Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	35.0	1212.0	34.0	-0.504	0.028	1000.0	-1000.0	-0.041	-1000.0
FOXA2 and FOXA3 transcription factor networks	27.0	1275.0	46.0	-1.185	0.03	1000.0	-1000.0	-0.083	-1000.0
EGFR-dependent Endothelin signaling events	21.0	457.0	21.0	-0.524	0.036	1000.0	-1000.0	-0.049	-1000.0
Angiopoietin receptor Tie2-mediated signaling	17.0	1527.0	88.0	-0.695	0.063	1000.0	-1000.0	-0.063	-1000.0
Glypican 1 network	11.0	530.0	48.0	-0.368	0.05	1000.0	-1000.0	-0.044	-1000.0
Thromboxane A2 receptor signaling	10.0	1050.0	105.0	-0.524	0.079	1000.0	-1000.0	-0.044	-1000.0
PDGFR-alpha signaling pathway	10.0	467.0	44.0	-0.246	0.035	1000.0	-1000.0	-0.042	-1000.0
BMP receptor signaling	8.0	671.0	81.0	-0.366	0.053	1000.0	-1000.0	-0.052	-1000.0
Arf6 signaling events	6.0	380.0	62.0	-0.524	0.057	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by PTP1B	6.0	472.0	76.0	-0.527	0.088	1000.0	-1000.0	-0.042	-1000.0
amb2 Integrin signaling	6.0	548.0	82.0	-0.506	0.062	1000.0	-1000.0	-0.059	-1000.0
Endothelins	6.0	598.0	96.0	-0.541	0.05	1000.0	-1000.0	-0.053	-1000.0
Signaling mediated by p38-alpha and p38-beta	6.0	301.0	44.0	-0.109	0.027	1000.0	-1000.0	-0.045	-1000.0
Integrins in angiogenesis	6.0	504.0	84.0	-0.436	0.059	1000.0	-1000.0	-0.079	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	747.0	120.0	-0.196	0.129	1000.0	-1000.0	-0.069	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	471.0	78.0	-0.222	0.049	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by the Hedgehog family	5.0	293.0	52.0	-0.086	0.039	1000.0	-1000.0	-0.047	-1000.0
IL4-mediated signaling events	5.0	516.0	91.0	-0.831	0.357	1000.0	-1000.0	-0.122	-1000.0
FoxO family signaling	5.0	332.0	64.0	-1.012	0.07	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	693.0	125.0	-0.101	0.056	1000.0	-1000.0	-0.072	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	375.0	74.0	-0.524	0.061	1000.0	-1000.0	-0.079	-1000.0
FOXM1 transcription factor network	5.0	259.0	51.0	0.024	0.226	1000.0	-1000.0	-0.099	-1000.0
Glucocorticoid receptor regulatory network	4.0	496.0	114.0	-0.445	0.141	1000.0	-1000.0	-0.056	-1000.0
Ceramide signaling pathway	4.0	379.0	76.0	-0.524	0.187	1000.0	-1000.0	-0.051	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	438.0	93.0	-0.187	0.109	1000.0	-1000.0	-0.062	-1000.0
Noncanonical Wnt signaling pathway	3.0	96.0	26.0	-0.225	0.041	1000.0	-1000.0	-0.057	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	256.0	85.0	-0.133	0.128	1000.0	-1000.0	-0.042	-1000.0
p75(NTR)-mediated signaling	3.0	391.0	125.0	-0.471	0.072	1000.0	-1000.0	-0.093	-1000.0
ceramide signaling pathway	3.0	147.0	49.0	-0.021	0.039	1000.0	-1000.0	-0.05	-1000.0
S1P1 pathway	3.0	112.0	36.0	-0.09	0.027	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	51.0	15.0	-0.017	0.028	1000.0	-1000.0	-0.039	-1000.0
Syndecan-3-mediated signaling events	3.0	109.0	35.0	-0.086	0.072	1000.0	-1000.0	-0.046	-1000.0
Nongenotropic Androgen signaling	3.0	172.0	52.0	-0.136	0.061	1000.0	-1000.0	-0.046	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	264.0	68.0	-0.396	0.079	1000.0	-1000.0	-0.082	-1000.0
IL23-mediated signaling events	3.0	189.0	60.0	-0.021	0.053	1000.0	-1000.0	-0.099	-1000.0
Plasma membrane estrogen receptor signaling	3.0	292.0	86.0	-0.084	0.049	1000.0	-1000.0	-0.06	-1000.0
E-cadherin signaling in keratinocytes	3.0	129.0	43.0	-0.209	0.03	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling events	3.0	15.0	5.0	-0.02	0.027	1000.0	-1000.0	0.006	-1000.0
LPA4-mediated signaling events	2.0	29.0	12.0	-0.095	0.007	1000.0	-1000.0	-0.029	-1000.0
ErbB2/ErbB3 signaling events	2.0	150.0	65.0	-0.037	0.068	1000.0	-1000.0	-0.076	-1000.0
Caspase cascade in apoptosis	2.0	211.0	74.0	-0.401	0.07	1000.0	-1000.0	-0.054	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	312.0	136.0	-0.391	0.088	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	2.0	206.0	76.0	-0.693	0.088	1000.0	-1000.0	-0.031	-1000.0
