Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.047 -9999.0 0.0 -0.216 10.0 10.0 epithelial cell differentiation 0.023 0.027 -9999.0 0.0 -0.226 3.0 3.0 CYFIP2 -0.001 0.078 -9999.0 0.0 -0.476 7.0 7.0 ENAH 0.028 0.075 -9999.0 0.0 -0.337 6.0 6.0 EGFR 0.007 0.051 -9999.0 0.0 -0.465 3.0 3.0 EPHA2 0.003 0.063 -9999.0 0.0 -0.448 5.0 5.0 MYO6 0.028 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.014 0.062 -9999.0 0.0 -0.304 9.0 9.0 AQP5 -0.004 0.094 -9999.0 0.0 -0.424 8.0 8.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.026 0.029 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.008 0.088 -9999.0 0.0 -0.435 1.0 1.0 EGF -0.151 0.221 -9999.0 0.0 -0.453 92.0 92.0 NCKAP1 0.008 0.042 -9999.0 0.0 -0.476 2.0 2.0 AQP3 0.006 0.097 -9999.0 0.0 -0.449 8.0 8.0 cortical microtubule organization 0.023 0.027 -9999.0 0.0 -0.226 3.0 3.0 GO:0000145 0.024 0.028 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.027 -9999.0 0.0 -0.228 3.0 3.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.009 0.044 -9999.0 0.0 -0.372 2.0 2.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.021 0.057 -9999.0 0.0 -0.253 10.0 10.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.034 0.03 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.009 0.041 -9999.0 0.0 -0.459 2.0 2.0 ZYX 0.027 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.025 0.052 -9999.0 0.0 -0.453 1.0 1.0 CDH1 0.008 0.042 -9999.0 0.0 -0.476 2.0 2.0 EGFR/EGFR/EGF/EGF -0.07 0.096 -9999.0 0.0 -0.412 3.0 3.0 RhoA/GDP -0.003 0.026 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.03 0.031 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 IGF1R 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.046 0.156 -9999.0 0.0 -0.465 32.0 32.0 DIAPH1 -0.02 0.111 -9999.0 0.0 -0.597 9.0 9.0 Wnt receptor signaling pathway -0.023 0.027 0.226 3.0 -9999.0 0.0 3.0 RHOA 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 RhoA/GTP -0.01 0.048 -9999.0 0.0 -0.371 3.0 3.0 CTNNA1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 VCL 0.03 0.032 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.007 0.049 -9999.0 0.0 -0.453 3.0 3.0 LPP 0.031 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.008 0.042 -9999.0 0.0 -0.424 1.0 1.0 SEC6/SEC8 -0.003 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.009 0.089 -9999.0 0.0 -0.443 1.0 1.0 HGF/MET -0.01 0.046 -9999.0 0.0 -0.404 1.0 1.0 HGF -0.004 0.086 -9999.0 0.0 -0.461 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.047 -9999.0 0.0 -0.218 10.0 10.0 actin cable formation 0.042 0.073 -9999.0 0.0 -0.397 3.0 3.0 KIAA1543 0.026 0.059 -9999.0 0.0 -0.531 2.0 2.0 KIFC3 0.019 0.054 -9999.0 0.0 -0.422 1.0 1.0 NCK1 0.008 0.042 -9999.0 0.0 -0.476 2.0 2.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.028 0.026 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.014 0.037 -9999.0 0.0 -0.334 3.0 3.0 mol:GDP 0.023 0.027 -9999.0 0.0 -0.226 3.0 3.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.026 0.032 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.03 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.002 0.083 -9999.0 0.0 -0.472 8.0 8.0 ABI1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 ROCK1 0.031 0.069 -9999.0 0.0 -0.375 4.0 4.0 adherens junction assembly 0.028 0.106 -9999.0 0.0 -0.838 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.026 0.069 -9999.0 0.0 -0.424 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.016 0.029 -9999.0 0.0 -0.319 2.0 2.0 MET 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 PLEKHA7 0.026 0.039 -9999.0 0.0 -0.443 1.0 1.0 mol:GTP 0.02 0.056 -9999.0 0.0 -0.252 10.0 10.0 establishment of epithelial cell apical/basal polarity 0.043 0.038 -9999.0 0.0 -0.374 1.0 1.0 cortical actin cytoskeleton stabilization 0.016 0.047 -9999.0 0.0 -0.216 10.0 10.0 regulation of cell-cell adhesion 0.03 0.031 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.047 -9999.0 0.0 -0.218 10.0 10.0