33582	1
ADAM29	9 (6%)	146	0.49844	1	0.38714	1	0.2679	1	NA	NA	NA	NA	0.81057	1	0.41299	1	1	1	1	1
KIAA1486	9 (6%)	146	0.8171	1	0.7999	1	0.46946	1	0.60378	1	1	1	0.78349	1	0.66214	1	1	1	0.2549	1
PSG8	8 (5%)	147	0.42505	1	0.20388	1	0.19659	1	NA	NA	NA	NA	0.77987	1	1	1	0.22624	1	0.1022	1
NCKAP5	13 (8%)	142	0.14263	1	0.098102	1	0.14301	1	0.010348	1	1	1	0.3064	1	0.0043878	1	1	1	0.36117	1
C8B	9 (6%)	146	0.23	1	0.23263	1	0.85262	1	0.33804	1	1	1	0.6032	1	0.41299	1	1	1	1	1
DNAH5	28 (18%)	127	8.2319e-06	0.00823	0.002318	1	0.01336	1	0.15853	1	0.51773	1	0.0010429	1	0.0017595	1	0.58452	1	0.64205	1
CASP8	10 (6%)	145	0.00060119	0.587	4.002e-05	0.0399	0.0017353	1	0.33963	1	1	1	0.00059837	0.585	5.7512e-05	0.0573	1	1	0.2549	1
CCDC160	5 (3%)	150	0.56738	1	0.79076	1	0.50583	1	NA	NA	NA	NA	0.63539	1	0.35622	1	1	1	0.16628	1
DCAF4L2	9 (6%)	146	0.072102	1	0.01735	1	0.23243	1	NA	NA	NA	NA	0.12188	1	0.0045625	1	1	1	1	1
DKK2	5 (3%)	150	0.0078765	1	0.10149	1	0.50583	1	0.40536	1	0.44626	1	0.039262	1	0.19978	1	1	1	1	1
EPHA3	13 (8%)	142	0.0046864	1	0.10745	1	0.25835	1	0.10545	1	0.53707	1	0.12661	1	0.0094242	1	1	1	0.36117	1
ERBB4	14 (9%)	141	0.10686	1	0.44232	1	0.053794	1	1	1	0.52112	1	0.038487	1	0.35021	1	1	1	0.36117	1
GUCY1A3	10 (6%)	145	0.12927	1	0.12472	1	0.22681	1	NA	NA	NA	NA	0.010684	1	0.019555	1	1	1	0.2827	1
IFT80	7 (5%)	148	0.56738	1	0.27404	1	0.13528	1	NA	NA	NA	NA	0.37734	1	0.25831	1	0.19671	1	1	1
INHBA	7 (5%)	148	0.11233	1	0.40132	1	0.31246	1	NA	NA	NA	NA	0.36776	1	0.0027011	1	0.16628	1	0.16628	1
KLK2	3 (2%)	152	1	1	0.487	1	0.73592	1	NA	NA	NA	NA	0.74147	1	0.66533	1	1	1	NA	NA
LPPR4	11 (7%)	144	0.10546	1	0.033166	1	0.28319	1	0.067292	1	0.75677	1	0.38828	1	0.12096	1	1	1	1	1
OR7C1	6 (4%)	149	0.02895	1	0.14542	1	0.74406	1	NA	NA	NA	NA	0.62118	1	0.25831	1	1	1	0.19671	1
SCN7A	12 (8%)	143	0.00045131	0.443	0.043482	1	0.16076	1	0.56202	1	0.86687	1	0.012395	1	0.041934	1	1	1	0.33582	1
TGFBR2	7 (5%)	148	0.02516	1	0.21273	1	0.06093	1	NA	NA	NA	NA	0.35089	1	0.0027011	1	0.19671	1	0.19671	1
TRPS1	13 (8%)	142	0.0066082	1	0.32995	1	0.00054694	0.536	NA	NA	NA	NA	0.0035168	1	0.0093688	1	1	1	0.33582	1
OR8J1	4 (3%)	151	0.42539	1	0.37117	1	0.61855	1	NA	NA	NA	NA	0.1234	1	0.75277	1	1	1	0.10266	1
