Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling mediated by p38-alpha and p38-beta	35.0	1546.0	44.0	-0.091	0.029	1000.0	-1000.0	-0.018	-1000.0
IL4-mediated signaling events	31.0	2824.0	91.0	-0.48	0.41	1000.0	-1000.0	-0.097	-1000.0
TCGA08_p53	30.0	212.0	7.0	-0.053	0.026	1000.0	-1000.0	-0.016	-1000.0
IL23-mediated signaling events	30.0	1853.0	60.0	-0.299	0.03	1000.0	-1000.0	-0.086	-1000.0
FOXA2 and FOXA3 transcription factor networks	22.0	1043.0	46.0	-0.234	0.03	1000.0	-1000.0	-0.097	-1000.0
Endothelins	22.0	2179.0	96.0	-0.091	0.044	1000.0	-1000.0	-0.048	-1000.0
Fc-epsilon receptor I signaling in mast cells	21.0	2072.0	97.0	-0.169	0.057	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by the Hedgehog family	20.0	1087.0	52.0	-0.06	0.042	1000.0	-1000.0	-0.028	-1000.0
HIF-1-alpha transcription factor network	20.0	1558.0	76.0	-0.118	0.03	1000.0	-1000.0	-0.058	-1000.0
Wnt signaling	19.0	135.0	7.0	-0.056	0.028	1000.0	-1000.0	-0.012	-1000.0
BCR signaling pathway	19.0	1911.0	99.0	-0.136	0.036	1000.0	-1000.0	-0.047	-1000.0
IL12-mediated signaling events	18.0	1643.0	87.0	-0.18	0.035	1000.0	-1000.0	-0.051	-1000.0
Noncanonical Wnt signaling pathway	18.0	483.0	26.0	-0.056	0.028	1000.0	-1000.0	-0.033	-1000.0
Ephrin B reverse signaling	18.0	897.0	48.0	-0.072	0.046	1000.0	-1000.0	-0.031	-1000.0
Glypican 1 network	17.0	848.0	48.0	-0.061	0.054	1000.0	-1000.0	-0.029	-1000.0
IL1-mediated signaling events	17.0	1084.0	62.0	-0.042	0.091	1000.0	-1000.0	-0.051	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1665.0	93.0	-0.062	0.043	1000.0	-1000.0	-0.041	-1000.0
Osteopontin-mediated events	16.0	616.0	38.0	-0.073	0.032	1000.0	-1000.0	-0.037	-1000.0
Thromboxane A2 receptor signaling	16.0	1688.0	105.0	-0.078	0.032	1000.0	-1000.0	-0.04	-1000.0
Reelin signaling pathway	16.0	928.0	56.0	-0.051	0.073	1000.0	-1000.0	-0.031	-1000.0
EPHB forward signaling	16.0	1363.0	85.0	-0.055	0.097	1000.0	-1000.0	-0.056	-1000.0
TCGA08_retinoblastoma	15.0	125.0	8.0	0.0	0.03	1000.0	-1000.0	-0.003	-1000.0
EGFR-dependent Endothelin signaling events	15.0	317.0	21.0	-0.045	0.048	1000.0	-1000.0	-0.037	-1000.0
Syndecan-4-mediated signaling events	15.0	1045.0	67.0	-0.036	0.041	1000.0	-1000.0	-0.031	-1000.0
Angiopoietin receptor Tie2-mediated signaling	15.0	1371.0	88.0	-0.067	0.041	1000.0	-1000.0	-0.069	-1000.0
PDGFR-beta signaling pathway	15.0	1519.0	97.0	-0.069	0.085	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	15.0	1182.0	78.0	-0.152	0.031	1000.0	-1000.0	-0.035	-1000.0
amb2 Integrin signaling	14.0	1203.0	82.0	-0.055	0.049	1000.0	-1000.0	-0.032	-1000.0
Glucocorticoid receptor regulatory network	14.0	1656.0	114.0	-0.179	0.099	1000.0	-1000.0	-0.045	-1000.0
LPA receptor mediated events	14.0	1438.0	102.0	-0.06	0.037	1000.0	-1000.0	-0.064	-1000.0
p75(NTR)-mediated signaling	13.0	1667.0	125.0	-0.07	0.068	1000.0	-1000.0	-0.06	-1000.0
BMP receptor signaling	13.0	1089.0	81.0	-0.044	0.05	1000.0	-1000.0	-0.024	-1000.0