ErbB4 signaling events	2.0	155.0	69.0	-0.221	0.095	1000.0	-1000.0	-0.047	-1000.0
Osteopontin-mediated events	2.0	78.0	38.0	-0.087	0.05	1000.0	-1000.0	-0.056	-1000.0
Ephrin A  reverse signaling	2.0	15.0	7.0	-0.026	0.018	1000.0	-1000.0	-0.028	-1000.0
HIF-1-alpha transcription factor network	2.0	167.0	76.0	-0.087	0.157	1000.0	-1000.0	-0.085	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	147.0	61.0	-0.097	0.072	1000.0	-1000.0	-0.042	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	228.0	97.0	-0.087	0.095	1000.0	-1000.0	-0.068	-1000.0
IFN-gamma pathway	2.0	169.0	68.0	-0.414	0.067	1000.0	-1000.0	-0.073	-1000.0
Reelin signaling pathway	2.0	116.0	56.0	-0.067	0.065	1000.0	-1000.0	-0.057	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	189.0	82.0	-0.056	0.033	1000.0	-1000.0	-0.07	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	130.0	52.0	-0.227	0.077	1000.0	-1000.0	-0.054	-1000.0
Regulation of p38-alpha and p38-beta	2.0	109.0	54.0	-0.063	0.058	1000.0	-1000.0	-0.051	-1000.0
Effects of Botulinum toxin	2.0	66.0	26.0	-0.166	0.083	1000.0	-1000.0	-0.02	-1000.0
IL27-mediated signaling events	2.0	112.0	51.0	-0.835	0.294	1000.0	-1000.0	-0.054	-1000.0
TCGA08_rtk_signaling	2.0	57.0	26.0	-0.123	0.071	1000.0	-1000.0	-0.011	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	201.0	76.0	-0.051	0.048	1000.0	-1000.0	-0.071	-1000.0
Regulation of Telomerase	2.0	225.0	102.0	-0.522	0.064	1000.0	-1000.0	-0.057	-1000.0
BCR signaling pathway	2.0	205.0	99.0	-0.062	0.07	1000.0	-1000.0	-0.075	-1000.0
PDGFR-beta signaling pathway	2.0	211.0	97.0	-0.034	0.064	1000.0	-1000.0	-0.069	-1000.0
Regulation of Androgen receptor activity	2.0	140.0	70.0	-0.78	0.045	1000.0	-1000.0	-0.067	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	38.0	17.0	-0.026	0.039	1000.0	-1000.0	-0.03	-1000.0
IL12-mediated signaling events	1.0	136.0	87.0	-0.189	0.068	1000.0	-1000.0	-0.078	-1000.0
Syndecan-1-mediated signaling events	1.0	46.0	34.0	-0.026	0.042	1000.0	-1000.0	-0.05	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	31.0	28.0	-0.078	0.051	1000.0	-1000.0	-0.035	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	74.0	54.0	-0.02	0.083	1000.0	-1000.0	-0.066	-1000.0
Syndecan-2-mediated signaling events	1.0	128.0	69.0	-0.506	0.062	1000.0	-1000.0	-0.046	-1000.0
Cellular roles of Anthrax toxin	1.0	66.0	39.0	-0.11	0.035	1000.0	-1000.0	-0.027	-1000.0
Arf6 downstream pathway	1.0	53.0	43.0	-0.042	0.043	1000.0	-1000.0	-0.03	-1000.0
EPO signaling pathway	1.0	63.0	55.0	-0.011	0.054	1000.0	-1000.0	-0.057	-1000.0
PLK1 signaling events	1.0	166.0	85.0	-0.009	0.066	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	1.0	81.0	43.0	-0.132	0.075	1000.0	-1000.0	-0.053	-1000.0
Ephrin B reverse signaling	1.0	80.0	48.0	-0.052	0.054	1000.0	-1000.0	-0.037	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	89.0	83.0	-0.224	0.058	1000.0	-1000.0	-0.046	-1000.0
IL2 signaling events mediated by PI3K	1.0	99.0	58.0	-0.032	0.062	1000.0	-1000.0	-0.037	-1000.0
Canonical Wnt signaling pathway	1.0	73.0	51.0	-0.094	0.08	1000.0	-1000.0	-0.055	-1000.0
EPHB forward signaling	1.0	148.0	85.0	-0.061	0.063	1000.0	-1000.0	-0.082	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	42.0	31.0	-0.09	0.052	1000.0	-1000.0	-0.052	-1000.0
Wnt signaling	1.0	7.0	7.0	-0.006	0.041	1000.0	-1000.0	-0.03	-1000.0
LPA receptor mediated events	1.0	161.0	102.0	-0.087	0.042	1000.0	-1000.0	-0.064	-1000.0
IL6-mediated signaling events	1.0	140.0	75.0	-0.271	0.04	1000.0	-1000.0	-0.049	-1000.0
Arf6 trafficking events	1.0	135.0	71.0	-0.251	0.043	1000.0	-1000.0	-0.034	-1000.0
Syndecan-4-mediated signaling events	1.0	130.0	67.0	-0.465	0.157	1000.0	-1000.0	-0.049	-1000.0