RIMS2	12 (8%)	143	0.012095	1	0.12349	1	0.042877	1	0.60378	1	1	1	0.0083737	1	0.041934	1	1	1	0.33582	1
SFMBT2	12 (8%)	143	0.4811	1	0.34055	1	0.21014	1	0.58727	1	1	1	0.41429	1	0.019423	1	1	1	0.36117	1
IL18R1	8 (5%)	147	0.28533	1	0.43549	1	0.29391	1	0.60378	1	1	1	0.47692	1	0.43183	1	1	1	0.2549	1
PCDH17	14 (9%)	141	0.053496	1	0.90844	1	0.67283	1	0.45703	1	0.2459	1	0.26078	1	0.52843	1	1	1	0.36117	1
FLRT2	11 (7%)	144	0.695	1	0.90844	1	0.36706	1	0.091018	1	1	1	0.56181	1	1	1	1	1	0.2827	1
ZC3H13	17 (11%)	138	0.0031224	1	0.0009529	0.926	0.0068161	1	0.37076	1	0.35277	1	0.074474	1	1.7994e-05	0.018	1	1	0.40955	1
PTEN	4 (3%)	151	0.13209	1	0.30567	1	0.13154	1	NA	NA	NA	NA	0.01689	1	0.39548	1	1	1	0.13494	1
ZFHX4	17 (11%)	138	0.39815	1	0.62279	1	0.45486	1	0.75433	1	1	1	0.39263	1	0.096387	1	1	1	0.045233	1
NRXN3	15 (10%)	140	0.0011948	1	0.02601	1	0.050618	1	0.91088	1	0.26725	1	0.015428	1	0.054205	1	1	1	0.38574	1
LIFR	13 (8%)	142	0.16961	1	0.80618	1	0.35501	1	0.77988	1	0.56529	1	0.49819	1	0.24855	1	1	1	0.025341	1
ZNF429	7 (5%)	148	0.36411	1	0.59942	1	0.88724	1	NA	NA	NA	NA	0.031592	1	0.25831	1	1	1	0.19671	1
OR2M2	6 (4%)	149	0.36411	1	0.73452	1	0.5737	1	NA	NA	NA	NA	0.74072	1	0.81455	1	1	1	0.16628	1
TMEM132D	15 (10%)	140	4.9156e-05	0.049	0.00082921	0.807	0.027151	1	0.37076	1	1	1	0.017484	1	0.030631	1	1	1	1	1
SAT1	4 (3%)	151	0.0039422	1	0.27404	1	0.61855	1	0.45703	1	0.10112	1	0.44729	1	0.39548	1	1	1	1	1
CDH18	10 (6%)	145	0.021576	1	0.25597	1	0.047141	1	0.085687	1	0.53707	1	0.53187	1	0.18162	1	1	1	0.2827	1
P2RY10	6 (4%)	149	0.61095	1	0.48195	1	0.74406	1	NA	NA	NA	NA	0.4217	1	0.25831	1	1	1	1	1
SYT16	6 (4%)	149	0.037008	1	0.31348	1	0.059649	1	0.081035	1	0.56529	1	0.06534	1	0.33381	1	0.19671	1	1	1
DKK4	4 (3%)	151	0.070358	1	0.27404	1	0.18793	1	NA	NA	NA	NA	0.26415	1	0.39548	1	1	1	1	1
NALCN	14 (9%)	141	0.009583	1	0.18232	1	0.012928	1	1	1	0.81954	1	0.053522	1	0.025501	1	1	1	0.36117	1
SULT1C4	3 (2%)	152	0.011899	1	0.11982	1	0.068363	1	NA	NA	NA	NA	NA	NA	NA	NA	1	1	NA	NA
UMOD	7 (5%)	148	0.097852	1	0.20643	1	0.16601	1	0.45703	1	0.56529	1	0.19172	1	0.19994	1	1	1	0.13494	1
CPXCR1	6 (4%)	149	0.070358	1	0.40442	1	0.5737	1	NA	NA	NA	NA	0.83251	1	0.25831	1	0.19671	1	0.014141	1