Retinoic acid receptors-mediated signaling	13.0	768.0	58.0	-0.061	0.047	1000.0	-1000.0	-0.034	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	13.0	909.0	68.0	-0.125	0.043	1000.0	-1000.0	-0.055	-1000.0
Syndecan-1-mediated signaling events	12.0	421.0	34.0	-0.031	0.038	1000.0	-1000.0	-0.031	-1000.0
Ephrin A  reverse signaling	12.0	84.0	7.0	-0.034	0.032	1000.0	-1000.0	-0.019	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1111.0	86.0	-0.042	0.072	1000.0	-1000.0	-0.041	-1000.0
FOXM1 transcription factor network	12.0	613.0	51.0	-0.139	0.047	1000.0	-1000.0	-0.114	-1000.0
Class I PI3K signaling events	11.0	867.0	73.0	-0.053	0.036	1000.0	-1000.0	-0.032	-1000.0
IGF1 pathway	11.0	655.0	57.0	-0.041	0.057	1000.0	-1000.0	-0.044	-1000.0
VEGFR1 specific signals	11.0	664.0	56.0	-0.004	0.081	1000.0	-1000.0	-0.036	-1000.0
Caspase cascade in apoptosis	10.0	766.0	74.0	-0.046	0.05	1000.0	-1000.0	-0.034	-1000.0
Syndecan-2-mediated signaling events	10.0	756.0	69.0	-0.019	0.044	1000.0	-1000.0	-0.043	-1000.0
a4b1 and a4b7 Integrin signaling	10.0	52.0	5.0	0.009	0.028	1000.0	-1000.0	0.018	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	658.0	61.0	-0.049	0.065	1000.0	-1000.0	-0.03	-1000.0
EPO signaling pathway	10.0	596.0	55.0	-0.027	0.062	1000.0	-1000.0	-0.031	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	884.0	82.0	-0.041	0.049	1000.0	-1000.0	-0.043	-1000.0
S1P1 pathway	10.0	385.0	36.0	-0.038	0.044	1000.0	-1000.0	-0.036	-1000.0
FAS signaling pathway (CD95)	10.0	486.0	47.0	-0.077	0.048	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	10.0	875.0	84.0	-0.076	0.058	1000.0	-1000.0	-0.035	-1000.0
Canonical Wnt signaling pathway	10.0	542.0	51.0	-0.098	0.098	1000.0	-1000.0	-0.033	-1000.0
Effects of Botulinum toxin	10.0	275.0	26.0	-0.059	0.052	1000.0	-1000.0	-0.013	-1000.0
Nongenotropic Androgen signaling	10.0	568.0	52.0	-0.029	0.055	1000.0	-1000.0	-0.03	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	10.0	274.0	27.0	-0.042	0.035	1000.0	-1000.0	-0.032	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	10.0	1229.0	120.0	-0.069	0.078	1000.0	-1000.0	-0.037	-1000.0
ErbB2/ErbB3 signaling events	9.0	599.0	65.0	-0.052	0.043	1000.0	-1000.0	-0.06	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	160.0	17.0	-0.039	0.056	1000.0	-1000.0	-0.026	-1000.0
Cellular roles of Anthrax toxin	9.0	367.0	39.0	-0.034	0.028	1000.0	-1000.0	-0.018	-1000.0
Arf6 signaling events	9.0	576.0	62.0	-0.056	0.07	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PTP1B	9.0	714.0	76.0	-0.041	0.05	1000.0	-1000.0	-0.022	-1000.0
IFN-gamma pathway	9.0	614.0	68.0	-0.065	0.05	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events mediated by Akt	9.0	673.0	68.0	-0.038	0.051	1000.0	-1000.0	-0.025	-1000.0
Ceramide signaling pathway	9.0	754.0	76.0	-0.04	0.07	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	9.0	348.0	35.0	-0.019	0.064	1000.0	-1000.0	-0.01	-1000.0
Regulation of p38-alpha and p38-beta	9.0	491.0	54.0	-0.071	0.053	1000.0	-1000.0	-0.039	-1000.0
