Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.017 0.226 -9999.0 0.0 -0.691 19.0 19.0 IHH 0.021 0.063 -9999.0 0.0 -0.786 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.156 0.21 -9999.0 0.0 -0.612 17.0 17.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.155 0.208 0.606 17.0 -9999.0 0.0 17.0 SMO/beta Arrestin2 0.047 0.1 -9999.0 0.0 -0.703 1.0 1.0 SMO 0.04 0.106 -9999.0 0.0 -0.749 1.0 1.0 AKT1 0.051 0.053 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.04 0.105 -9999.0 0.0 -0.734 1.0 1.0 STIL -0.047 0.213 -9999.0 0.0 -0.63 12.0 12.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.041 0.1 -9999.0 0.0 -0.696 1.0 1.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.028 0.213 -9999.0 0.0 -1.154 4.0 4.0 determination of left/right symmetry 0.04 0.105 -9999.0 0.0 -0.734 1.0 1.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.028 0.209 -9999.0 0.0 -1.129 4.0 4.0 IHH N/Hhip -0.086 0.225 -9999.0 0.0 -0.512 48.0 48.0 DHH N/Hhip -0.098 0.189 -9999.0 0.0 -0.46 48.0 48.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.04 0.105 -9999.0 0.0 -0.734 1.0 1.0 pancreas development -0.122 0.266 -9999.0 0.0 -0.631 48.0 48.0 HHAT -0.053 0.201 -9999.0 0.0 -0.632 24.0 24.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.191 0.306 -9999.0 0.0 -0.64 71.0 71.0 somite specification 0.04 0.105 -9999.0 0.0 -0.734 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.005 0.149 -9999.0 0.0 -0.573 4.0 4.0 SHH Np/Cholesterol/PTCH2 -0.043 0.122 -9999.0 0.0 -0.533 3.0 3.0 SHH Np/Cholesterol/Megalin -0.045 0.124 -9999.0 0.0 -0.505 4.0 4.0 SHH -0.029 0.168 -9999.0 0.0 -0.483 26.0 26.0 catabolic process 0.036 0.113 -9999.0 0.0 -0.769 1.0 1.0 SMO/Vitamin D3 0.016 0.147 -9999.0 0.0 -0.645 2.0 2.0 SHH Np/Cholesterol/Hhip -0.118 0.206 -9999.0 0.0 -0.715 12.0 12.0 LRP2 0.014 0.049 -9999.0 0.0 -0.722 1.0 1.0 receptor-mediated endocytosis -0.05 0.111 -9999.0 0.0 -0.601 2.0 2.0 SHH Np/Cholesterol/BOC -0.043 0.122 -9999.0 0.0 -0.533 3.0 3.0 SHH Np/Cholesterol/CDO -0.043 0.122 -9999.0 0.0 -0.533 3.0 3.0 mesenchymal cell differentiation 0.117 0.204 0.707 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 0.009 0.151 -9999.0 0.0 -0.573 4.0 4.0 IHH N/PTCH2 0.029 0.039 -9999.0 0.0 -0.504 1.0 1.0 CDON 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.036 0.114 -9999.0 0.0 -0.782 1.0 1.0 Megalin/LRPAP1 -0.002 0.036 -9999.0 0.0 -0.539 1.0 1.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.044 0.125 -9999.0 0.0 -0.382 26.0 26.0 PTCH1 0.036 0.113 -9999.0 0.0 -0.773 1.0 1.0 HHIP -0.122 0.266 -9999.0 0.0 -0.632 48.0 48.0