PDZRN4	12 (8%)	143	0.005685	1	0.01036	1	0.0059339	1	0.60378	1	1	1	0.000357	0.351	0.0011118	1	0.30967	1	0.30967	1
USP17L2	7 (5%)	148	0.35742	1	0.46004	1	0.74406	1	0.66261	1	0.75677	1	0.78003	1	0.24641	1	0.19671	1	0.19671	1
ESR1	11 (7%)	144	0.26938	1	0.16371	1	0.10536	1	0.45703	1	0.56529	1	0.57546	1	0.039746	1	1	1	0.2827	1
FAM5C	10 (6%)	145	0.16986	1	0.59239	1	0.047141	1	0.032502	1	0.56529	1	0.13322	1	0.29563	1	0.2827	1	0.2827	1
MIER3	10 (6%)	145	0.0010002	0.971	0.024562	1	0.0030329	1	1	1	1	1	0.015511	1	0.011097	1	1	1	0.30967	1
NLRP5	10 (6%)	145	0.025465	1	0.83632	1	0.16218	1	NA	NA	NA	NA	0.023067	1	0.79272	1	1	1	0.2549	1
OR6T1	6 (4%)	149	0.29151	1	0.82833	1	0.74406	1	NA	NA	NA	NA	0.83251	1	0.65581	1	0.16628	1	1	1
PCDH10	14 (9%)	141	0.14623	1	0.23524	1	0.23663	1	0.64718	1	1	1	0.060797	1	0.0099783	1	1	1	0.36117	1
PCDHB5	12 (8%)	143	0.091603	1	0.46701	1	0.16076	1	0.22613	1	0.13449	1	0.37446	1	0.53018	1	1	1	0.30967	1
TRPC6	8 (5%)	147	0.11022	1	0.94721	1	0.3495	1	NA	NA	NA	NA	0.25379	1	0.36126	1	1	1	0.19671	1
RHOA	4 (3%)	151	NA	NA	NA	NA	0.61855	1	NA	NA	NA	NA	0.44729	1	0.035555	1	0.13494	1	1	1
SYNE1	37 (24%)	118	0.00017771	0.176	0.00078787	0.768	0.00028853	0.284	0.41815	1	0.74436	1	0.0031823	1	0.0013625	1	1	1	0.18111	1
CYTL1	4 (3%)	151	0.38093	1	0.33804	1	0.61855	1	NA	NA	NA	NA	0.20852	1	1	1	1	1	0.13494	1
CHRM2	8 (5%)	147	0.8171	1	0.46004	1	0.13832	1	0.83491	1	1	1	0.20241	1	0.012465	1	0.22624	1	0.22624	1
GALNT14	9 (6%)	146	0.17658	1	0.43411	1	0.080745	1	0.022782	1	0.04122	1	0.061141	1	0.18196	1	1	1	0.22624	1
LRRIQ3	7 (5%)	148	0.63496	1	0.63313	1	0.4703	1	0.11276	1	0.56529	1	0.8622	1	0.58519	1	1	1	0.22624	1
NAALAD2	11 (7%)	144	0.025858	1	0.13201	1	0.012724	1	0.60378	1	0.2459	1	0.092782	1	0.039746	1	1	1	0.2827	1
PCDH11X	11 (7%)	144	0.055045	1	0.67409	1	0.12922	1	NA	NA	NA	NA	0.010684	1	0.29563	1	1	1	0.30967	1
TFAP2D	5 (3%)	150	0.5784	1	1	1	0.50583	1	0.83491	1	0.67396	1	0.74315	1	0.35622	1	1	1	1	1
TNR	15 (10%)	140	0.024444	1	0.043013	1	0.0012541	1	0.66261	1	1	1	0.047315	1	0.010844	1	1	1	1	1
CNTNAP4	10 (6%)	145	0.035442	1	0.68695	1	0.02265	1	0.25475	1	1	1	0.041301	1	0.081773	1	0.2827	1	0.03248	1
DOCK2	16 (10%)	139	0.0021683	1	0.012368	1	0.0075402	1	0.3365	1	0.43829	1	0.0014209	1	0.00056554	0.554	1	1	0.43261	1
