Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.053 0.091 -9999.0 0.0 -0.203 4.0 4.0 epithelial cell differentiation 0.007 0.106 -9999.0 0.0 -0.204 3.0 3.0 CYFIP2 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.051 0.204 0.694 1.0 -9999.0 0.0 1.0 EGFR -0.036 0.127 -9999.0 0.0 -0.278 3.0 3.0 EPHA2 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.048 0.128 0.331 1.0 -9999.0 0.0 1.0 CTNNB1 -0.044 0.152 -9999.0 0.0 -0.359 3.0 3.0 ABI1/Sra1/Nap1 0.058 0.024 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.045 0.071 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.048 0.127 0.329 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.047 0.126 0.329 1.0 -9999.0 0.0 1.0 EGF -0.022 0.104 -9999.0 0.0 -0.176 4.0 4.0 NCKAP1 0.022 0.035 -9999.0 0.0 -0.115 1.0 1.0 AQP3 -0.08 0.153 -9999.0 0.0 -0.465 2.0 2.0 cortical microtubule organization 0.007 0.106 -9999.0 0.0 -0.204 3.0 3.0 GO:0000145 -0.047 0.119 0.31 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.011 0.11 -9999.0 0.0 -0.206 3.0 3.0 MLLT4 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.098 0.067 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.055 0.047 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.051 0.088 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.055 0.09 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.071 0.052 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.015 0.101 -9999.0 0.0 -0.196 3.0 3.0 EGFR/EGFR/EGF/EGF -0.106 0.113 -9999.0 0.0 -0.254 5.0 5.0 RhoA/GDP -0.014 0.119 -9999.0 0.0 -0.213 4.0 4.0 actin cytoskeleton organization -0.054 0.122 0.305 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.02 0.036 -9999.0 0.0 -9999.0 0.0 0.0 DIAPH1 0.014 0.145 -9999.0 0.0 -0.543 1.0 1.0 Wnt receptor signaling pathway -0.007 0.106 0.204 3.0 -9999.0 0.0 3.0 RHOA 0.005 0.094 -9999.0 0.0 -0.359 1.0 1.0 RhoA/GTP -0.107 0.078 -9999.0 0.0 -0.251 1.0 1.0 CTNNA1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.056 0.123 0.307 1.0 -9999.0 0.0 1.0 EFNA1 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.075 0.079 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.082 0.067 -9999.0 0.0 -0.208 3.0 3.0 SEC6/SEC8 -0.078 0.078 -9999.0 0.0 -0.218 2.0 2.0 MGAT3 -0.048 0.128 0.331 1.0 -9999.0 0.0 1.0 HGF/MET -0.059 0.066 -9999.0 0.0 -0.21 2.0 2.0 HGF 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.053 0.092 -9999.0 0.0 -0.205 4.0 4.0 actin cable formation -0.005 0.226 0.486 2.0 -0.273 1.0 3.0 KIAA1543 -0.042 0.12 0.312 1.0 -9999.0 0.0 1.0 KIFC3 -0.088 0.072 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.047 0.127 0.331 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.007 0.106 -9999.0 0.0 -0.204 3.0 3.0 EXOC4 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.077 0.067 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.048 0.128 0.331 1.0 -9999.0 0.0 1.0 LIMA1 0.005 0.094 -9999.0 0.0 -0.359 1.0 1.0 ABI1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.047 0.221 0.734 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.042 0.167 0.334 2.0 -0.299 1.0 3.0 IGF-1R heterotetramer/IGF1 -0.087 0.068 -9999.0 0.0 -0.218 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.043 0.128 0.331 1.0 -9999.0 0.0 1.0 mol:GTP 0.053 0.046 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.05 0.113 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.053 0.091 -9999.0 0.0 -0.203 4.0 4.0 regulation of cell-cell adhesion -0.054 0.122 0.305 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.053 0.092 -9999.0 0.0 -0.205 4.0 4.0