Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.006 0.079 -9999.0 0.0 -0.294 5.0 5.0 epithelial cell differentiation 0.021 0.111 -9999.0 0.0 -0.386 5.0 5.0 CYFIP2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.019 0.143 0.554 3.0 -9999.0 0.0 3.0 EGFR 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.021 0.127 0.328 3.0 -0.377 5.0 8.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.02 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.103 0.21 -9999.0 0.0 -0.59 10.0 10.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.018 0.127 0.326 3.0 -0.371 5.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.043 0.147 0.338 2.0 -0.418 7.0 9.0 EGF -0.524 0.267 -9999.0 0.0 -0.647 62.0 62.0 NCKAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.152 0.24 -9999.0 0.0 -0.568 16.0 16.0 cortical microtubule organization 0.021 0.111 -9999.0 0.0 -0.386 5.0 5.0 GO:0000145 -0.018 0.12 0.313 3.0 -0.354 5.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.113 -9999.0 0.0 -0.39 5.0 5.0 MLLT4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.054 0.075 -9999.0 0.0 -0.351 4.0 4.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.031 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.026 0.095 -9999.0 0.0 -0.347 5.0 5.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.036 0.1 -9999.0 0.0 -0.377 5.0 5.0 ARF6/GTP 0.061 0.035 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.02 0.171 -9999.0 0.0 -0.662 5.0 5.0 EGFR/EGFR/EGF/EGF -0.264 0.185 -9999.0 0.0 -0.396 45.0 45.0 RhoA/GDP 0.024 0.108 -9999.0 0.0 -0.373 5.0 5.0 actin cytoskeleton organization -0.023 0.121 0.307 3.0 -0.367 5.0 8.0 IGF-1R heterotetramer 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.018 0.079 -9999.0 0.0 -0.662 1.0 1.0 DIAPH1 0.023 0.122 -9999.0 0.0 -0.572 1.0 1.0 Wnt receptor signaling pathway -0.021 0.111 0.386 5.0 -9999.0 0.0 5.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.055 0.075 -9999.0 0.0 -0.354 4.0 4.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.023 0.123 0.309 3.0 -0.376 5.0 8.0 EFNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.03 0.111 0.329 1.0 -0.365 5.0 6.0 Ephrin A1/EPHA2 0.014 0.105 -9999.0 0.0 -0.371 5.0 5.0 SEC6/SEC8 -0.052 0.084 -9999.0 0.0 -0.362 5.0 5.0 MGAT3 -0.044 0.149 0.341 2.0 -0.426 7.0 9.0 HGF/MET 0.003 0.116 -9999.0 0.0 -0.372 6.0 6.0 HGF 0.005 0.11 -9999.0 0.0 -0.662 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.006 0.079 -9999.0 0.0 -0.296 5.0 5.0 actin cable formation 0.021 0.179 0.546 6.0 -9999.0 0.0 6.0 KIAA1543 -0.018 0.122 0.315 3.0 -0.36 5.0 8.0 KIFC3 -0.044 0.094 -9999.0 0.0 -0.377 5.0 5.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.018 0.128 0.328 3.0 -0.377 5.0 8.0 NCK1/GIT1 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.021 0.111 -9999.0 0.0 -0.386 5.0 5.0 EXOC4 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.043 0.094 -9999.0 0.0 -0.377 5.0 5.0 PIP5K1C -0.019 0.128 0.328 3.0 -0.377 5.0 8.0 LIMA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.172 0.48 6.0 -9999.0 0.0 6.0 adherens junction assembly 0.0 0.144 0.399 4.0 -0.33 3.0 7.0 IGF-1R heterotetramer/IGF1 0.01 0.115 -9999.0 0.0 -0.372 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.019 0.128 0.328 3.0 -0.377 5.0 8.0 mol:GTP 0.055 0.03 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.029 0.116 0.301 2.0 -0.354 5.0 7.0 cortical actin cytoskeleton stabilization -0.006 0.079 -9999.0 0.0 -0.294 5.0 5.0 regulation of cell-cell adhesion -0.023 0.121 0.307 3.0 -0.367 5.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.006 0.079 -9999.0 0.0 -0.296 5.0 5.0