Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.041 0.125 -9999.0 0.0 -0.474 1.0 1.0 epithelial cell differentiation -0.079 0.135 -9999.0 0.0 -0.352 32.0 32.0 CYFIP2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.001 0.111 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.062 0.202 -9999.0 0.0 -0.584 28.0 28.0 EPHA2 -0.015 0.123 -9999.0 0.0 -0.525 12.0 12.0 MYO6 -0.043 0.144 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.155 0.198 -9999.0 0.0 -0.551 32.0 32.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.042 0.142 -9999.0 0.0 -0.325 32.0 32.0 regulation of calcium-dependent cell-cell adhesion -0.047 0.149 -9999.0 0.0 -0.335 34.0 34.0 EGF -0.042 0.179 -9999.0 0.0 -0.602 20.0 20.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.103 0.172 -9999.0 0.0 -0.596 15.0 15.0 cortical microtubule organization -0.079 0.135 -9999.0 0.0 -0.352 32.0 32.0 GO:0000145 -0.04 0.136 -9999.0 0.0 -0.311 32.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.08 0.136 -9999.0 0.0 -0.355 32.0 32.0 MLLT4 0.011 0.046 -9999.0 0.0 -0.673 1.0 1.0 ARF6/GDP -0.068 0.106 -9999.0 0.0 -0.473 1.0 1.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.016 0.064 -9999.0 0.0 -0.376 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.039 0.141 -9999.0 0.0 -0.43 1.0 1.0 PVRL2 0.011 0.046 -9999.0 0.0 -0.673 1.0 1.0 ZYX -0.046 0.145 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.014 0.057 -9999.0 0.0 -0.342 2.0 2.0 CDH1 -0.148 0.272 -9999.0 0.0 -0.592 59.0 59.0 EGFR/EGFR/EGF/EGF -0.129 0.184 -9999.0 0.0 -0.597 16.0 16.0 RhoA/GDP -0.073 0.125 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.035 0.139 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.019 0.141 -9999.0 0.0 -0.599 12.0 12.0 DIAPH1 0.004 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.079 0.135 0.352 32.0 -9999.0 0.0 32.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.069 0.107 -9999.0 0.0 -0.474 1.0 1.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.036 0.142 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.012 0.034 -9999.0 0.0 -0.495 1.0 1.0 LPP -0.051 0.15 -9999.0 0.0 -0.482 2.0 2.0 Ephrin A1/EPHA2 -0.083 0.127 -9999.0 0.0 -0.492 2.0 2.0 SEC6/SEC8 -0.065 0.115 -9999.0 0.0 -0.553 2.0 2.0 MGAT3 -0.048 0.152 -9999.0 0.0 -0.341 34.0 34.0 HGF/MET -0.187 0.197 -9999.0 0.0 -0.545 33.0 33.0 HGF -0.076 0.201 -9999.0 0.0 -0.519 37.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.042 0.126 -9999.0 0.0 -0.479 1.0 1.0 actin cable formation 0.015 0.109 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.08 0.196 -9999.0 0.0 -0.655 10.0 10.0 KIFC3 -0.045 0.15 -9999.0 0.0 -0.341 32.0 32.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.056 0.153 -9999.0 0.0 -0.455 3.0 3.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.079 0.135 -9999.0 0.0 -0.352 32.0 32.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.043 0.144 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.043 0.144 -9999.0 0.0 -0.33 32.0 32.0 LIMA1 -0.008 0.121 -9999.0 0.0 -0.673 7.0 7.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.06 0.093 -9999.0 0.0 -0.407 1.0 1.0 adherens junction assembly -0.057 0.19 -9999.0 0.0 -0.607 10.0 10.0 IGF-1R heterotetramer/IGF1 -0.085 0.141 -9999.0 0.0 -0.632 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.005 0.047 -9999.0 0.0 -0.497 2.0 2.0 MET -0.164 0.273 -9999.0 0.0 -0.569 67.0 67.0 PLEKHA7 -0.052 0.155 -9999.0 0.0 -0.531 3.0 3.0 mol:GTP -0.016 0.063 -9999.0 0.0 -0.374 2.0 2.0 establishment of epithelial cell apical/basal polarity -0.01 0.137 -9999.0 0.0 -0.522 2.0 2.0 cortical actin cytoskeleton stabilization -0.041 0.125 -9999.0 0.0 -0.474 1.0 1.0 regulation of cell-cell adhesion -0.035 0.139 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.042 0.126 -9999.0 0.0 -0.479 1.0 1.0