Glypican 2 network	9.0	38.0	4.0	0.014	0.028	1000.0	-1000.0	0.019	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	292.0	31.0	-0.04	0.03	1000.0	-1000.0	-0.044	-1000.0
IL6-mediated signaling events	9.0	723.0	75.0	-0.032	0.062	1000.0	-1000.0	-0.043	-1000.0
S1P4 pathway	9.0	240.0	25.0	-0.02	0.041	1000.0	-1000.0	-0.018	-1000.0
Ras signaling in the CD4+ TCR pathway	9.0	168.0	17.0	-0.018	0.035	1000.0	-1000.0	-0.019	-1000.0
Arf6 downstream pathway	8.0	352.0	43.0	-0.037	0.04	1000.0	-1000.0	-0.025	-1000.0
PLK1 signaling events	8.0	721.0	85.0	-0.018	0.061	1000.0	-1000.0	-0.029	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	8.0	316.0	37.0	-0.024	0.057	1000.0	-1000.0	-0.029	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	425.0	52.0	-0.015	0.082	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by PRL	8.0	296.0	34.0	-0.014	0.078	1000.0	-1000.0	-0.03	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.017	0.017	1000.0	-1000.0	-0.02	-1000.0
Regulation of Androgen receptor activity	8.0	574.0	70.0	-0.077	0.058	1000.0	-1000.0	-0.036	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	399.0	54.0	-0.032	0.041	1000.0	-1000.0	-0.048	-1000.0
mTOR signaling pathway	7.0	421.0	53.0	-0.081	0.035	1000.0	-1000.0	-0.036	-1000.0
S1P5 pathway	7.0	125.0	17.0	-0.008	0.033	1000.0	-1000.0	-0.006	-1000.0
Signaling mediated by p38-gamma and p38-delta	7.0	113.0	15.0	-0.025	0.028	1000.0	-1000.0	-0.027	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	7.0	334.0	45.0	-0.036	0.075	1000.0	-1000.0	-0.037	-1000.0
IL27-mediated signaling events	7.0	393.0	51.0	-0.1	0.056	1000.0	-1000.0	-0.05	-1000.0
Visual signal transduction: Rods	7.0	404.0	52.0	-0.041	0.059	1000.0	-1000.0	-0.027	-1000.0
Aurora B signaling	7.0	534.0	67.0	-0.156	0.058	1000.0	-1000.0	-0.025	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	217.0	34.0	-0.039	0.078	1000.0	-1000.0	-0.026	-1000.0
Insulin-mediated glucose transport	6.0	215.0	32.0	-0.149	0.041	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	6.0	281.0	44.0	-0.024	0.067	1000.0	-1000.0	-0.039	-1000.0
Paxillin-dependent events mediated by a4b1	6.0	224.0	36.0	-0.046	0.048	1000.0	-1000.0	-0.026	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	451.0	74.0	-0.057	0.063	1000.0	-1000.0	-0.055	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	491.0	76.0	-0.021	0.075	1000.0	-1000.0	-0.048	-1000.0
Arf6 trafficking events	6.0	449.0	71.0	-0.044	0.049	1000.0	-1000.0	-0.029	-1000.0
Regulation of Telomerase	6.0	629.0	102.0	-0.071	0.051	1000.0	-1000.0	-0.047	-1000.0
S1P3 pathway	6.0	252.0	42.0	-0.024	0.047	1000.0	-1000.0	-0.027	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	201.0	33.0	-0.01	0.067	1000.0	-1000.0	-0.025	-1000.0
LPA4-mediated signaling events	5.0	67.0	12.0	-0.029	0.004	1000.0	-1000.0	-0.023	-1000.0