S1P3 pathway	1.0	74.0	42.0	-0.078	0.041	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Rods	1.0	96.0	52.0	-0.129	0.058	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by PRL	1.0	44.0	34.0	-0.044	0.04	1000.0	-1000.0	-0.05	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.019	0.019	1000.0	-1000.0	-0.01	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.021	0.045	1000.0	-1000.0	-0.035	-1000.0
Canonical NF-kappaB pathway	0.0	5.0	39.0	-0.017	0.055	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class II	0.0	38.0	75.0	-0.064	0.063	1000.0	-1000.0	-0.044	-1000.0
BARD1 signaling events	0.0	35.0	57.0	-0.052	0.068	1000.0	-1000.0	-0.058	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	-0.01	-1000.0	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Cones	0.0	19.0	38.0	-0.021	0.05	1000.0	-1000.0	-0.032	-1000.0
Circadian rhythm pathway	0.0	0.0	22.0	-0.013	0.059	1000.0	-1000.0	-0.039	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	8.0	17.0	0.015	0.064	1000.0	-1000.0	-0.037	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.027	0.04	1000.0	-1000.0	0.006	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	51.0	65.0	-0.006	0.066	1000.0	-1000.0	-0.051	-1000.0
Aurora A signaling	0.0	4.0	60.0	-0.009	0.065	1000.0	-1000.0	-0.045	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.072	1000.0	-1000.0	-0.018	-1000.0
Insulin-mediated glucose transport	0.0	25.0	32.0	-0.018	0.058	1000.0	-1000.0	-0.037	-1000.0
mTOR signaling pathway	0.0	52.0	53.0	-0.025	0.047	1000.0	-1000.0	-0.046	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	48.0	68.0	-0.023	0.058	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	0.0	46.0	63.0	-0.02	0.074	1000.0	-1000.0	-0.05	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	3.0	37.0	-0.015	0.072	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by HDAC Class III	0.0	6.0	40.0	-0.047	0.049	1000.0	-1000.0	-0.038	-1000.0
TRAIL signaling pathway	0.0	5.0	48.0	-0.017	0.065	1000.0	-1000.0	-0.047	-1000.0
IL1-mediated signaling events	0.0	60.0	62.0	-0.073	0.081	1000.0	-1000.0	-0.084	-1000.0
S1P5 pathway	0.0	8.0	17.0	-0.01	0.027	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class I	0.0	43.0	104.0	-0.064	0.067	1000.0	-1000.0	-0.046	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.035	0.027	1000.0	-1000.0	-0.02	-1000.0
FAS signaling pathway (CD95)	0.0	35.0	47.0	-0.088	0.04	1000.0	-1000.0	-0.045	-1000.0
Retinoic acid receptors-mediated signaling	0.0	42.0	58.0	-0.009	0.062	1000.0	-1000.0	-0.054	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.05	0.057	1000.0	-1000.0	-0.042	-1000.0
Atypical NF-kappaB pathway	0.0	5.0	31.0	-0.018	0.039	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	35.0	45.0	-0.011	0.07	1000.0	-1000.0	-0.064	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.042	0.054	1000.0	-1000.0	0.005	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.023	0.062	1000.0	-1000.0	-0.052	-1000.0
IL2 signaling events mediated by STAT5	0.0	7.0	22.0	-0.008	0.063	1000.0	-1000.0	-0.045	-1000.0
Class I PI3K signaling events	0.0	65.0	73.0	-0.033	0.043	1000.0	-1000.0	-0.051	-1000.0
TCGA08_retinoblastoma	0.0	5.0	8.0	-0.021	0.09	1000.0	-1000.0	-0.004	-1000.0
IGF1 pathway	0.0	34.0	57.0	-0.037	0.062	1000.0	-1000.0	-0.07	-1000.0
Insulin Pathway	0.0	49.0	74.0	-0.059	0.065	1000.0	-1000.0	-0.074	-1000.0
VEGFR1 specific signals	0.0	10.0	56.0	-0.022	0.065	1000.0	-1000.0	-0.056	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	21.0	33.0	-0.015	0.088	1000.0	-1000.0	-0.039	-1000.0
Rapid glucocorticoid signaling	0.0	1.0	20.0	-0.01	0.033	1000.0	-1000.0	-0.018	-1000.0
S1P4 pathway	0.0	9.0	25.0	-0.004	0.04	1000.0	-1000.0	-0.033	-1000.0
p38 MAPK signaling pathway	0.0	14.0	44.0	-0.0	0.043	1000.0	-1000.0	-0.035	-1000.0
Arf1 pathway	0.0	11.0	54.0	-0.01	0.055	1000.0	-1000.0	-0.027	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.067	1000.0	-1000.0	-0.0	-1000.0
Aurora B signaling	0.0	45.0	67.0	-0.142	0.124	1000.0	-1000.0	-0.044	-1000.0
Total	343	23896	7203	-22.7781013178	-991.342609637	131000	-131000	-6.35698279568	-131000