Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.049 -9999.0 0.0 -0.203 12.0 12.0 epithelial cell differentiation 0.057 0.032 -9999.0 0.0 -0.198 3.0 3.0 CYFIP2 0.019 0.062 -9999.0 0.0 -0.381 6.0 6.0 ENAH -0.033 0.061 0.257 1.0 -0.327 4.0 5.0 EGFR 0.024 0.037 -9999.0 0.0 -0.381 2.0 2.0 EPHA2 0.028 0.029 -9999.0 0.0 -0.381 1.0 1.0 MYO6 -0.022 0.026 0.171 2.0 -0.194 3.0 5.0 CTNNB1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.057 -9999.0 0.0 -0.256 8.0 8.0 AQP5 -0.006 0.08 -9999.0 0.0 -0.442 7.0 7.0 CTNND1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.021 0.033 0.17 4.0 -0.192 4.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.06 0.184 4.0 -0.202 18.0 22.0 EGF -0.002 0.143 -9999.0 0.0 -0.381 30.0 30.0 NCKAP1 0.027 0.036 -9999.0 0.0 -0.381 2.0 2.0 AQP3 -0.004 0.081 -9999.0 0.0 -0.426 8.0 8.0 cortical microtubule organization 0.057 0.032 -9999.0 0.0 -0.198 3.0 3.0 GO:0000145 -0.02 0.031 0.155 4.0 -0.183 4.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.063 0.034 -9999.0 0.0 -0.2 3.0 3.0 MLLT4 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.037 0.035 -9999.0 0.0 -0.247 5.0 5.0 ARF6 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.05 -9999.0 0.0 -0.258 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.026 0.163 1.0 -0.22 1.0 2.0 PVRL2 0.028 0.027 -9999.0 0.0 -0.381 1.0 1.0 ZYX -0.023 0.026 0.171 1.0 -0.194 4.0 5.0 ARF6/GTP 0.063 0.054 -9999.0 0.0 -0.24 4.0 4.0 CDH1 0.026 0.036 -9999.0 0.0 -0.381 2.0 2.0 EGFR/EGFR/EGF/EGF 0.021 0.09 -9999.0 0.0 -0.198 33.0 33.0 RhoA/GDP 0.058 0.036 -9999.0 0.0 -0.193 4.0 4.0 actin cytoskeleton organization -0.024 0.027 0.156 1.0 -0.196 3.0 4.0 IGF-1R heterotetramer 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.027 0.026 -9999.0 0.0 -0.381 1.0 1.0 IGF1R 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.003 0.117 -9999.0 0.0 -0.381 22.0 22.0 DIAPH1 0.025 0.152 -9999.0 0.0 -0.592 13.0 13.0 Wnt receptor signaling pathway -0.057 0.032 0.198 3.0 -9999.0 0.0 3.0 RHOA 0.028 0.026 -9999.0 0.0 -0.381 1.0 1.0 RhoA/GTP -0.038 0.038 -9999.0 0.0 -0.262 6.0 6.0 CTNNA1 0.028 0.026 -9999.0 0.0 -0.381 1.0 1.0 VCL -0.024 0.027 0.157 1.0 -0.2 3.0 4.0 EFNA1 0.028 0.027 -9999.0 0.0 -0.381 1.0 1.0 LPP -0.023 0.032 0.159 4.0 -0.191 4.0 8.0 Ephrin A1/EPHA2 0.046 0.043 -9999.0 0.0 -0.233 4.0 4.0 SEC6/SEC8 -0.032 0.023 -9999.0 0.0 -0.191 4.0 4.0 MGAT3 -0.025 0.06 0.185 4.0 -0.205 18.0 22.0 HGF/MET 0.046 0.045 -9999.0 0.0 -0.196 7.0 7.0 HGF 0.025 0.046 -9999.0 0.0 -0.381 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.049 -9999.0 0.0 -0.204 12.0 12.0 actin cable formation -0.02 0.088 0.289 6.0 -0.32 7.0 13.0 KIAA1543 -0.022 0.035 0.156 4.0 -0.226 4.0 8.0 KIFC3 -0.023 0.032 0.171 1.0 -0.199 5.0 6.0 NCK1 0.026 0.036 -9999.0 0.0 -0.381 2.0 2.0 EXOC3 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.02 0.031 0.171 4.0 -0.194 3.0 7.0 NCK1/GIT1 0.038 0.035 -9999.0 0.0 -0.271 3.0 3.0 mol:GDP 0.057 0.032 -9999.0 0.0 -0.198 3.0 3.0 EXOC4 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.023 0.026 0.171 1.0 -0.194 4.0 5.0 PIP5K1C -0.021 0.033 0.171 4.0 -0.194 4.0 8.0 LIMA1 0.019 0.067 -9999.0 0.0 -0.381 7.0 7.0 ABI1 0.028 0.026 -9999.0 0.0 -0.381 1.0 1.0 ROCK1 -0.027 0.065 0.28 3.0 -0.346 3.0 6.0 adherens junction assembly -0.013 0.079 0.269 3.0 -0.476 4.0 7.0 IGF-1R heterotetramer/IGF1 0.031 0.074 -9999.0 0.0 -0.197 22.0 22.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.022 -9999.0 0.0 -0.271 1.0 1.0 MET 0.027 0.026 -9999.0 0.0 -0.381 1.0 1.0 PLEKHA7 -0.022 0.038 0.171 4.0 -0.236 4.0 8.0 mol:GTP 0.06 0.049 -9999.0 0.0 -0.257 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.023 0.058 0.31 1.0 -0.337 1.0 2.0 cortical actin cytoskeleton stabilization 0.013 0.049 -9999.0 0.0 -0.203 12.0 12.0 regulation of cell-cell adhesion -0.024 0.027 0.156 1.0 -0.196 3.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.049 -9999.0 0.0 -0.204 12.0 12.0