Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.026 0.132 -9999.0 0.0 -0.393 11.0 11.0 IHH -0.01 0.065 -9999.0 0.0 -0.289 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.018 0.08 -9999.0 0.0 -0.202 20.0 20.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.018 0.079 0.201 20.0 -9999.0 0.0 20.0 SMO/beta Arrestin2 -0.052 0.145 -9999.0 0.0 -0.447 10.0 10.0 SMO -0.063 0.151 -9999.0 0.0 -0.475 10.0 10.0 AKT1 -0.008 0.073 -9999.0 0.0 -0.286 1.0 1.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.037 -9999.0 0.0 -0.322 2.0 2.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.062 0.149 -9999.0 0.0 -0.467 10.0 10.0 STIL -0.023 0.115 -9999.0 0.0 -0.293 16.0 16.0 DHH N/PTCH2 0.016 0.042 -9999.0 0.0 -0.224 5.0 5.0 DHH N/PTCH1 -0.027 0.127 -9999.0 0.0 -0.358 12.0 12.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.01 0.03 -9999.0 0.0 -0.262 2.0 2.0 PTHLH -0.026 0.135 -9999.0 0.0 -0.459 7.0 7.0 determination of left/right symmetry -0.062 0.149 -9999.0 0.0 -0.467 10.0 10.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.026 0.134 -9999.0 0.0 -0.456 7.0 7.0 IHH N/Hhip -0.044 0.109 -9999.0 0.0 -0.238 38.0 38.0 DHH N/Hhip -0.029 0.096 -9999.0 0.0 -0.204 38.0 38.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.062 0.149 -9999.0 0.0 -0.467 10.0 10.0 pancreas development -0.054 0.133 -9999.0 0.0 -0.303 37.0 37.0 HHAT 0.003 0.073 -9999.0 0.0 -0.381 6.0 6.0 PI3K 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.041 0.127 -9999.0 0.0 -0.32 29.0 29.0 somite specification -0.062 0.149 -9999.0 0.0 -0.467 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.027 0.12 -9999.0 0.0 -0.313 16.0 16.0 SHH Np/Cholesterol/PTCH2 0.009 0.052 -9999.0 0.0 -0.189 9.0 9.0 SHH Np/Cholesterol/Megalin 0.001 0.056 -9999.0 0.0 -0.21 6.0 6.0 SHH 0.003 0.059 -9999.0 0.0 -0.217 11.0 11.0 catabolic process -0.037 0.14 -9999.0 0.0 -0.41 11.0 11.0 SMO/Vitamin D3 -0.045 0.13 -9999.0 0.0 -0.397 12.0 12.0 SHH Np/Cholesterol/Hhip -0.025 0.082 -9999.0 0.0 -0.204 20.0 20.0 LRP2 -0.003 0.064 -9999.0 0.0 -0.262 10.0 10.0 receptor-mediated endocytosis -0.037 0.133 -9999.0 0.0 -0.432 10.0 10.0 SHH Np/Cholesterol/BOC 0.01 0.048 -9999.0 0.0 -0.188 7.0 7.0 SHH Np/Cholesterol/CDO -0.01 0.073 -9999.0 0.0 -0.201 16.0 16.0 mesenchymal cell differentiation 0.025 0.082 0.203 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 -0.026 0.121 -9999.0 0.0 -0.313 16.0 16.0 IHH N/PTCH2 0.005 0.053 -9999.0 0.0 -0.241 5.0 5.0 CDON -0.026 0.108 -9999.0 0.0 -0.292 24.0 24.0 IHH N/PTCH1 -0.035 0.142 -9999.0 0.0 -0.412 11.0 11.0 Megalin/LRPAP1 0.011 0.044 -9999.0 0.0 -0.166 10.0 10.0 PTCH2 0.01 0.052 -9999.0 0.0 -0.381 3.0 3.0 SHH Np/Cholesterol 0.003 0.044 -9999.0 0.0 -0.194 6.0 6.0 PTCH1 -0.037 0.141 -9999.0 0.0 -0.411 11.0 11.0 HHIP -0.054 0.133 -9999.0 0.0 -0.304 37.0 37.0