Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.161 -9999.0 0.0 -0.549 18.0 18.0 IHH -0.011 0.134 -9999.0 0.0 -0.389 25.0 25.0 SHH Np/Cholesterol/GAS1 -0.006 0.094 -9999.0 0.0 -0.213 41.0 41.0 LRPAP1 0.027 0.026 -9999.0 0.0 -0.381 1.0 1.0 dorsoventral neural tube patterning 0.007 0.093 0.212 41.0 -9999.0 0.0 41.0 SMO/beta Arrestin2 -0.022 0.159 -9999.0 0.0 -0.374 32.0 32.0 SMO -0.036 0.159 -9999.0 0.0 -0.377 37.0 37.0 AKT1 -0.034 0.158 -9999.0 0.0 -0.422 26.0 26.0 ARRB2 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.049 -9999.0 0.0 -0.381 3.0 3.0 ADRBK1 0.029 0.028 -9999.0 0.0 -0.381 1.0 1.0 heart looping -0.036 0.157 -9999.0 0.0 -0.372 37.0 37.0 STIL -0.022 0.116 0.235 3.0 -0.296 25.0 28.0 DHH N/PTCH2 0.025 0.084 0.173 2.0 -0.271 18.0 20.0 DHH N/PTCH1 -0.006 0.121 -9999.0 0.0 -0.253 46.0 46.0 PIK3CA 0.026 0.036 -9999.0 0.0 -0.381 2.0 2.0 DHH 0.018 0.079 -9999.0 0.0 -0.381 9.0 9.0 PTHLH -0.06 0.231 -9999.0 0.0 -0.762 20.0 20.0 determination of left/right symmetry -0.036 0.157 -9999.0 0.0 -0.372 37.0 37.0 PIK3R1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.06 0.229 -9999.0 0.0 -0.754 20.0 20.0 IHH N/Hhip -0.012 0.134 -9999.0 0.0 -0.301 41.0 41.0 DHH N/Hhip 0.008 0.11 -9999.0 0.0 -0.287 30.0 30.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.036 0.157 -9999.0 0.0 -0.372 37.0 37.0 pancreas development -0.006 0.118 -9999.0 0.0 -0.38 23.0 23.0 HHAT 0.024 0.044 -9999.0 0.0 -0.381 3.0 3.0 PI3K 0.04 0.029 -9999.0 0.0 -0.271 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.011 0.146 -9999.0 0.0 -0.381 33.0 33.0 somite specification -0.036 0.157 -9999.0 0.0 -0.372 37.0 37.0 SHH Np/Cholesterol/PTCH1 -0.017 0.114 0.181 1.0 -0.294 28.0 29.0 SHH Np/Cholesterol/PTCH2 0.009 0.068 -9999.0 0.0 -0.226 18.0 18.0 SHH Np/Cholesterol/Megalin 0.016 0.052 0.201 1.0 -0.208 11.0 12.0 SHH -0.024 0.048 -9999.0 0.0 -0.271 9.0 9.0 catabolic process -0.017 0.116 -9999.0 0.0 -0.282 39.0 39.0 SMO/Vitamin D3 -0.031 0.142 0.227 1.0 -0.337 38.0 39.0 SHH Np/Cholesterol/Hhip -0.004 0.088 -9999.0 0.0 -0.238 29.0 29.0 LRP2 0.031 0.024 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.034 0.136 -9999.0 0.0 -0.369 26.0 26.0 SHH Np/Cholesterol/BOC 0.017 0.052 -9999.0 0.0 -0.207 12.0 12.0 SHH Np/Cholesterol/CDO 0.014 0.05 -9999.0 0.0 -0.205 12.0 12.0 mesenchymal cell differentiation 0.005 0.087 0.237 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.013 0.123 0.247 4.0 -0.303 26.0 30.0 IHH N/PTCH2 0.005 0.111 0.184 1.0 -0.285 28.0 29.0 CDON 0.027 0.037 -9999.0 0.0 -0.381 2.0 2.0 IHH N/PTCH1 -0.007 0.121 -9999.0 0.0 -0.284 39.0 39.0 Megalin/LRPAP1 0.042 0.028 -9999.0 0.0 -0.275 1.0 1.0 PTCH2 0.018 0.078 -9999.0 0.0 -0.381 9.0 9.0 SHH Np/Cholesterol 0.005 0.044 -9999.0 0.0 -0.2 11.0 11.0 PTCH1 -0.017 0.116 -9999.0 0.0 -0.283 39.0 39.0 HHIP -0.006 0.119 -9999.0 0.0 -0.381 23.0 23.0