E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.183 -9999.0 0.0 -0.427 31.0 31.0 KLHL20 -0.022 0.098 0.155 3.0 -0.209 24.0 27.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.337 2.0 2.0 Rac1/GDP -0.04 0.116 0.187 1.0 -0.241 32.0 33.0 ENAH -0.063 0.173 -9999.0 0.0 -0.401 31.0 31.0 AP1M1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.094 0.14 1.0 -0.19 28.0 29.0 ABI1/Sra1/Nap1 -0.038 0.06 -9999.0 0.0 -0.159 27.0 27.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.096 -9999.0 0.0 -0.177 28.0 28.0 RAPGEF1 -0.065 0.147 -9999.0 0.0 -0.344 31.0 31.0 CTNND1 0.024 0.049 -9999.0 0.0 -0.337 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.169 -9999.0 0.0 -0.387 31.0 31.0 CRK -0.064 0.156 -9999.0 0.0 -0.374 29.0 29.0 E-cadherin/gamma catenin/alpha catenin -0.014 0.123 -9999.0 0.0 -0.222 40.0 40.0 alphaE/beta7 Integrin 0.036 0.044 -9999.0 0.0 -0.228 4.0 4.0 IQGAP1 0.029 0.029 -9999.0 0.0 -0.337 1.0 1.0 NCKAP1 -0.001 0.099 -9999.0 0.0 -0.337 13.0 13.0 Rap1/GTP/I-afadin 0.044 0.055 -9999.0 0.0 -0.178 9.0 9.0 DLG1 -0.053 0.16 -9999.0 0.0 -0.386 29.0 29.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.063 -9999.0 0.0 -0.145 28.0 28.0 MLLT4 0.008 0.083 -9999.0 0.0 -0.337 9.0 9.0 ARF6/GTP/NME1/Tiam1 0.038 0.061 -9999.0 0.0 -0.178 11.0 11.0 PI3K -0.032 0.082 -9999.0 0.0 -0.184 28.0 28.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.028 0.131 -9999.0 0.0 -0.267 36.0 36.0 TIAM1 0.003 0.091 -9999.0 0.0 -0.337 11.0 11.0 E-cadherin(dimer)/Ca2+ 0.018 0.096 -9999.0 0.0 -0.175 31.0 31.0 AKT1 -0.026 0.049 -9999.0 0.0 -0.147 9.0 9.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.033 0.132 -9999.0 0.0 -0.337 26.0 26.0 RhoA/GDP -0.041 0.118 -9999.0 0.0 -0.242 32.0 32.0 actin cytoskeleton organization -0.013 0.076 0.139 5.0 -0.154 23.0 28.0 CDC42/GDP -0.042 0.119 0.269 1.0 -0.24 34.0 35.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.04 0.109 -9999.0 0.0 -0.213 43.0 43.0 ITGB7 0.023 0.057 -9999.0 0.0 -0.337 4.0 4.0 RAC1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.02 0.103 -9999.0 0.0 -0.187 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.01 0.085 -9999.0 0.0 -0.172 28.0 28.0 mol:GDP -0.06 0.125 -9999.0 0.0 -0.272 34.0 34.0 CDC42/GTP/IQGAP1 0.04 0.021 -9999.0 0.0 -0.195 1.0 1.0 JUP -0.008 0.111 -9999.0 0.0 -0.337 17.0 17.0 p120 catenin/RhoA/GDP -0.037 0.123 -9999.0 0.0 -0.247 33.0 33.0 RAC1/GTP/IQGAP1 0.036 0.022 -9999.0 0.0 -0.169 1.0 1.0 PIP5K1C/AP1M1 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.337 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.013 0.052 -9999.0 0.0 -0.127 17.0 17.0 NME1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.063 0.166 -9999.0 0.0 -0.389 31.0 31.0 regulation of cell-cell adhesion -0.024 0.079 -9999.0 0.0 -0.169 28.0 28.0 WASF2 -0.01 0.042 0.08 2.0 -0.089 24.0 26.0 Rap1/GTP -0.023 0.104 0.175 2.0 -0.209 28.0 30.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.01 0.123 -9999.0 0.0 -0.189 42.0 42.0 CCND1 -0.016 0.063 -9999.0 0.0 -0.155 17.0 17.0 VAV2 -0.092 0.218 -9999.0 0.0 -0.459 36.0 36.0 RAP1/GDP -0.028 0.11 0.193 1.0 -0.222 26.0 27.0 adherens junction assembly -0.062 0.161 -9999.0 0.0 -0.377 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.002 0.11 -9999.0 0.0 -0.186 40.0 40.0 E-cadherin/beta catenin -0.027 0.102 -9999.0 0.0 -0.274 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.07 0.167 -9999.0 0.0 -0.387 32.0 32.0 PIK3CA 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.063 0.131 -9999.0 0.0 -0.328 25.0 25.0 E-cadherin/beta catenin/alpha catenin 0.01 0.1 -9999.0 0.0 -0.205 28.0 28.0 ITGAE 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.053 0.172 -9999.0 0.0 -0.395 31.0 31.0