Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.185 0.193 -9999.0 0.0 -0.585 31.0 31.0 IHH -0.084 0.197 -9999.0 0.0 -0.693 42.0 42.0 SHH Np/Cholesterol/GAS1 0.003 0.1 -9999.0 0.0 -0.375 28.0 28.0 LRPAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.099 0.372 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.089 0.151 -9999.0 0.0 -0.518 25.0 25.0 SMO -0.1 0.15 -9999.0 0.0 -0.536 25.0 25.0 AKT1 -0.034 0.108 -9999.0 0.0 -0.551 10.0 10.0 ARRB2 0.027 0.034 -9999.0 0.0 -0.706 1.0 1.0 BOC 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.099 0.148 -9999.0 0.0 -0.528 25.0 25.0 STIL -0.074 0.133 -9999.0 0.0 -0.524 6.0 6.0 DHH N/PTCH2 0.007 0.125 -9999.0 0.0 -0.443 33.0 33.0 DHH N/PTCH1 -0.108 0.153 -9999.0 0.0 -0.491 34.0 34.0 PIK3CA 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.014 0.096 -9999.0 0.0 -0.639 10.0 10.0 PTHLH -0.287 0.272 -9999.0 0.0 -0.795 38.0 38.0 determination of left/right symmetry -0.099 0.148 -9999.0 0.0 -0.528 25.0 25.0 PIK3R1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.285 0.27 -9999.0 0.0 -0.786 38.0 38.0 IHH N/Hhip -0.163 0.254 -9999.0 0.0 -0.536 142.0 142.0 DHH N/Hhip -0.092 0.227 -9999.0 0.0 -0.478 119.0 119.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.099 0.148 -9999.0 0.0 -0.528 25.0 25.0 pancreas development -0.134 0.281 -9999.0 0.0 -0.625 116.0 116.0 HHAT 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.009 0.15 -9999.0 0.0 -0.584 29.0 29.0 somite specification -0.099 0.148 -9999.0 0.0 -0.528 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.085 0.13 -9999.0 0.0 -0.444 26.0 26.0 SHH Np/Cholesterol/PTCH2 0.006 0.092 -9999.0 0.0 -0.344 29.0 29.0 SHH Np/Cholesterol/Megalin -0.004 0.117 -9999.0 0.0 -0.415 31.0 31.0 SHH 0.011 0.068 -9999.0 0.0 -0.472 9.0 9.0 catabolic process -0.126 0.157 -9999.0 0.0 -0.522 31.0 31.0 SMO/Vitamin D3 -0.087 0.14 -9999.0 0.0 -0.488 26.0 26.0 SHH Np/Cholesterol/Hhip -0.068 0.175 -9999.0 0.0 -0.383 104.0 104.0 LRP2 -0.022 0.173 -9999.0 0.0 -0.598 38.0 38.0 receptor-mediated endocytosis -0.1 0.164 -9999.0 0.0 -0.651 17.0 17.0 SHH Np/Cholesterol/BOC 0.022 0.056 -9999.0 0.0 -0.366 9.0 9.0 SHH Np/Cholesterol/CDO -0.017 0.122 -9999.0 0.0 -0.34 57.0 57.0 mesenchymal cell differentiation 0.068 0.173 0.38 104.0 -9999.0 0.0 104.0 mol:Vitamin D3 -0.079 0.139 -9999.0 0.0 -0.448 26.0 26.0 IHH N/PTCH2 -0.061 0.167 -9999.0 0.0 -0.467 64.0 64.0 CDON -0.042 0.198 -9999.0 0.0 -0.588 55.0 55.0 IHH N/PTCH1 -0.126 0.16 -9999.0 0.0 -0.528 31.0 31.0 Megalin/LRPAP1 0.004 0.131 -9999.0 0.0 -0.474 31.0 31.0 PTCH2 -0.003 0.135 -9999.0 0.0 -0.588 24.0 24.0 SHH Np/Cholesterol 0.011 0.054 -9999.0 0.0 -0.37 9.0 9.0 PTCH1 -0.126 0.158 -9999.0 0.0 -0.524 31.0 31.0 HHIP -0.134 0.282 -9999.0 0.0 -0.626 116.0 116.0