Coregulation of Androgen receptor activity	5.0	452.0	76.0	-0.048	0.051	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	5.0	392.0	69.0	-0.046	0.05	1000.0	-1000.0	-0.035	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	471.0	85.0	-0.064	0.068	1000.0	-1000.0	-0.05	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	345.0	65.0	-0.027	0.048	1000.0	-1000.0	-0.031	-1000.0
Nectin adhesion pathway	5.0	367.0	63.0	-0.012	0.073	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class III	5.0	217.0	40.0	-0.048	0.052	1000.0	-1000.0	-0.032	-1000.0
ceramide signaling pathway	5.0	293.0	49.0	-0.005	0.045	1000.0	-1000.0	-0.026	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	497.0	83.0	-0.048	0.052	1000.0	-1000.0	-0.025	-1000.0
FoxO family signaling	5.0	330.0	64.0	-0.051	0.051	1000.0	-1000.0	-0.05	-1000.0
IL2 signaling events mediated by PI3K	5.0	346.0	58.0	-0.025	0.048	1000.0	-1000.0	-0.029	-1000.0
TCGA08_rtk_signaling	5.0	138.0	26.0	-0.035	0.067	1000.0	-1000.0	-0.011	-1000.0
IL2 signaling events mediated by STAT5	5.0	124.0	22.0	-0.022	0.03	1000.0	-1000.0	-0.036	-1000.0
Arf1 pathway	5.0	298.0	54.0	-0.005	0.068	1000.0	-1000.0	-0.017	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	618.0	136.0	-0.073	0.06	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class II	4.0	321.0	75.0	-0.035	0.075	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	4.0	235.0	57.0	-0.032	0.073	1000.0	-1000.0	-0.041	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	136.0	28.0	-0.025	0.044	1000.0	-1000.0	-0.025	-1000.0
HIF-2-alpha transcription factor network	4.0	198.0	43.0	-0.084	0.086	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class I	4.0	519.0	104.0	-0.056	0.069	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	621.0	125.0	-0.033	0.096	1000.0	-1000.0	-0.043	-1000.0
Insulin Pathway	4.0	353.0	74.0	-0.04	0.088	1000.0	-1000.0	-0.05	-1000.0
Canonical NF-kappaB pathway	3.0	141.0	39.0	-0.014	0.063	1000.0	-1000.0	-0.031	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.022	0.026	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Cones	3.0	150.0	38.0	-0.017	0.053	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling in keratinocytes	3.0	164.0	43.0	-0.036	0.085	1000.0	-1000.0	-0.025	-1000.0
Aurora A signaling	2.0	133.0	60.0	-0.025	0.074	1000.0	-1000.0	-0.026	-1000.0
TRAIL signaling pathway	2.0	108.0	48.0	-0.018	0.06	1000.0	-1000.0	-0.028	-1000.0
Atypical NF-kappaB pathway	2.0	68.0	31.0	-0.013	0.05	1000.0	-1000.0	-0.026	-1000.0
Rapid glucocorticoid signaling	2.0	42.0	20.0	-0.01	0.031	1000.0	-1000.0	-0.016	-1000.0
p38 MAPK signaling pathway	2.0	128.0	44.0	-0.017	0.062	1000.0	-1000.0	-0.02	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	31.0	23.0	0.005	0.039	1000.0	-1000.0	-0.015	-1000.0
Circadian rhythm pathway	1.0	29.0	22.0	-0.006	0.064	1000.0	-1000.0	-0.021	-1000.0
Aurora C signaling	1.0	13.0	7.0	0.0	0.04	1000.0	-1000.0	-0.01	-1000.0
E-cadherin signaling events	1.0	9.0	5.0	0.026	0.053	1000.0	-1000.0	0.019	-1000.0
Alternative NF-kappaB pathway	1.0	23.0	13.0	0.0	0.073	1000.0	-1000.0	0.0	-1000.0
Total	1279	78671	7203	-7.19106956204	7.25733282598	131000	-131000	-4.40324876983	-131000