Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.21 -9999.0 0.0 -0.559 31.0 31.0 IHH -0.043 0.163 -9999.0 0.0 -0.512 27.0 27.0 SHH Np/Cholesterol/GAS1 -0.068 0.132 -9999.0 0.0 -0.251 86.0 86.0 LRPAP1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 dorsoventral neural tube patterning 0.067 0.131 0.25 86.0 -9999.0 0.0 86.0 SMO/beta Arrestin2 -0.036 0.184 -9999.0 0.0 -0.545 19.0 19.0 SMO -0.044 0.193 -9999.0 0.0 -0.481 30.0 30.0 AKT1 -0.007 0.118 -9999.0 0.0 -0.437 9.0 9.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.017 0.113 -9999.0 0.0 -0.447 17.0 17.0 ADRBK1 0.003 0.063 -9999.0 0.0 -0.448 5.0 5.0 heart looping -0.043 0.19 -9999.0 0.0 -0.467 31.0 31.0 STIL -0.018 0.143 -9999.0 0.0 -0.461 16.0 16.0 DHH N/PTCH2 -0.031 0.123 -9999.0 0.0 -0.335 36.0 36.0 DHH N/PTCH1 -0.038 0.148 -9999.0 0.0 -0.465 13.0 13.0 PIK3CA 0.008 0.042 -9999.0 0.0 -0.476 2.0 2.0 DHH -0.024 0.124 -9999.0 0.0 -0.457 20.0 20.0 PTHLH -0.069 0.278 -9999.0 0.0 -0.848 25.0 25.0 determination of left/right symmetry -0.043 0.19 -9999.0 0.0 -0.467 31.0 31.0 PIK3R1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 skeletal system development -0.068 0.275 -9999.0 0.0 -0.837 25.0 25.0 IHH N/Hhip -0.057 0.163 -9999.0 0.0 -0.372 52.0 52.0 DHH N/Hhip -0.048 0.142 -9999.0 0.0 -0.343 48.0 48.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.043 0.19 -9999.0 0.0 -0.467 31.0 31.0 pancreas development -0.045 0.155 -9999.0 0.0 -0.47 31.0 31.0 HHAT 0.007 0.052 -9999.0 0.0 -0.476 3.0 3.0 PI3K 0.014 0.037 -9999.0 0.0 -0.334 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.123 0.213 -9999.0 0.0 -0.457 76.0 76.0 somite specification -0.043 0.19 -9999.0 0.0 -0.467 31.0 31.0 SHH Np/Cholesterol/PTCH1 -0.022 0.15 -9999.0 0.0 -0.49 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.012 0.097 -9999.0 0.0 -0.275 29.0 29.0 SHH Np/Cholesterol/Megalin -0.016 0.086 -9999.0 0.0 -0.243 32.0 32.0 SHH -0.001 0.081 -9999.0 0.0 -0.33 15.0 15.0 catabolic process -0.027 0.15 -9999.0 0.0 -0.336 43.0 43.0 SMO/Vitamin D3 -0.034 0.177 -9999.0 0.0 -0.538 20.0 20.0 SHH Np/Cholesterol/Hhip -0.025 0.114 -9999.0 0.0 -0.282 40.0 40.0 LRP2 -0.026 0.112 -9999.0 0.0 -0.441 18.0 18.0 receptor-mediated endocytosis -0.036 0.173 -9999.0 0.0 -0.507 21.0 21.0 SHH Np/Cholesterol/BOC -0.01 0.089 -9999.0 0.0 -0.253 30.0 30.0 SHH Np/Cholesterol/CDO 0.001 0.073 -9999.0 0.0 -0.257 19.0 19.0 mesenchymal cell differentiation 0.025 0.113 0.28 40.0 -9999.0 0.0 40.0 mol:Vitamin D3 -0.02 0.152 -9999.0 0.0 -0.492 16.0 16.0 IHH N/PTCH2 -0.038 0.143 -9999.0 0.0 -0.358 40.0 40.0 CDON 0.003 0.065 -9999.0 0.0 -0.462 5.0 5.0 IHH N/PTCH1 -0.026 0.152 -9999.0 0.0 -0.339 43.0 43.0 Megalin/LRPAP1 -0.011 0.083 -9999.0 0.0 -0.307 19.0 19.0 PTCH2 -0.02 0.119 -9999.0 0.0 -0.461 18.0 18.0 SHH Np/Cholesterol -0.002 0.061 -9999.0 0.0 -0.251 15.0 15.0 PTCH1 -0.027 0.15 -9999.0 0.0 -0.337 43.0 43.0 HHIP -0.045 0.155 -9999.0 0.0 -0.471 31.0 31.0