Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.399 0.268 0.555 54.0 -9999.0 0.0 54.0 KIRREL -0.085 0.122 -9999.0 0.0 -0.755 2.0 2.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.399 0.269 -9999.0 0.0 -0.556 54.0 54.0 PLCG1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.451 0.319 -9999.0 0.0 -0.602 58.0 58.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.378 0.276 -9999.0 0.0 -0.53 52.0 52.0 FYN -0.443 0.277 -9999.0 0.0 -0.569 58.0 58.0 mol:Ca2+ -0.444 0.313 -9999.0 0.0 -0.602 56.0 56.0 mol:DAG -0.447 0.316 -9999.0 0.0 -0.606 56.0 56.0 NPHS2 -0.401 0.335 -9999.0 0.0 -0.717 40.0 40.0 mol:IP3 -0.447 0.316 -9999.0 0.0 -0.606 56.0 56.0 regulation of endocytosis -0.403 0.282 -9999.0 0.0 -0.545 56.0 56.0 Nephrin/NEPH1/podocin/Cholesterol -0.455 0.311 -9999.0 0.0 -0.593 59.0 59.0 establishment of cell polarity -0.399 0.268 -9999.0 0.0 -0.555 54.0 54.0 Nephrin/NEPH1/podocin/NCK1-2 -0.426 0.307 -9999.0 0.0 -0.575 57.0 57.0 Nephrin/NEPH1/beta Arrestin2 -0.41 0.288 -9999.0 0.0 -0.554 56.0 56.0 NPHS1 -0.504 0.304 -9999.0 0.0 -0.694 54.0 54.0 Nephrin/NEPH1/podocin -0.435 0.298 -9999.0 0.0 -0.573 58.0 58.0 TJP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.45 0.318 -9999.0 0.0 -0.61 56.0 56.0 CD2AP 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.445 0.317 -9999.0 0.0 -0.61 55.0 55.0 GRB2 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.494 0.294 -9999.0 0.0 -0.608 61.0 61.0 cytoskeleton organization -0.468 0.332 -9999.0 0.0 -0.632 56.0 56.0 Nephrin/NEPH1 -0.293 0.206 -9999.0 0.0 -0.411 54.0 54.0 Nephrin/NEPH1/ZO-1 -0.33 0.234 -9999.0 0.0 -0.486 50.0 50.0