Molecular subtypes CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL nCNV (%) nWild-Type Chi-square test_P Chi-square test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Amp Peak 1(1q21.2) 76 (24%) 246 1.2107e-07 6.4e-05 2.627e-08 1.42e-05 0.83774 1 0.35895 1 0.00050944 0.24 0.0031587 1 0.00010279 0.0502 0.27157 1 Amp Peak 2(2q11.2) 69 (21%) 253 3.4769e-06 0.00178 1.7082e-08 9.26e-06 0.93456 1 0.18772 1 0.011931 1 0.080673 1 0.044971 1 0.42876 1 Amp Peak 3(2q31.2) 67 (21%) 255 8.3764e-10 4.61e-07 9.3737e-09 5.09e-06 0.11687 1 0.35895 1 0.31834 1 0.10983 1 0.36728 1 0.081792 1 Amp Peak 4(2q32.2) 59 (18%) 263 7.9674e-07 0.000411 5.3015e-08 2.84e-05 0.049503 1 0.42742 1 0.16897 1 0.0513 1 0.043294 1 0.12919 1 Amp Peak 5(3q26.33) 242 (75%) 80 1.2931e-09 7.09e-07 3.2643e-05 0.0163 0.43466 1 0.26288 1 0.00082912 0.382 0.00028825 0.137 0.0035568 1 0.40632 1 Amp Peak 6(5p15.33) 147 (46%) 175 9.0497e-11 5.02e-08 0.025648 1 0.43657 1 0.51285 1 0.683 1 0.32024 1 0.66485 1 0.17914 1 Amp Peak 7(5p12) 122 (38%) 200 1.834e-10 1.01e-07 0.018165 1 0.82271 1 0.86006 1 0.89962 1 0.38844 1 0.81946 1 0.67627 1 Amp Peak 8(6p12.1) 64 (20%) 258 1.6452e-05 0.00829 0.0028032 1 0.95169 1 0.67624 1 0.98336 1 0.8023 1 0.74389 1 0.6664 1 Amp Peak 9(6q12) 59 (18%) 263 0.00069468 0.323 0.013845 1 0.8781 1 0.52724 1 1 1 0.82193 1 0.70534 1 0.92866 1 Amp Peak 10(7p11.2) 137 (43%) 185 1.9109e-08 1.03e-05 6.8734e-07 0.000356 0.93477 1 0.74965 1 0.50042 1 0.92323 1 0.40492 1 0.19683 1 Amp Peak 11(7q22.1) 114 (35%) 208 3.1022e-11 1.73e-08 5.4553e-08 2.91e-05 0.61697 1 1 1 0.23451 1 0.33488 1 0.06888 1 0.1006 1 Amp Peak 12(8p11.23) 102 (32%) 220 0.040905 1 0.036856 1 0.67261 1 0.41315 1 0.14966 1 0.018247 1 0.012135 1 0.007529 1 Amp Peak 13(8q11.21) 189 (59%) 133 1.0214e-06 0.000525 0.011129 1 0.90232 1 0.76362 1 0.0011291 0.515 0.00066431 0.31 0.066626 1 0.0023008 1 Amp Peak 14(8q24.21) 232 (72%) 90 5.7619e-08 3.07e-05 0.00010584 0.0515 0.2309 1 0.58032 1 0.00010228 0.05 0.00013544 0.0654 0.044151 1 0.00016946 0.0817 Amp Peak 15(9p23) 76 (24%) 246 0.0024819 1 0.78566 1 1 1 0.64697 1 0.099338 1 0.227 1 0.43822 1 0.72779 1 Amp Peak 16(9p13.3) 90 (28%) 232 0.002226 0.999 0.22203 1 0.58747 1 0.16515 1 0.0070808 1 0.037917 1 0.10668 1 0.057361 1 Amp Peak 17(11p13) 63 (20%) 259 0.01767 1 0.097141 1 0.34289 1 0.033001 1 0.63051 1 0.16315 1 0.68237 1 0.96454 1 Amp Peak 18(11p11.2) 63 (20%) 259 0.13959 1 0.53261 1 0.20303 1 0.33584 1 0.62643 1 0.14809 1 0.67082 1 0.33935 1 Amp Peak 19(11q13.3) 146 (45%) 176 1.0363e-23 5.94e-21 0.00089654 0.412 0.90415 1 0.26321 1 0.36071 1 0.50384 1 0.72287 1 0.81015 1 Amp Peak 20(12p13.33) 109 (34%) 213 5.5206e-11 3.07e-08 1.2841e-05 0.0065 0.083623 1 0.41329 1 0.0091238 1 0.0010119 0.462 0.0024677 1 0.81445 1 Amp Peak 21(12q15) 63 (20%) 259 3.7682e-08 2.03e-05 0.0084226 1 0.4252 1 0.099637 1 0.090004 1 0.045857 1 0.48631 1 0.6664 1 Amp Peak 22(13q22.1) 68 (21%) 254 4.1596e-07 0.000218 8.4301e-05 0.0416 0.0070834 1 0.33465 1 0.23284 1 0.0924 1 0.55115 1 0.40929 1 Amp Peak 23(14q11.2) 88 (27%) 234 7.3693e-06 0.00375 0.023941 1 0.63575 1 0.84475 1 0.053001 1 0.38443 1 0.006156 1 0.12594 1 Amp Peak 24(15q26.3) 71 (22%) 251 0.00010641 0.0517 0.21738 1 0.50387 1 0.93242 1 0.92275 1 0.41588 1 0.43969 1 0.26514 1 Amp Peak 25(17q12) 56 (17%) 266 4.9418e-05 0.0246 0.00011155 0.0541 0.94423 1 0.96068 1 0.016761 1 0.030759 1 0.025271 1 0.39947 1 Amp Peak 26(18p11.31) 103 (32%) 219 4.383e-07 0.000229 0.0030633 1 0.87286 1 0.73506 1 0.23777 1 0.16923 1 0.75945 1 0.72989 1 Amp Peak 27(18q11.2) 71 (22%) 251 0.013134 1 0.033009 1 0.46806 1 0.55189 1 1 1 0.68887 1 0.48977 1 0.45143 1 Amp Peak 28(20q11.22) 145 (45%) 177 0.00022537 0.108 0.022198 1 0.43588 1 0.55918 1 0.012787 1 0.085422 1 0.71463 1 0.096487 1 Amp Peak 29(Xq28) 98 (30%) 224 3.9615e-08 2.13e-05 0.003195 1 0.56144 1 0.5784 1 0.1881 1 0.46318 1 0.33848 1 0.20856 1 Del Peak 1(1p36.13) 68 (21%) 254 1.483e-10 8.22e-08 5.3785e-15 3.05e-12 0.0032151 1 0.83955 1 3.0294e-05 0.0152 0.00071584 0.332 0.013084 1 0.066758 1 Del Peak 2(1p13.2) 81 (25%) 241 2.7716e-10 1.53e-07 8.6221e-10 4.73e-07 0.0030098 1 0.047455 1 0.0054596 1 0.09271 1 0.00018064 0.0869 0.97029 1 Del Peak 3(2q21.2) 40 (12%) 282 0.28887 1 0.027827 1 0.73401 1 0.94723 1 0.015371 1 0.0056384 1 0.0034939 1 0.092962 1 Del Peak 4(2q22.1) 66 (20%) 256 0.090593 1 0.0064758 1 0.85523 1 0.33763 1 0.051329 1 0.029155 1 0.095407 1 0.00018615 0.0894 Del Peak 5(2q36.2) 96 (30%) 226 0.00012206 0.0591 5.6852e-06 0.0029 0.24751 1 0.26892 1 0.00063648 0.298 0.0012545 0.571 0.061395 1 0.010583 1 Del Peak 6(3p24.1) 239 (74%) 83 3.2462e-27 1.87e-24 3.9302e-08 2.11e-05 0.18312 1 0.24662 1 0.070659 1 0.36935 1 0.40388 1 0.098285 1 Del Peak 7(3p14.2) 242 (75%) 80 3.4131e-27 1.96e-24 5.7076e-07 0.000298 0.13669 1 0.60315 