Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.143 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.085 0.274 -9999.0 0.0 -0.687 13.0 13.0 SHH Np/Cholesterol/GAS1 -0.002 0.086 -9999.0 0.0 -0.356 4.0 4.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.002 0.086 0.353 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 -0.035 0.187 -9999.0 0.0 -0.469 8.0 8.0 SMO -0.054 0.176 -9999.0 0.0 -0.468 10.0 10.0 AKT1 -0.038 0.163 -9999.0 0.0 -0.662 3.0 3.0 ARRB2 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.059 0.176 -9999.0 0.0 -0.46 10.0 10.0 STIL -0.036 0.136 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.023 0.088 -9999.0 0.0 -0.505 2.0 2.0 DHH N/PTCH1 -0.042 0.161 -9999.0 0.0 -0.363 15.0 15.0 PIK3CA 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.002 0.111 -9999.0 0.0 -0.662 2.0 2.0 PTHLH -0.055 0.172 -9999.0 0.0 -0.446 10.0 10.0 determination of left/right symmetry -0.059 0.176 -9999.0 0.0 -0.46 10.0 10.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.055 0.171 -9999.0 0.0 -0.443 10.0 10.0 IHH N/Hhip -0.079 0.221 -9999.0 0.0 -0.472 18.0 18.0 DHH N/Hhip -0.013 0.157 -9999.0 0.0 -0.505 7.0 7.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.059 0.176 -9999.0 0.0 -0.46 10.0 10.0 pancreas development -0.02 0.17 -9999.0 0.0 -0.661 5.0 5.0 HHAT 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.001 0.134 -9999.0 0.0 -0.662 3.0 3.0 somite specification -0.059 0.176 -9999.0 0.0 -0.46 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.039 0.126 -9999.0 0.0 -0.326 10.0 10.0 SHH Np/Cholesterol/PTCH2 0.013 0.05 -9999.0 0.0 -0.406 1.0 1.0 SHH Np/Cholesterol/Megalin -0.043 0.15 -9999.0 0.0 -0.406 11.0 11.0 SHH -0.021 0.057 -9999.0 0.0 -0.506 1.0 1.0 catabolic process -0.046 0.159 -9999.0 0.0 -0.394 13.0 13.0 SMO/Vitamin D3 -0.046 0.154 -9999.0 0.0 -0.42 8.0 8.0 SHH Np/Cholesterol/Hhip -0.014 0.108 -9999.0 0.0 -0.375 6.0 6.0 LRP2 -0.063 0.233 -9999.0 0.0 -0.662 10.0 10.0 receptor-mediated endocytosis -0.086 0.209 -9999.0 0.0 -0.662 6.0 6.0 SHH Np/Cholesterol/BOC 0.013 0.05 -9999.0 0.0 -0.406 1.0 1.0 SHH Np/Cholesterol/CDO 0.014 0.051 -9999.0 0.0 -0.406 1.0 1.0 mesenchymal cell differentiation 0.014 0.107 0.373 6.0 -9999.0 0.0 6.0 mol:Vitamin D3 -0.01 0.155 0.36 1.0 -0.332 9.0 10.0 IHH N/PTCH2 -0.04 0.185 -9999.0 0.0 -0.445 13.0 13.0 CDON 0.031 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.038 0.164 -9999.0 0.0 -0.398 13.0 13.0 Megalin/LRPAP1 -0.031 0.184 -9999.0 0.0 -0.503 10.0 10.0 PTCH2 0.027 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.015 0.045 -9999.0 0.0 -0.4 1.0 1.0 PTCH1 -0.046 0.159 -9999.0 0.0 -0.395 13.0 13.0 HHIP -0.02 0.171 -9999.0 0.0 -0.662 5.0 5.0