1 0.11513 1 0.16112 1 0.89503 1 0.12175 1 Del Peak 8(3p12.2) 228 (71%) 94 3.1142e-25 1.79e-22 4.0436e-09 2.2e-06 0.84279 1 0.78402 1 0.24092 1 0.46324 1 0.54087 1 0.12161 1 Del Peak 9(4p16.3) 137 (43%) 185 1.3778e-14 7.8e-12 1.4972e-05 0.00756 0.015601 1 0.71105 1 0.30679 1 0.16064 1 0.11124 1 0.59375 1 Del Peak 10(4p15.2) 138 (43%) 184 7.3603e-16 4.2e-13 5.9825e-07 0.000311 0.020712 1 0.32598 1 0.040558 1 0.012897 1 0.021407 1 0.68735 1 Del Peak 11(4q22.1) 102 (32%) 220 5.4239e-12 3.04e-09 6.4957e-07 0.000337 0.024394 1 0.76907 1 0.37116 1 0.2052 1 0.29252 1 0.70981 1 Del Peak 12(4q35.2) 131 (41%) 191 3.9958e-08 2.14e-05 2.9651e-05 0.0149 0.0040456 1 0.60179 1 0.2748 1 0.35295 1 0.29566 1 0.29223 1 Del Peak 13(5q11.2) 134 (42%) 188 1.6525e-16 9.45e-14 1.3467e-12 7.57e-10 0.095189 1 0.78558 1 0.040089 1 0.00076743 0.355 0.076048 1 0.3975 1 Del Peak 14(5q35.3) 127 (39%) 195 4.0124e-15 2.28e-12 4.2509e-14 2.4e-11 0.24287 1 0.18726 1 0.014627 1 0.00047704 0.225 0.12954 1 0.66263 1 Del Peak 15(6p25.3) 64 (20%) 258 0.0033784 1 0.00033012 0.156 0.034616 1 0.086203 1 0.0075151 1 0.37979 1 0.0053978 1 0.62529 1 Del Peak 16(7q31.1) 49 (15%) 273 0.0019675 0.887 0.026114 1 0.56319 1 0.62391 1 0.36345 1 0.60935 1 0.16719 1 0.27895 1 Del Peak 17(7q36.1) 80 (25%) 242 0.029186 1 0.33047 1 0.25105 1 0.36726 1 0.9573 1 0.67433 1 0.33917 1 0.023668 1 Del Peak 18(8p23.2) 183 (57%) 139 4.9874e-12 2.8e-09 3.8374e-05 0.0191 0.52376 1 0.23725 1 0.016617 1 0.0035288 1 0.058383 1 0.0035505 1 Del Peak 19(9p23) 151 (47%) 171 6.4533e-13 3.63e-10 5.4222e-09 2.95e-06 0.17358 1 0.84502 1 0.73968 1 0.49317 1 0.65216 1 0.22526 1 Del Peak 20(9p21.3) 189 (59%) 133 3.5223e-10 1.94e-07 2.8251e-09 1.54e-06 0.39858 1 0.64555 1 0.39019 1 0.46183 1 0.95805 1 0.6197 1 Del Peak 21(9q21.11) 61 (19%) 261 2.2402e-07 0.000118 0.00096226 0.441 0.57443 1 0.82064 1 0.88221 1 0.67272 1 0.83141 1 0.0214 1 Del Peak 22(9q34.3) 53 (16%) 269 0.00066702 0.311 0.031639 1 0.37444 1 0.11562 1 0.85073 1 0.40851 1 0.47285 1 0.27802 1 Del Peak 23(10p15.3) 108 (34%) 214 1.8402e-05 0.00926 0.029339 1 0.92905 1 0.21816 1 0.32749 1 0.30691 1 0.62101 1 0.47276 1 Del Peak 24(10p11.21) 101 (31%) 221 8.146e-06 0.00413 0.14501 1 0.6028 1 0.09241 1 0.70229 1 0.97498 1 0.9417 1 0.67026 1 Del Peak 25(10q23.31) 83 (26%) 239 0.0045412 1 0.004161 1 0.86452 1 0.69923 1 0.024871 1 0.012786 1 0.27591 1 0.76073 1 Del Peak 26(11p15.4) 102 (32%) 220 3.9138e-06 0.002 0.00052338 0.246 0.42591 1 0.59782 1 0.0022763 1 0.0070965 1 0.0033538 1 0.19607 1 Del Peak 27(11q23.1) 153 (48%) 169 1.3689e-14 7.76e-12 8.4538e-07 0.000435 0.35756 1 0.45285 1 0.00081497 0.377 0.00023024 0.11 0.20714 1 0.18164 1 Del Peak 28(12q24.33) 38 (12%) 284 0.012659 1 0.064574 1 0.024458 1 0.56983 1 0.85888 1 0.77501 1 0.49156 1 0.10981 1 Del Peak 29(13q12.11) 145 (45%) 177 8.0265e-11 4.46e-08 7.2846e-07 0.000377 0.59391 1 0.47444 1 0.053034 1 0.028941 1 0.693 1 0.31855 1 Del Peak 30(13q14.2) 137 (43%) 185 3.1019e-07 0.000163 5.8809e-07 0.000306 0.66087 1 0.25954 1 5.702e-05 0.0283 6.4644e-05 0.032 0.043051 1 0.56812 1 Del Peak 31(14q11.2) 46 (14%) 276 0.026411 1 0.0061601 1 0.51896 1 0.31666 1 0.46295 1 0.3287 1 0.089734 1 0.048668 1 Del Peak 32(14q32.32) 49 (15%) 273 0.28488 1 1.4205e-07 7.5e-05 0.31708 1 0.50706 1 0.00024216 0.116 9.7977e-05 0.048 0.11519 1 0.12581 1 Del Peak 33(15q15.1) 76 (24%) 246 0.0039211 1 0.50124 1 0.38113 1 0.13656 1 0.023265 1 0.048764 1 0.36662 1 0.25453 1 Del Peak 34(16q12.1) 54 (17%) 268 0.073147 1 1.1258e-07 5.97e-05 0.39898 1 0.076822 1 7.1021e-08 3.78e-05 3.9142e-07 0.000205 0.00036952 0.175 0.005852 1 Del Peak 35(16q23.3) 64 (20%) 258 0.073973 1 0.00083917 0.386 0.13323 1 0.03938 1 0.00060143 0.282 8.8834e-05 0.0437 0.033326 1 0.064074 1 Del Peak 36(17q25.3) 41 (13%) 281 0.047891 1 0.12256 1 0.12775 1 0.87457 1 0.036979 1 0.061224 1 0.0071986 1 0.04027 1 Del Peak 37(18q21.2) 170 (53%) 152 3.2133e-14 1.82e-11 1.6888e-09 9.24e-07 0.49717 1 0.49501 1 0.0026752 1 0.0072982 1 0.013346 1 0.031771 1 Del Peak 38(18q23) 182 (57%) 140 2.4202e-16 1.38e-13 1.3766e-11 7.7e-09 0.13635 1 0.21677 1 0.0021609 0.972 0.0033283 1 0.01512 1 0.035911 1 Del Peak 39(19p13.3) 110 (34%) 212 0.0018641 0.843 0.036842 1 0.85219 1 0.075767 1 0.087593 1 0.76122 1 0.75771 1 0.7736 1 Del Peak 40(19q13.43) 64 (20%) 258 9.256e-05 0.0454 6.9318e-05 0.0342 0.67142 1 0.13842 1 0.58361 1 0.26181 1 0.057815 1 0.77423 1 Del Peak 41(Xp21.3) 106 (33%) 216 7.7323e-06 0.00393 0.0053235 1 0.13907 1 0.037111 1 0.27514 1 0.041471 1 0.12142 1 0.83428 1 Del Peak 42(Xp11.3) 108 (34%) 214 9.6946e-08 5.15e-05 5.7969e-05 0.0288 0.13907 1 0.0049951 1 0.211 1 0.059839 1 0.17594 1 0.20982 1 Del Peak 43(Xq21.33) 55 (17%) 267 1.0691e-06 0.000548 0.0016593 0.752 0.032215 1 0.70126 1 0.0013088 0.594 0.012344 1 0.00032372 0.154 0.0052434 1